Sitagliptin Phosphate Monohydrate CAS 654671-77-9 Purity >99.0% (HPLC) API Factory Kounga Teitei
Whakaratohia nga Kaiwaenga e Pa ana ki te Sitagliptin Phosphate Monohydrate:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Waikawa CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Wakawa Butyric CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Takawaenga CAS 486460-21-3
Ingoa matū | Sitagliptin Phosphate Monohydrate |
Nga kupu taurite | (R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4- (2,4,5-trifluorophenyl)butana-1-kotahi phosphate monohydrate |
Tau CAS | 654671-77-9 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C16H20F6N5O6P |
Taumaha rāpoi | 523.3240802 |
Iwi Whakarewa | 202.0~204.0 ℃ |
Wairewa wai | Wairewa ki te wai |
Hurihuri Tauwhāiti | -18.0°~-23.0° (C=1, Wai) |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura Tioata-White |
Te tautuhi na HPLC | Ko te wa pupuri o te tauira he rite ki te paerewa tohutoro |
Hiranga IR-Poikākā | Ko te IR Absorption Spectrum o te tauira kia rite ki tera o te awhi paerewa |
Phosphate | Ka tutuki |
Te Maama / Tikanga Tatauria | >99.0% (HPLC i runga i te tikanga maroke) |
Ihirangi wai (KF) | 3.3%~4.4% |
Te toenga i runga i te mura | ≤0.20% |
pūkawa | ≤0.02% |
pūhaumāota | ≤0.05% |
Te poke o Chiral | <0.50% |
Nga Taonga Paanga | |
Te poke kotahi | <0.50% |
Nga poke katoa | <1.0% |
Ethyl Acetate | <0.50% |
Nga Korewa Taamaha | <20ppm |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | Takawaenga Rongoa |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.
Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9), he rongoa hou mo te maimoatanga o te mate huka momo 2.I te marama o Akuhata 2009, i whakaaetia te tarukino e te Kotahitanga o Europi hei rongoa rarangi tuatahi mo te maimoatanga o te mate huka momo 2.Ko te Sitagliptin Phosphate te aukati tuatahi o te dipeptidyl peptidase-IV kua whakaaetia e te FDA hei whakamahi mo te maimoatanga o te mate huka momo 2 i tawhiti, i raro i te ingoa hokohoko Januvia.Ko te Dipeptidylpeptidase Ⅳ (DPP-Ⅳ) ka tere me te whai hua te whakaheke i te GLP-1, GLP-1, ko te tino whakaongaonga o te hanga insulin me te hunanga Na reira, ka taea e te aukati o DPP-IV te whakarei ake i te mahi o te GLP-1 endogenous, na reira ka piki ake te toto. nga taumata o te insulin, na reira ka whakaheke me te pupuri i nga taumata huka toto i roto i nga turoro mate huka.I tenei wa, kua whakapumautia e te rongoa ko te aukati DPP-IV he momo hou mo te rongoa mate huka, a ko nga hua haumanu e whakaatu ana he pai te hua hypoglycemic o nga raau taero.Na te mea ko te GLP-1 he mahi e whakawhirinaki ana ki te hukahuka ki te whakatairanga i te whakangao me te hunanga o te insulin, karekau nga tauhohenga kino penei i te hypoglycemia me te pikinga o te taumaha na te whakamahi i nga raau taero antidiabetic.