Ramelteon (TAK-375) CAS 196597-26-9 Purity >99.5% (HPLC)
Kaihanga Kaihanga me te Kaiwhakarato, Kaiwaenga o Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-one CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
Ingoa matū | Ramelteon |
Nga kupu taurite | (S)-N-[2-(2,6,7,8-Tetrahydro-1H-Indeno[5,4-b]furan-8-yl)ethyl]propionamide;TAK-375;TAK375;TAK 375;Rozerem |
Tau CAS | 196597-26-9 |
Tau CAT | RF2885 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C16H21NO2 |
Taumaha rāpoi | 259.35 |
Iwi Whakarewa | 113.0 ki te 116.0 ℃ |
Kohuatanga | 455.3±24.0℃ |
Kiato | 1.119±0.06 g/cm3 |
Hurihuri Tau [α]20/D | -55.0° ki te -60.0° (C=1, CHCL3) |
Wairewa i te wai | Kore ki te wai (11 mg/l 25 ℃) |
Wairewa | Wairewa i te Ewaro, Mewaro, DMSO |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Paura Tioata Ma |
Te Maama / Tikanga Tatauria | >99.5% (HPLC) |
Iwi Whakarewa | 113.0~116.0℃ |
Ngaronga i te whakamaroke | <0.50% |
Te toenga i runga i te mura | <0.10% |
Isomer Pure | <0.10% |
Nga Korewa Taamaha | <10ppm |
Waiwawawa ranei | Whakaritea |
Ewaro | <5000ppm |
Te poke kotahi | <0.20% |
Nga poke katoa | <0.50% |
Spectrum Infrared | He rite ki te Hanganga |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | API, Kua whakaaetia mo te maimoatanga o te ohoroa |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
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Ko Ramelteon (CAS: 196597-26-9) i whakaaetia tuatahi e te US Food and Drug Administration (FDA) i te Hurae 22, 2005, katahi ka whakaaetia e te Pharmaceuticals and Medical Devices Agency (PMDA) i te Apr 16, 2010. I whakawhanakehia, i hokohoko hei Rozerem® na Takeda,Ka taea te whakamahi ki te rongoa i te ohoroa me te uaua ki te moe, me te tino paanga ki te ohoroa roa me te ohoroa mo te wa poto.Ka taea e tenei hua te whakahohe i te momo 1 me te momo 2 nga kaiwhakawhiwhi o te melatonin (MT1, MT2), te whakanui ake i te moe ngaru puhoi (SWS) me te tere o te moe nekehanga kanohi (REW), na reira ka whakaiti i te ohoroa.Ko Ramelteamide te rongoa rongoa ohoroa tuatahi kaore i raro i te mana motuhake.Ko tenei hua he agonist whakawhiwhi melatonin.He tino hononga ki te melatonin MT1 me te MT2 nga kaiwhakawhiwhi, a he tino whai mana agonistic me te whakaoti i runga i nga kaiwhakawhiwhi MT1 me MT2, engari kaore i te taunekeneke ki te kaiwhakawhiwhi MT3.I tua atu, kaore e herea ana ki nga kaiwhakawhiwhi neurotransmitter penei i nga matatini kaikawe GABA, kaore hoki e pokanoa ki te mahi o te nuinga o nga enzymes i roto i tetahi waahanga.Na reira, ka taea e ia te karo i te whakararuraru e pa ana ki nga raau taero GABA (e aituā motika, ka hinga me te whati).Etc.) me te taapiri tarukino me te whakawhirinaki.Kei te waatea a Rozerem® hei papa pani-kiriata mo te whakamahi waha, kei roto te 8 mg o Ramelteon kore utu.Ko te horopeta pakeke e taunakitia ana ko te 8 mg ka tangohia i roto i te 30 meneti ka moe.