Sorafenib Tosylate CAS 475207-59-1 Purity ≥99.0% (HPLC) API Factory Kounga teitei
Hoatu Arumoni Sorafenib Tosylate me nga Takawaenga Paanga:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Ingoa matū | Sorafenib Tosylate |
| Nga kupu taurite | Nexavar;4-[4-[3-[4-Chloro-3-(Trifluoromethyl)phenyl]ureido]phenoxy]-N-Methylpicolinamide 4-Methylbenzenesulfonate;4-[4-[[4-Chloro-3-(Trifluoromethyl)phenyl]carbamamido]phenoxy]-N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Tau CAS | 475207-59-1 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C21H16ClF3N4O3.C7H8O3S |
| Taumaha rāpoi | 637.03 |
| Iwi Whakarewa | 225.0 ki te 230.0 ℃ |
| Tairongo | Te Hau, Te wera |
| Wairewa | Wairewa i te wai (<1 mg/ml) i te 25 ℃, DMSO (127 mg/ml ) i te 25 ℃, me te Ethanol (<1 mg/ml ) i te 25 ℃ |
| Nga Tikanga Tukunga | Wahi Matao me te maroke (2~8 ℃), Tiaki i te Maama |
| COA & MSDS | Kei te waatea |
| Te Ora Papa | 2 Tau ki te rongoa tika |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga | Hua |
| Te ahua | Kowhai Maama, Paura Ma ranei | Ka tutuki |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) | 99.8% |
| Iwi Whakarewa | 225.0~230.0 ℃ | Ka tutuki |
| Nga Korewa Taamaha | ≤10ppm | <10ppm |
| Ngaronga i te whakamaroke | ≤0.50% | 0.12% |
| Te toenga i runga i te mura | ≤0.20% | 0.10% |
| Tetahi poke kotahi | ≤0.50% | Ka tutuki |
| Nga poke katoa | ≤0.50% | Ka tutuki |
| NMR Spectrum | He rite ki te Hanganga | Ka tutuki |
| Paerewa Whakamatau | Paerewa hinonga | Ka tutuki |
| Whakamahinga | Sorafenib Tosylate (CAS: 475207-59-1) i te maimoatanga o te RCC & HCC | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Rokiroki i roto i te ipu kati kati.Rokiroki i roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Waehere Whakararuraru 36/37/38 - He whakapataritari ki nga kanohi, te punaha manawa me te kiri.
Whakaahuatanga Haumaru S28 - I muri i te pa ki te kiri, horoi tonu me te maha o te hopi-hu.
S26 - Mena ka pa ki nga kanohi, horoi tonu ki te nui o te wai me te rapu tohutohu hauora.
Ko te Sorafenib Tosylate (CAS: 475207-59-1) he momo hou o te raau taero antitumor maha, i whakawhanakehia e te Tiamana Bayer Pharmaceuticals, me te whakaatu i nga mahi antitumor whanui i roto i nga whakamatautau kararehe preclinical.Kei te waatea a Sorafenib i roto i nga papa 200-mg mo te whakahaere a-waha ka whakamahia ki te maimoatanga o te RCC me te HCC.Ka taea e Sorafenib Tosylate te pa i te wa kotahi ki nga pūtau puku me nga oko toto puku.He huanga antitumor rua: ka taea e ia te aukati i nga huarahi whakawhiti tohu tohu pūtau i takawaengahia e te RAF/MEK/ERK ki te aukati tika i te tipu o te pūtau puku, me te aukati ano i te VEGF me nga kaiwhakawhiwhi tohu tipu (PDGF) hei aukati i te hanganga o te toto puku hou. nga oko, na reira ka aukati i te tipu o nga pūtau puku.
Sorafenib Tosylate, ingoa hokohoko Nexavar, i whakawhanakehia tuatahi e Bayer Pharmaceuticals i Germany.Ko te Sorafenib Tosylate he aukati maha-kinase ka taea te whakamahi ki te rongoa i nga mate penei i te mate pukupuku.I te Hakihea 2005, i whakaaetia e te US FDA hei rongoa rarangi tuatahi mo te maimoatanga o te mate pukupuku renal.I te marama o Akuhata 2009, i whakaingoatia te rarangi ingoa ki Haina me te whakaaetanga a te Mana Whakahaere Kai me te Taakaro.
Ko te Sorafenib Tosylate he tyrosine kinases (VEGFR me PDGFR) me RAF/MEK/ERK cascade inhibitors, e mahi ana i te wa kotahi i runga i te Raf-1, wtBRAF me V599EBRAF, me te IC50 o 6 nM, 22 nM me 38 nM, ia.
Ka taea e te Sorafenib Tosylate te whakakore i nga momo kinase kei runga i te pūtau me te mata o te pūtau, tae atu ki te RAF kinase, vascular endothelial growth factor receptor-2 (VEGFR-2), vascular endothelial growth factor receptor-3 (VEGFR-3), platelet -i ahu mai i te tauwehe tupu kaikawe-β (PDGFR-β), KIT me FLT-3.Ka kitea ko te sorafenib toluenesulfonate e rua nga paanga anti-puku.I tetahi taha, ka taea e ia te whakakore tika i te tipu o te pukupuku ma te whakakore i te huarahi tohu RAF / MEK / ERK;i tetahi atu ringa, ka taea te aukati i te VEGFR me te PDGFR.A ka aukati i te hanganga o te neovascularization puku, autaki tautāwhi i te tupu o ngā pūtau puku.Ko te Sorafenib Tosylate te rongoa tino whai hua mo te maimoatanga o te mate pukupuku ate ahu whakamua ma te whakahaere punaha, a tera pea ka noho hei rongoa hou mo te maimoatanga o tenei mate.
Ko te Sorafenib Tosylate i ia ra te whakahaere a-waha o nga tauira whakawhiti kararehe puku tangata i whakaatu i te whānuitanga o nga mahi anti-tumor, tae atu ki te mate pukupuku o te koroni, te mate pukupuku kore-iti, te mate pukupuku o te uma, te melanoma, te mate pukupuku pancreatic, te reukemia me te mate pukupuku ovarian me te kiore renal cell carcinoma. tauira, tauira RENCA.
