Rivastigmine Tartrate CAS 129101-54-8 Assay 98.0~102.0
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o Rivastigmine Tartrate (CAS: 129101-54-8) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Rivastigmine Tartrate,Please contact: alvin@ruifuchem.com
| Ingoa matū | Rivastigmine Tartrate |
| Nga kupu taurite | Exelon;ENA-713;Rivastigmine L-Tartrate;Rivastigmine Hydrogen Tartrate;CS-118;S-Rivastigmine Tartrate;3-[(S)-1-(Dimethylamino)ethyl]phenyl N-Ethyl-N-Methylcarbamate L-Tartrate;N-Ethyl-N-Methylcarbamic Acid 3-[(S)-1-(Dimethylamino)ethyl]phenyl Ester L-Tartrate |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 129101-54-8 |
| CAS e pa ana | 123441-03-2 |
| Tātai rāpoi | C14H22N2O2·C4H6O6 |
| Taumaha rāpoi | 400.43 g/mol |
| Iwi Whakarewa | 124.0 ki te 128.0 ℃ |
| Hurihuri Tau [a]20/D | +4.0° ki te +7.0° (C=5, Methanol) |
| Wairewa | Wairewa ki Methanol |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Ma ki te Paura Tioata-White | Ka tutuki |
| Te whakamatautau | 98.0~102.0% (i runga i te Turanga Anhydrous) | 99.8% |
| Wai na Karl Fischer | ≤0.50% | 0.15% |
| Te toenga i runga i te mura | ≤0.10% | 0.07% |
| Konga Taamaha (Pb) | ≤20ppm | <10ppm |
| Phenol poke | ≤0.30% | <0.30% |
| DPTTA | ≤0.15% | <0.15% |
| Ko te poke ranei | ≤0.15% | <0.15% |
| Carbamate poke | ≤0.15% | <0.15% |
| Etere poke | ≤0.15% | <0.15% |
| Tetahi atu poke | ≤0.10% | <0.10% |
| Ko nga poke katoa | ≤0.50% | <0.50% |
| R-Enantiomer | ≤0.30% | <0.30% |
| Spectrum Infrared | E rite ana ki te Hanganga | Ka tutuki |
| 1H NMR Spectrum | E rite ana ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki te Paerewa USP35 | |
Mōkī:Pounamu Fluorinated, Peeke pepa konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Rivastigmine Tartrate
C14H22N2O2·C4H6O6 400.42
Te waikawa Ethylmethylcarbamic, 3- [(S) -1-(dimethylamino)ethyl] phenyl ester, (2R,3R) -2,3-dihydroxybutanedioate;
(S)-3-[1-(Dimethylamino)ethyl]phenyl ethylmethylcarbamate, hydrogen tartrate [129101-54-8].
Rivastigmine 250.34 [123441-03-2].
WHAKAMAHI
Rivastigmine Tartrate kei roto NLT 98.0% me NMT 102.0% o te nui tapanga o C14H22N2O2·C4H6O6, tatau i runga i te tikanga anhydrous.
WHAKATAUTANGA
• A. Te Kohanga Pokarekare <197K>
• B. Ko te wa pupuri o te tihi nui o te otinga Tauira e rite ana ki tera o te otinga pai o te Pūnaha, i whiwhihia i roto i te whakamatautau mo nga Parapara Organic, Tikanga 2: Enantiomeric Purity.
WHAKAMAHI
• Tikanga
Kaipupuri: 8.6 mg/mL o te haukinia phosphate monobasic.Whakaritea me te wairewa haukini ki te pH 7.0.
Wāhanga pūkoro: Methanol, acetonitrile, me te Buffer (15:15:70)
Te otinga pai o te punaha: 0.05 mg/mL ia USP Rivastigmine Pānga Pūhui A RS me USP Rivastigmine Pānga Pūhui B RS i te wahanga Pūkoro
Te otinga paerewa: 0.2 mg/mL o te USP Rivastigmine Tartrate RS i te wahanga Waea
Tauira otinga: 0.2 mg/mL o Rivastigmine Tartrate i roto i te wahanga Mobile
Pūnaha Chromatographic
(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC
Kaitirotiro: UV 215 nm
Tīwae: 4.6-mm × 25-cm;5-µm kiki L7
Rere rere: 1.2 mL/min
Rahi werohanga: 20 µL
[Tuhipoka-Ka taea te whakarereke i te tere o te rere ki te 1.5 mL/min, ki te hiahiatia, ki te whakatutuki i te wa pupuri i te rivastigmine i te 10 meneti pea.]
Te pai o te punaha
Tauira: Te otinga pai o te punaha me te otinga Paerewa
Nga whakaritenga e tika ana
Whakatau: NLT 1.5 i waenga i te rivastigmine e pa ana ki te puhui A me te rivastigmine e pa ana ki te B, te otinga pai o te punaha
Te pai o te pou: NLT 5000 nga papaa whakaaro, otinga Paerewa
Tauwehe hiku: NMT 3.0, otinga Paerewa
Te inenga paerewa whaitake: NMT 2.0%, otinga Paerewa
Tātaritanga
Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o C14H22N2O2·C4H6O6 i te wāhanga o Rivastigmine Tartrate i tangohia:
Hua = (rU/rS) × (CS/CU) × 100
rU = te whakautu teitei mai i te Tauira otinga
rS = te whakautu teitei mai i te otinga Paerewa
CS = te kukū o te otinga Paerewa (mg/mL)
CU = te kukū o te otinga Tauira (mg/mL)
Paearu whakaae: 98.0% -102.0% i runga i te kaupapa anhydrous
NGA POKE
Nga poke parakore
• Te toenga i runga i te mura <281>: NMT 0.1%
• Nga Koura Nui, Tikanga II <231>: NMT 20 ppm
Nga poke pararopi
• Tikanga 1
Wāhanga pūkoro me te otinga pai o te Pūnaha: Haere tonu i roto i te Whakatau.
Wairewa Paerewa: 1.0 µg/mL o USP Rivastigmine Tartrate RS i te wahanga Waea pūkoro
Tauira otinga: 1.0 mg/mL o Rivastigmine Tartrate i roto i te wahanga Mobile
Pūnaha Chromatographic: Haere i runga i te tohutohu i roto i te Whakamaatau.
(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Te pai o te punaha
Tauira: Te otinga pai o te punaha me te otinga Paerewa
Nga whakaritenga e tika ana
Whakatau: NLT 1.5 i waenga i te rivastigmine e pa ana ki te puhui A me te rivastigmine e pa ana ki te B, te otinga pai o te punaha
Te inenga paerewa whaitake: NMT 10%, otinga Paerewa
Tātaritanga [Tuhipoka-Ko te wa oma he 8 wa te wa pupuri o te tihi rivastigmine.]
Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o te poke takitahi i te wahanga o Rivastigmine Tartrate i tangohia:
Hua = (rU/rS) × (CS/CU) × (1/F) × 100
rU = te whakautu teitei mo ia poke mai i te otinga Tauira
rS = te whakautu teitei mai i te otinga Paerewa
CS = te kukū o te USP Rivastigmine Tartrate RS i te otinga Paerewa (mg/mL)
CU = te kukū o te Rivastigmine Tartrate i roto i te otinga Tauira (mg/mL)
F = tauwehe whakautu whanaunga (tirohia te Ripanga poke 1)
Paearu whakaae
Nga poke takitahi: Tirohia te Ripanga poke 1.
Tapeke poke: NMT 0.5%
Ripanga poke 1
| Ingoa | Wā Pupuri Whanaunga | Tauwehe Whakautu Paanga | Paearu Whakaae NMT % |
| Tarrate | 0.18 | — | Kore whakaaro |
| Phenol poke | 0.28 | 1.6 | 0.3 |
| DPTTAb | 0.46 | 0.83 | 0.15 |
| Kaua hoki te pokec | 0.57 | 1.2 | 0.15 |
| Rivastigmine | 1.0 | 1.0 | — |
| Carbamate poke | 4.1 | 1.3 | 0.15 |
| Etere poke | 6.5 | 1.4 | 0.15 |
| Tetahi atu poke | — | 1.0 | 0.1 |
a (S)-3-[1-(Dimethylamino)ethyl]phenol.
b (+)-Di-(p-toluoyl)-d-tartaric acid (rivastigmine related compound A).
c (S)-3-[1-(Dimethylamino)ethyl]phenyl dimethylcarbamate (rivastigmine related compound B).
d 3-Nitrophenyl ethyl(methyl)carbamate.
e (S)-N,N-Dimethyl-1-[3-(4-nitrophenoxy)phenyl]ethanamine.
• Tikanga 2: Enantiomeric Purity
Kaipupuri: Whakawhitihia te 1.78 g o te konutai konutai phosphate dihydrate me te 1.38 g o te konutai konutai phosphate ki roto i te ipu 1000-mL.Whakarewa ki roto ka waimeha ki te wai ki te rōrahi.Whakaritea me te waikawa phosphoric ki te pH 6.0.
Wāhanga pūkoro: Whakawhitihia te 20 mL o te acetonitrile me te 205 µL o te N,N-dimethyloctylamine ki te ipu rōrahi 1000-mL, ka waimeha ki te Buffer ki te rōrahi.
Wairewa Paerewa: 0.1 µg/mL o USP Rivastigmine Tartrate R-Isomer RS i te wahanga Waea
Te otinga tairongo: 0.05 µg/mL o USP Rivastigmine Tartrate R-Isomer RS i te wahanga Waea Waea, Wairewa Paerewa
Te otinga pai o te punaha: 100 µg/mL o USP Rivastigmine Tartrate RS me te 0.1 µg/mL o USP Rivastigmine Tartrate R-Isomer RS i te wahanga Waea
Tauira otinga: 100 µg/mL o Rivastigmine Tartrate i roto i te wahanga Waea Pukoro
Pūnaha Chromatographic
(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC
Kaitirotiro: UV 200 nm
Tīwae: 4.0-mm × 10-cm;whakakai L41
Rere rere: 0.5 mL/min
Rahi werohanga: 20 µL
Te pai o te punaha
Tauira: Te otinga Paerewa, te otinga Taarongo, me te otinga pai o te punaha
Nga whakaritenga e tika ana
Whakataunga: NLT 0.8 i waenga i nga tihi enantiomer, otinga pai o te punaha
[Tuhipoka-Ko te raupapa elution ko te R-enantiomer, whai muri ko te tihi rivastigmine, ko te S-enantiomer.]
Te ōwehenga tohu-ki-haruru: NLT 10, Te otinga tairongo
Te inenga paerewa whaitake: NMT 10%, otinga Paerewa
Tātaritanga
Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o te R-enantiomer i te wahanga o Rivastigmine Tartrate i tangohia:
Hua = (rU/rS) × (CS/CU) × 100
rU = te whakautu teitei o te R-enantiomer mai i te otinga Tauira
rS = te whakautu teitei o te R-enantiomer mai i te otinga Paerewa
CS = te kukū o te R-enantiomer i te otinga Paerewa (µg/mL)
CU = te kukū o te Rivastigmine Tartrate i te Tauira otinga (µg/mL)
Paearu whakaae: NMT 0.3% o te R-enantiomer
NGA WHAKAMATAUTANGA
• Te Whakatau Wai, Tikanga Ia <921>: NMT 0.5%
HE WHAKAMAHI ATU
• Whakapaipai me te Rokiroki: Whakaorangia ki roto i nga ipu kiki, ka rongoa ki te pāmahana rūma.
• Paerewa Tohutoro USP <11>
USP Rivastigmine Tartrate RS
USP Rivastigmine Related Compound A RS
Di-p-toluoyl-d-(+)-tartaric acid monohydrate.
C20H20O9 404.37
USP Rivastigmine Related Compound B RS
N,N-Dimethylcarbamic acid-3-[1-(dimethylamino)ethyl]phenyl ester.
C13H20N2O2 236.32
USP Rivastigmine Tartrate R-Isomer RS
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Roopu Tapaki III
Ko te Rivastigmine Tartrate (CAS: 129101-54-8) te tartrate o te rivastigmine, he rongoa mo te maimoatanga o te mate a Alzheimer.Ko te Rivastigmine he whakaputanga physostigmine, i angitu te whakawhanake mo te wa tuatahi e Novartis, Switzerland.Ko te ingoa hokohoko ko te exelon, a he hanganga benzyl carbamate te ngota, he karakate roro-whiriwhiri cholinesterase inhibitor, ka taea te whakakore i te acetylcholinesterase me te butyrylcholinesterase i te wa ano, me te whakatairanga i te whakawhitinga nerve cholinergic ma te whakaroa i te paheketanga o te acetylcholine i tukuna e te cholinergic neurons.Ka taea e ia te whakapai ake i te ngoikoretanga o te hinengaro i takawaenga e te cholinergic, na reira ka pai ake te painga o te hinengaro o nga turoro me te mate a Alzheimer.Ko te kaha o te herenga pūmua plasma o te rivastigmine he ngoikore, he ngawari ki te haere i roto i te arai toto-roro, me te tohu nui o te whiriwhiringa o te roro.Kaore e taea te mahi maataki noa i nga waahi whakaraerae o te uho roro me te hippocampus, engari he pai ki te aukati i nga momo iti o te AChE i roto i te roro, ka taea te whakaiti i nga paanga taha cholinergic peripheral i te wa e whakaputa ana i nga hua whakaora.He poto te haurua o te rivastigmine tartrate i roto i te tinana, he roa te wa mahi.Kaore i rite ki te tacrine, he kaha ake te aukati o tenei hua ki te G1 enzyme i roto i te hippocampus me te uho.Ka whakamahia e te haumanu ki te rongoa i te mate ngoikore o Alzheimer, e whakapaetia ana he mate a Alzheimer, he mate Alzheimer ranei.
1. Hei aukati acetylcholinesterase, ka taea e te rivastigmine bicartrate te whakapai ake i te painga o te whakangao uaua succinylcholine.No reira, me whai waahi pai mo te whakamutu i te tango i tenei hua i mua i te rewharewha.Me honoa tenei hua ki etahi atu whakaritenga cholinergic, anticholinergic ranei, me te tupato (tirohia te [Whakawhitinga Taonga]).
2. Na te kaha o te rongoa, ka pa mai pea nga aukati o te cholinesterase ki te raru o te uaua ki te reiti o te ngakau.Pērā ki ētahi atu raau taero cholinergic, me tūpato i te wa e tukuna ana ki nga turoro e mate ana i te mate sinus syndrome, i etahi atu paraka ngakau ranei (tirohia nga Tauhohenga Kino).
3. Ko te hihikotanga o te nerve cholinergic ka nui ake te whakaputanga waikawa pekitīlia.Ahakoa karekau he taunakitanga o te tino paheketanga o nga tohu e rite ana i kitea i te wa o te whakamatautau haumanu, ko nga turoro he nui te mate o te mate whewhe puku, penei i te hunga he hitori o te mate whewhe, ko te hunga ranei e whiwhi ana i te maimoatanga whakakotahi me nga raau taero anti-inflammatory kore-steroidal, me whakamahi tupato.
4. Pērā i ētehi atu aukati cholinesterase, me tūpato ngā tūroro e pā ana ki te mate huangō me ētahi atu mate pūkahukahu aukati.
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