trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity >98.0% (HPLC) Afatinib Dimaleate Intermediate

Whakaahuatanga Poto:

trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Maamaa: >98.0% (HPLC)

Te ahua: Ma ki te paura tata ma

Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Whakapā: Takuta Alvin Huang

Pūkoro/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Tukuna he imeera ki a matou

Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	trans-4-Dimethylaminocrotonic Acid Hydrochloride
Nga kupu taurite	trans 4-Dimethylaminocrotonic Acid HCl;(E)-4-(Dimethylamino)-2-Butenoic Acid Hydrochloride;(E)-4-Dimethylaminocrotonic Acid Hydrochloride;(2E)-4-(Dimethylamino)engari-2-Enoic Acid Hydrochloride;Afatinib int-2
Tau CAS	848133-35-7
Tūnga Taonga	Kei roto i nga taonga, Tauine Aromoni
Tātai rāpoi	C6H12ClNO2
Taumaha rāpoi	165.62
Te tairongo	Hygroscopic.Makuku Tairongo
Iwi Whakarewa	160.0 ki te 164.0 ℃
Wairewa	DMSO (Paku), Methanol (Paku), Wai (Paku)
COA & MSDS	Kei te waatea
Taketake	Shanghai, Haina
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te paura tata ma
Te Maama / Tikanga Tatauria	>98.0% (HPLC)
Te Maama / Tikanga Tatauria	>98.0% (NMR)
makuku (KF)	<0.50%
Te toenga i runga i te mura	<0.20%
Te poke kotahi	<0.50%
Konga Taamaha (hei Pb)	<20ppm
Spectrum Infrared	He rite ki te Hanganga
1 H NMR Spectrum	Proton NMR Spectrum
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Afatinib, Afatinib Dimaleate

Mōkī me te Rokiroki:

Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.

Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.

Pure Chromatographic:

Taputapu: Agilent 1200 HPLC HPLC chromatograph, DAD detector.
Tīwae: Agilent XDB-C18,250*4.6mm, 5μm
Wāhanga pūkoro: B: 1.95g konutai octane sulfonate + 8ml waikawa phosphoric + 5ml triethylamine + 500ml wai
C: acetonitrile
Te takanga o te wahanga pūkoro whakauru: tango 400ml B otinga me te 100ml acetonitrile, uru pai me te taurite, ka pupuhi i te wai ki te wahanga kotahi.
Rere rere: 0.5ml/min54bar
Te pāmahana tīwae: 25℃
Te roangaru: 210nm
Tauira otinga: i whakamahia te wahanga pūkoro hei whakarewa, tauira totoka: 0.0040g/2ml, te rahi tauira 2.0μl.

Painga:

FAQ:

Taupānga:

Ko te trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) he reagent e whakamahia ana i roto i te whakarite o te tyrosine kinase inhibiting antitumor agents.Ka taea te whakamahi i te trans-4-Dimethylaminocrotonic Acid Hydrochloride hei takawaenga o Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Ko te Afatinib he rongoa kua whakaaetia mo te maimoatanga o te mate pukupuku pukupuku kore-iti (NSCLC), i hangaia e Boehringer Ingelheim.Ka mahi hei aukati angiokinase.Pērā i a Lapatinib me Neratinib, ko te Afatinib he aukati tyrosine kinase (TKI) e kore e taea te whakakore i te tangata epidermal growth factor receptor 2 (Her2) me te epidermal growth factor receptor (EGFR) kinases.Ko te Afatinib ehara i te kaha ki te EGFR anakeko nga huringa e whaaia ana e nga TKI reanga tuatahi penei me te gefitinib me te gefitinib, engari ki te hunga kaore e aro ki enei rongoa paerewa.Na tana mahi taapiri ki a Her2, kei te whakatewhatewhahia mo te mate pukupuku uma me etahi atu mate pukupuku EGFR me Her2.Ko te Neratinib i whakawhanakehia e te kamupene US Wyeth he aukati epidermal growth factor receptor(EGFR) e kore e taea te huri.He waahi whainga maha o nga ngongo iti ngota tyrosine kinase inhibitors ki te HER 2 me te HER1 i muri i te Lapatinib, a, he aukati ErbB receptor tyrosine kinase e kore e taea te huri.Ka taea e Neratinib te whakakore i te HER-1 me te HER-2 o te whanau EGFR (ko te IC50 he 92 nmol/L me te 59 nmol/L, ia).I kitea e te rangahau haumanu he nui te kaha whakaora a Neratinib ki runga i te mate pukupuku o te puku kore-iti, te mate pukupuku kopirua, me te mate pukupuku uma.Ko te whakamatautau haumanu o te wahangaⅡ i whakaatu ko Neratinib te pai o te kaha me te manawanui ki nga turoro HER-2 pai ki te mate pukupuku mate pukupuku kua whiwhihia, kaore ranei i te maimoatanga Trastuzumab.Ko te wahanga Ⅲ te whakamatautau haumanu mate pukupuku uma i oti i te Mahuru 2014.