Pazopanib Hydrochloride CAS 635702-64-6 Purity >99.0% (HPLC) API Factory

Whakaahuatanga Poto:

Ingoa matū: Pazopanib Hydrochloride

CAS: 635702-64-6

Te ahua: Paura Ma ki te Paura Paariki

Maamaa: >99.0% (HPLC)

Tirosine kinase receptor inhibitor mo te maimoatanga mate pukupuku pūtau whatumanawa matatau ranei sarcoma kiko ngohengohe matatau

API Kounga Teitei, Hanganga Tauhokohoko

Inquiry: alvin@ruifuchem.com

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Whakaahuatanga:

Ko te Kaihanga Kaihanga me te Maama me te Kounga Pumau
Ingoa matū: Pazopanib Hydrochloride
CAS: 635702-64-6
Ko te aukati kaiawhina Tyrosine kinase mo te maimoatanga o te mate pukupuku renal cell, sarcoma kiko ngohengohe ranei kua whiwhi i te chemotherapy o mua.
API Kounga Teitei, Hanganga Tauhokohoko

Ngā Āhuatanga matū:

Ingoa matū	Pazopanib Hydrochloride
Nga kupu taurite	Pazopanib HCl;GW786034 HCl;Pooti;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride
Tau CAS	635702-64-6
Tau CAT	RF-API93
Tūnga Taonga	Kei roto i nga taonga, ka eke ki te rau kirokaramu
Tātai rāpoi	C21H23N7O2S.ClH
Taumaha rāpoi	473.987
Wairewa	DMSO
Iwi Whakarewa	300.0~304.0 ℃
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Paura ma ki te paku kowhai
Tautuhinga	Ko te awheawhe whakauru o te tauira whakamatautau he rite ki tera o te paerewa
Te toenga i runga i te mura	≤0.50%
Te poke takitahi	≤0.30%
Nga poke katoa	≤1.50%
Nga Korewa Taamaha	≤10ppm
Te Maama / Tikanga Tatauria	≥99.0% (HPLC)
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	API, Tyrosine kinase kaiawhina kaiwhakawhiwhi

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.

Painga:

FAQ:

Taupānga:

Ko te Pazopanib Hydrochloride (CAS 635702-64-6) he aukati tini-tyrosine kinase o te vascular endothelial growth factor receptor (VEGFR) -1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR) -α me - β, fibroblast growth factor receptor (FGFR)-1 me -3, cytokine receptor (Kit), interleukin-2 receptor-inducible T-cell kinase (Itk), lymphocyte-specific protein tyrosine kinase (Lck), me te transmembrane glycoprotein receptor tyrosine kinase (cFms).In vitro, pazopanib inhibited ligand-induced autophosphorylation of VEGFR-2, Kit, and PDGFR-beta receptors.In vivo, pazopanib inhibited VEGF-induced VEGFR-2 phosphorylation i roto i nga ngongo kiore, angiogenesis i roto i te tauira kiore, me te tipu o etahi xenografts puku tangata i roto i nga kiore.I whakamanahia mo te mate pukupuku renal cell e te US Food and Drug Administration i te tau 2009 ka hokona i raro i te ingoa hokohoko Votrient e te kaihanga o te tarukino, a GlaxoSmithKline.Ko te Votrient he aukati kinase e tohuhia ana mo te maimoatanga o nga turoro me: 1) te mate pukupuku o te renal cell.2) sarcoma kiko ngohe matatau kua whiwhi i te chemotherapy o mua.