(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst CAS 112022-83-0 Maamaa Optical ≥98.0%

Kaihanga Kaihanga;Kounga teitei me te utu whakataetae

CBS Catalysts
(S)-(-)-2-Methyl-CBS-oxazaborolidine;(S)-Me-CBS Catalyst (ca. 1mol/L i Toluene);CAS: 112022-81-8
(R)-(+)-2-Methyl-CBS-oxazaborolidine;(R)-Me-CBS Catalyst (ca. 1mol/L i Toluene);CAS: 112022-83-0

CBS Catalyst
Ko te CBS catalyst, Corey–Bakshi–Shibata catalyst ranei he whakakōkī hangarite i ahu mai i te proline.He maha nga whakamahinga i roto i nga tauhohenga waro penei i te whakahekenga CBS, nga tauhohenga Diels-Alder me te (3+2) cycloadditions.Ko te Proline, he puhui chiral taiao, he ngawari me te utu iti.Ka whakawhitia e ia tana pokapū stereo ki te whakakorikori ka taea e ia te peia he tauhohenga waro ki tetahi o nga enantiomers e rua.Ko tenei whiriwhiringa na te riaka uwha i roto i te ahua whakawhiti ka whanake mo tetahi enantiomer engari kaua mo tetahi atu.

CBS Catalysts mo te Whakaiti Asymmetric me te Synthesis Asymmetric
Kua whakamahia te CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst i roto i te whakahekenga hangarite o nga ketones prochiral.Ko etahi atu tono ko te whakahiato enantioselective o nga waikawa α-hydroxy, waikawa α-amino, C2-symmetrical ferrocenyl diols, me nga waipiro propargyl.

(R)-(+)-2-Methyl-CBS-oxazaborolidine (ca. 1mol/L i roto i te Toluene) CAS: 112022-83-0 ka taea te whakamahi hei whakakorikori i roto i te whakaiti borane asymmetric o perfluoroalkyl ketones.Ko etahi atu tono ko te whakahiato enantioselective o nga waikawa α-hydroxy, waikawa α-amino, C2 symmetrical ferrocenyl diols, me nga waipiro propargyl.Ka whakamahia ano hoki i roto i te whakahekenga desymmetrizing e arahi ana ki te (S) -4-hydroxycyclohexenone.He pai ki te hanga i nga kaupapa stereospecific penei i te waikawa α-hydroxy, waikawa α-amino, diols ferrocenyl hangarite me te waipiro propargyl.

(R)-(+)-2-Methyl-CBS-oxazaborolidine (ca. 1mol/L i Toluene) CAS: 112022-83-0 he whakakōkī organoboron e whakamahia ana i roto i te whakahiato waro.Ko tenei whakakorikori, i hangaia e Itsuno me Elias James Corey, ka hangaia e te whakamahana (R)-(+)-2-(diphenylhydroxymethyl) pyrrolidine me te trimethylboroxine me te waikawa methylboronic ranei.He taputapu pai mo te whakahiato waipiro i roto i te ōwehenga enantiomeric teitei.Ko te tikanga, ka whakamahia te 2-10 mol% o tenei whakakorikori me te borane-tetrahydrofuran (THF), borane-dimethylsulfide, borane-N,N-diethylaniline, diborane ranei hei puna borane.Ko te whakahekenga Enantioselective ma te whakamahi i te chiral oxazaborolidine catalysts kua whakamahia i roto i te whakahiatotanga o nga raau taero arumoni penei i te ezetimibe me te aprepitant.