Roflumilast CAS 162401-32-3 Tirohanga 99.0~101.0% API
Ruifu Chemical Supply Roflumilast Intermediates:
Roflumilast CAS 162401-32-3
4-Amino-3,5-Dichloropyridine CAS 22889-78-7
Ingoa matū | Roflumilast |
Nga kupu taurite | 3-(Cyclopropylmethoxy)-N-(3,5-Dichloropyridin-4-yl)-4-(Ddifluoromethoxy)benzamide |
Tau CAS | 162401-32-3 |
Tau CAT | RF-PI2075 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C17H14Cl2F2N2O3 |
Taumaha rāpoi | 403.21 |
Kiato | 1.471±0.060 g/cm3 |
Te tairongo | Te werawera |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Paura ma, tata ma ranei te kirikiriata |
Wairewa | He memeha noa i roto i te acetone, he iti te memeha ki te acetronitrile, he iti te memeha ki te waiwaro waiwaro, kare e memeha ki te wai |
Iwi Whakarewa | 157.0~162.0℃ |
Ngaronga i te whakamaroke | <0.50% |
Te toenga i runga i te mura | ≤0.10% |
Nga Korewa Taamaha | ≤10ppm |
pūhaumāota | ≤0.01% |
Tautuhi A. UV | Ko te roangaru o te whakaurunga teitei kia 213~251nm |
Tautuhinga B. IR | Ko te hihinga whakauru IR o te tauira e rite ana ki tera o te tohutoro |
Tautuhinga C. | Ka whakaatu i te tauhohenga o te Fluoride |
Nga Taonga Paanga | |
Te poke kotahi | ≤0.10% |
Nga poke katoa | <0.50% |
Wairewa toenga | |
Tert-Butanol | <0.10% |
Tetrahydrofuran | <0.072% |
Toluene | <0.089% |
N,N-Dimethylformamide | <0.088% |
Te whakamatautau | 99.0~101.0% (Kua Tatauhia i runga i te Tikanga maroke) |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | API;COPD |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku
Ko te Roflumilast (CAS: 162401-32-3) he aukati phosphodiesterase-4 (PDE-4) a-waha whiriwhiri me te puhui benzamide.I whakawhanakehia e te kamupene Tiamana Altana i te tau 1993, ko ia anake te aukati PDE-4-waha i whakamahia ki te rongoa i nga mate rewharewha kua whakaaetia mo te hoko.Ko te Roflumilast te rongoa tuatahi o tona momo ki te aro ki te mate pukupuku obstructive pulmonary (COPD), a koinei hoki te rongoa aukati-waha tuatahi i hangaia mo nga turoro COPD.Ka taea e ona ahuatanga ahurei te awhina ki te whakahaere COPD: ka whakamahia tahi me nga bronchodilators ki te rongoa i nga turoro COPD tino kino, ka whai hua a Roflumilast ki te whakaheke ake i nga tohu me te tere o te paheketanga, na reira ka waiho ko te rongoa tuatahi e aro ana ki nga turoro me te mate haere tonu o te phenotype-spAecific COPD. me te aukatinga nui o te rere o te hau e pa ana ki te maremare mau tonu me te nui o te kohu.I tua atu i te maimoatanga mo te COPD kino, ka taea hoki te whakamahi a Roflumilast ki te aukati me te rongoa i nga mate o te rewharewha o nga kararehe, te maremare mucosa bronchitis te taikaha, te bronchitis huango, me te bronchitis whakapeka me te hau sacculitis e haere tahi ana me te hunanga o te rewharewha rereke.