(R)-(-)-3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem and Darifenacin hydrobromide Intermediate
Kaihanga Kaihanga;Te Pure Nui me te Utu Whakataetae
Shanghai Ruifu Chemical Co., Ltd. Tauranga Aromoni Chiral Compounds:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S)-3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Takawaenga o Panipenem (CAS 87726-17-8) me Darifenacin hydrobromide (CAS 133099-07-7)
| Ingoa matū | (R)-(-)-3-Pyrrolidinol Hydrochloride |
| Nga kupu taurite | (R)-(-)-3-Hydroxypyrrolidine Hydrochloride;(R)-(-)-3-Hydroxypyrrolidine-HCl |
| Tau CAS | 104706-47-0 |
| Tau CAT | RF-CC102 |
| Te Maama / Tikanga Tatauria | ≥98.0% (GC) |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C4H10ClNO |
| Taumaha rāpoi | 123.58 |
| Iwi Whakarewa | 107.0 ~ 111.0 °C |
| Wairewa i te wai | Tata Puataata |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura-White ki te Paura Paraone Tioatarangi Paura |
| Te Maama / Tikanga Tatauria | ≥99.7% (GC) |
| Chiral Pure | ≥99.7% ee |
| Te toenga i runga i te mura | ≤0.50% |
| Hurihuri Tauwhāiti [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Te poke takitahi | ≤0.20% |
| Ko nga poke katoa | ≤0.30% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga Rongoa;Pūhui Hira |
Tikanga Tātari
Taputapu: GC taputapu (Shimadzu GC-2010)
Tīwae: DB-17 Agilent 30mX0.53mmX1.0μm
Te pāmahana oumu tuatahi: 80 ℃
Wā tuatahi 2.0min
Reiti 15℃/min
Te pāmahana oumu whakamutunga: 250 ℃
Te wa whakamutunga 20min
hau kawe hau hauota
Aratau Rere tonu
Rere 5.0mL/min
Ritua ōwehenga 10:1
Te pāmahana injector: 250 ℃
Te pāmahana kaitirotiro: 300 ℃
rōrahi werohanga 1.0μL
Ko nga mahi whakatupato i mua i te tātaritanga:
1. Whakaritea te pou i te 240 ℃ mo te 30 meneti iti rawa.
2. Horoi tika i te syringe me te injector liner ki te tango i nga poke o te tātaritanga o mua.
3. Horoi, whakamaroke ka whakakiia te waimeha ki roto i nga ipu horoi syringe.
Whakaritenga waimeha:
Whakaritea 2% w/v wairewa konutai waihā ki te wai.
Whakaritenga Paerewa:
Paunatia te 100mg o te paerewa (R)-3-hydroxyprrolidine hydrochloride ki roto i te ipu, taapirihia te 1mL o te waimeha ka rewa.
Whakaritenga whakamatautau:
Paunatia te 100mg o te tauira whakamatautau ki roto i te ipu, taapirihia te 1mL o te waimeha ka rewa.Whakaritea kia takirua.
Tikanga:
Werohia kia patea (whakawa), whakarite paerewa me te whakarite whakamatautau ma te whakamahi i nga tikanga o runga ake o te GC.Kaua e aro ki nga tihi na te mea kua patea.Ko te wa pupuri o te tihi na te (R) -3-hydroxyprrolidine e tata ana ki te 5.0min.
Tuhipoka:
Pūrongohia te hua hei toharite
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o (R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) me te kounga teitei, e whakamahia nuitia ana i roto i te whakahiato waro, te whakahiato o nga takawaenga rongoa. me te whakahiatotanga Active Pharmaceutical Ingredient (API).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) he takawaenga i te nuinga o te wa i te whakahiato o Panipenem (CAS 87726-17-8) me Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-)-3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) ko te chiral hydroxy derivative o pyrrlodine whakamahia i roto i te faaineineraa o chiral niologically pūhui kaha pērā i antagonists receptor muscarinic me āpiha antimicrobial.
Te huarahi o te whakahiatotanga o (R)-3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile i tauhohehia ki te trimethyl chlorosilane i roto i te whakarewa dichloromethane ki te whiwhi (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine i muri mai i te hydrogenated i runga i te Pd/C catalyst. (R) -3-trimethylsiloxyepyrrolidine i whiwhihia e te konutai hydroxide mowhiti kati maimoatanga.I te mutunga, ko te hua (R) -3-hydroxypyrrolidine hydrochloride i whiwhihia e te maimoatanga waikawa waikawa konutai ka tangohia te roopu whakamarumaru trimethylsilyl.
