Posaconazole CAS 171228-49-2 API Factory Triazole Antifungal Agent Kounga Teitei
Nga Taonga Wheketere Posaconazole Related Intermediates, Acommercial Production
Posaconazole CAS 171228-49-2
Posaconazole Intermediate POA CAS 149809-43-8
Phenyl (4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)carbamate CAS 184177-81-9
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine CAS 74853-08-0
2-[(1S,2S)-1-Ethyl-2-(phenylmethoxy)propyl]hydrazinecarboxal CAS 170985-85-0
Diethyl L-(+)-Tartrate CAS 87-91-2
Ingoa matū | Posaconazole |
Nga kupu taurite | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl] methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one |
Tau CAS | 171228-49-2 |
Tau CAT | RF-API77 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C37H42F2N8O4 |
Taumaha rāpoi | 700.78 |
Kiato | 1.36 g/cm3 |
Wairewa | Wairewa i roto i DMSO, Insoluble i roto i te wai |
Tikanga Tukunga | Ka tukuna i raro i te pāmahana ambient |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura Tioata-White |
Tautuhi A | IR: Ko te tuāwhiorangi whakauru infrared o te hua kia rite ki tera o te matū tohutoro |
Tautuhinga B | He rite te wa pupuri HPLC ki te matū tohutoro |
Iwi Whakarewa | 167.0~171.0℃ |
Hurihuri Tau [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Wai (KF) | ≤1.0% |
Te toenga i runga i te mura | ≤0.10% |
Nga Taonga Paanga | |
HT 909-24 | ≤0.20% |
Te poke takitahi | ≤0.10% |
Nga poke katoa | ≤1.0% |
Wairewa toenga | |
Mewaro | ≤3000ppm |
Methyl tert-Butyl Ether | ≤5000ppm |
Isopropanol | ≤5000ppm |
Dimethyl Sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Te whakamatautau | 98.0%~102.0% (Kua tatauhia i runga i te whakamaroke) |
Nga Korewa Taamaha | ≤10ppm |
Isomer | Enantiomer ≤0.10% |
Tetahi poke takitahi ≤0.10% | |
Tapeke Parakore ≤1.0% | |
Paerewa Whakamatau | Paerewa hinonga;USP;BP;EP Paerewa |
Whakamahinga | API, Triazole Antifungal Agent |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Posaconazole (CAS 171228-49-2), he whaanui whanui, reanga tuarua, triazole pūhui me te mahi antifungal, i whakarewahia i te UK, ko te mema hou o te akomanga azole o nga kaihoko antifungal kia tae ki te maakete.E tohuhia ana mo te maimoatanga me te aukati i te tini o nga mate harore invasive, tae atu ki te aspergillosis, fusariosis, chromoblastomycosis, mycetoma, me te coccidiomycosis i roto i nga turoro e whakakeke ana, e kore e aro ki te rongoa paerewa me te amphotericin B me/ranei itraconazole.I roto i te US, ka whakaaetia mo te aukati i nga mate urutomo Aspergillus me Candida ki nga turoro 13 tau te pakeke e tino tupono ana ki te whakawhanake i enei mate na te kaha o te mate mate.I tua atu, kua whakaaetia mo te maimoatanga o te candidiasis oropharyngeal.Ko te Posaconazole he nui ake te mahi a te Posaconazole ki runga ake i etahi atu mema o te azole antifungals.I tua atu i te kaha kaha ki te aukati i nga keehi o te aspergillosis me te Candida-atete ki te fluconazole, e whakaatu ana i te mahi ki a Zygomycetes.Ko te Posaconazole he tarukino antifungal triazole i hokona i te United States e Schering-Plough i raro i te ingoa hokohoko Noxafil.