Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV Kounga Teitei
Tautoko Aromoni Tenofovir Takawaenga:
Tenofovir CAS: 147127-20-6
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Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
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Diethyl (Hydroxymethyl)phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
Ingoa matū | Tenofovir Alafenamide Hemifumarate |
Nga kupu taurite | TAF;GS-7340 Hemifumarate |
Tau CAS | 1392275-56-7 |
Tau CAT | RF-API91 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C25H33N6O9P |
Taumaha rāpoi | 592.55 |
Paemahana Rokiroki | Hirihia ki te maroke, te pāmahana rūma |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Maama ki te Tata Maama Tioata, Tioata Paura ranei |
Wairewa | Wairewa i roto i te Dimethylformamide, me te Methanol;He iti te wairewa ki te wai me te THF;He iti te whakarewa i roto i te Acetonitrile me te Insoluble i te Dichloromethane me te Toluene |
Tautuhi A | Ko te IR absorption spectrum kia rite ki te tohutoro |
Tautuhinga B | Ko te wa pupuri o te tihi nui o te otinga tauira i roto i te chromatogram whakatau ihirangi e rite ana ki tera o te otinga tohutoro |
Tautuhinga C | Ko te wa pupuri Waikawa Fumaric o te tihi nui i roto i te chromatogram whakatau ihirangi e rite ana ki te tihi o te tohutoro. |
Ihirangi Wai (na KF) | ≤1.0% |
Maramatanga o te Otinga | Ko te tikanga karekau he matūriki e kitea ana i roto i te 2% (w/v) o te whakamarama Methanol Solution |
Wairewa toenga | |
Acetonitrile | ≤410ppm |
Ewaro | ≤5000ppm |
Dichloromethane | ≤600ppm |
Toluene | ≤890ppm |
Te toenga i runga i te mura | ≤0.10% |
Nga Korewa Taamaha | ≤20ppm |
Nga Taonga Paanga | |
PMPA | ≤1.0% |
PMPA Anhydride | ≤0.75% |
Phenyl PMPA kotahi | ≤1.0% |
Tetahi poke kore i tohua | ≤0.15% |
Nga poke katoa | ≤2.0% |
Isomer | ≤1.0% |
Te ihirangi o te Waikawa Fumaric | 9.0%~13.0% (i runga i te tikanga kore) |
Nga Tepe Microbial | |
Tatau Moroiti Aerobic Tapeke | ≤1000CFU/g |
Tatau Rewena me nga Maaka | ≤100CFU/g |
Escherichia Coli | Kei te ngaro |
Te whakamatautau | 98.0%~102.0% (i runga i te waikore me te whakarewa-kore) |
Paerewa Whakamatau | Paerewa hinonga |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, he nucleotide reverse transcriptase inhibitor (NRTIs) me te prodrug pukapuka o Tenofovir (TFV).Ma te aukati i te whakamuri transcriptase, ka aukati te TAF i te mate HIV kia nui haere, ka taea te whakaiti i te nui o te HIV i roto i te tinana.Ko te Tenofovir alafenamide he prodrug, ko te tikanga he rongoa kore mahi.I roto i te tinana, ka huri te tenofovir alafenamide ki Tenofovir diphosphate (TFV-DP).I whakaaetia a Tenofovir Alafenamide Fumarate i te marama o Noema 2015 mo te maimoatanga o te HIV-1.