Huaora E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o Huaora E-TPGS (Tocofersolan) (CAS: 9002-96-4) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hoko Huaora E-TPGS,Please contact: alvin@ruifuchem.com
| Ingoa matū | Huaora E Polyethylene Glycol Succinate |
| Nga kupu taurite | Huaora E-TPGS;TPGS;Tokofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-α-Tocopherol Polyethylene Glycol 1000 Succinate;alpha-Tocopherol Polyethylene Glycol Succinate |
| Tūnga Taonga | Kei roto i nga taonga, Tauine Aromoni |
| Tau CAS | 9002-96-4 |
| Tātai rāpoi | C33H54O5.(C2H4O)n |
| Iwi Whakarewa | 34.0~38.0℃ |
| Kiato | 1.01g/cm3 |
| Tairongo | Te Hau, Te Maama, Te Makuku |
| WGK Tiamana | 2 |
| Rokiroki Temp. | Wahi Matao me te maroke (2~8℃) |
| COA & MSDS | Kei te waatea |
| Tauira | Kei te waatea |
| Whanau Chemical | Huaora E pärönaki |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Maama-Ma ki te Koma Kowhai Waxy Solid | Ka tutuki |
| Tautuhinga (GC) | Ko te wa pupuri o te tihi nui o te otinga tauira e rite ana ki tera o te otinga Paerewa | Ka tutuki |
| Iwi Whakarewa | 34.0~38.0℃ | 36.0~36.6℃ |
| Te whakamatautau D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Tocopherol kore utu | ≤1.5% | Ka tutuki |
| Hurihuri Tauwhāiti | ≥+24.0° | +24.5° |
| Wairewa i te wai | 20g Tauira Ka taea te Whakarewa i roto i te 80ml te wai kohua | Mārama I roto i te 3 h |
| Uara Waikawa | ≤0.27ml (0.10 N Sodium Hydroxide) | 0.22ml |
| Konga Taamaha (Pb) | ≤10ppm | <10ppm |
| Arsenic (As) | ≤1ppm | <1ppm |
| Arataki | ≤3ppm | <3ppm |
| Mercury (Hg) | ≤0.1ppm | <0.010ppm |
| Wairewa toenga | ||
| Ethyl Acetate | ≤50ppm | Kaore i kitea |
| Ewaro | ≤50ppm | 23ppm |
| Tatau Pereti Tapeke | ≤1000CFU/g | <10CFU/g |
| Rewena me nga Maaka | ≤100CFU/g | <10CFU/g |
| Haramona | He kino | He kino |
| Escherichia Coli | He kino | He kino |
| Psendomonas Aeruginosa | He kino | He kino |
| Staphylococcus Aureus | He kino | He kino |
| Spectrum Infrared | He rite ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Rokiroki i roto i te ipu kati kati.Rokiroki i roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
WHAKAMAHI
Huaora E Ko te Polyethylene Glycol Succinate he ranunga i hangaia e te whakamaaramatanga o te d-alpha tocopheryl acid succinate me te polyethylene glycol.Ko te ranunga hākawa ko te polyethylene glycol mono-esterified me te iti o te polyethylene glycol di-esterified.Kei roto te NLT 25.0% o te d-alpha tocopherol (C29H50O2).
WHAKATAUTANGA
• A. Te Whakamatau Identification Chromatographic Gas
Tātaritanga: Haere tonu i roto i te whakamatautau mo te Ihirangi o te Alpha Tocopherol.
Paearu whakaae: Ko te wa pupuri o te tihi nui o te otinga Tauira e rite ana ki tera o te otinga Paerewa.
KAUPAPA
• Ihirangi o Alpha Tocopherol
Wairewa: 0.25 mL o te phenolphthalein TS i roto i te 1 L o te waipiro
Te otinga paerewa o roto: 12 mg/mL o te ethyl arachidate i roto i te isooctane
Te otinga paerewa: Whakawhitihia te 32.5 mg o te USP Alpha Tocopherol RS ki te ipu tauhohenga pai.Tāpirihia te 2 mL o te pyridine me te 0.5 mL o te N,O-bis(trimethylsilyl)trifluoroacetamide me te 1% trimethylchlorosilane, ka whakamahana i te ipu i te 100 mo te 10 meneti.Whakamaohia te ipu, tāpirihia te 5.0 mL o te wairewa paerewa o roto ka whai i te 20 mL o te isooctane, ka ruru.
Tauira otinga: Whakawhitihia he rahinga e rite ana ki te 0.100–0.160 g Huaora E Polyethylene Glycol Succinate kua whakarewahia i te 60 ki te ngongo ahurea (tata ki te 20 cm te roa me te 2.5 cm te whanui) kua mau ki te potae wiri.Tāpirihia he 40–50 mg o te waikawa ascorbic me etahi maramara kohua, ka whai i te 20 mL o te Wairewa.[Tuhipoka—Tukuhia marietia te otinga kia kore e puta nga ihirangi.] Whakanohoia te ngongo ki roto i te paraka whakamahana i te 100–150.Ka rewa katoa te tauira, tāpirihia te 0.25 g pāhare pāporo waihā, ka haere tonu ki te reflux mo te 30 min.Tangohia te ngongo mai i te wera, a, i te wa e wera tonu ana nga mea o roto, taapirihia te 1-2 mL o te waikawa maatawai kia kore ra ano te tae mawhero.[Tupato—Te tauhohenga Exothermic.Tukua kia rere te waikawa ki roto o te ngongo kia kore ai e pakaru.] Mataohia te ngongo, ka horoi i nga taha o te ngongo ki te 20 mL wai.Tāpirihia te 5.0 mL o te otinga paerewa o roto, te potae, me te ruru kia pai te whakaranu.Tukua kia tu te ngongo kia puta ra ano nga papa e rua.Whakawhitihia te 2.5–3.5 mL o te paparanga o runga ki roto i te ipu tauhohenga pai, ka tapirihia te 2.0 mL o te pyridine me te 2.5 mL o te N,O-bis(trimethylsilyl) trifluoroacetamide me te 1% trimethylchlorosilane.Whakawerahia te ipu ki te 100 mo te 10 min.Matao, katahi ka tapirihia te 12 mL o te isooctane.
Pūnaha Chromatographic
(Tirohia Chromatography 621, Pūnaha Whakaritenga.)
Aratau: GC
Kaipupuri: Te katote mura
Tīwae: 0.25-mm × 15-m te kapi-silica tuitui;kua whakakikoruatia ki te kiriata 0.25-µm o te wahanga G27
Te pāmahana
Injector: 280
Kaitirotiro: 345
Tīwae: Tirohia te Ripanga 1.
Ripanga 1
Te Pawera Tuatahi(°) Te Paemahana Ramp (°/min) Te Wehana Whakamutunga (°) Te Waa Pumau i te Waahi Whakamutunga (min)
260 20 340 1
Te hau kawe: Helium
Rere rere: 1.5 mL/min
Rahi werohanga: 1 µL
Momo werohanga: Wehea ōwehenga, 200:1
Te pai o te punaha
Tauira: otinga Paerewa
Nga whakaritenga e tika ana
Tauwehe hiako: NMT 2.0 mo te tihi alpha tocopherol
Te inenga paerewa whaitake: NMT 2.0% mo te ōwehenga o te rohe tihi alpha tocopherol ki te rohe tihi paerewa o roto
Tātaritanga
Tauira: Te otinga Paerewa me te Tauira Tauira
Tātaihia te ōrau o te d-alpha tocopherol (C29H50O2) i te wahanga o te Huaora E Polyethylene Glycol Succinate i tangohia:
Hua = (RU/RS) × (WS/WU) × 100
RU= ōwehenga paerewa ā-roto (rohe teitei o te alpha tocopherol/rohe tihi o te paerewa o roto) mai i te Tauira otinga
RS= ōwehenga paerewa ā-roto (te horahanga teitei o te alpha tocopherol/te waahi tihi o te paerewa o roto) mai i te otinga Paerewa
WS= te taumaha o te USP Alpha Tocopherol RS i whakamahia hei whakarite i te otinga Paerewa (mg)
WU= te taumaha o te Huaora E Polyethylene Glycol Succinate i tangohia hei whakarite i te Tauira otinga (mg)
Paearu whakaae: NLT 25.0%
NGA WHAKAMATAUTANGA
• Te Hurihanga Mata, Te Hurihanga Motuhake 781S
[Tuhipoka-Ko tenei whakamatautau ka tautuhi i te d-alpha tocopherol i muri i te saponification.]
Tauira otinga: Whakawhitihia te 0.9 kara o te Huaora E Polyethylene Glycol Succinate, kua whakarewahia ki te 60, ki tetahi ipuipu whakamatautau pai kua whakauruhia ki te potae, ka memeha ki te 10.0 mL o te waipiro.Whakanohoia te ngongo ki roto i te paraka whakawera i te 100–105.[Tuhipoka-Whakatahurihia te otinga kia kaua e puta te ihirangi.] Ka rewa katoa te tauira, taapirihia kia 2-3 pire konutai konutai, ka haere tonu ki te reflux mo te 30 meneti atu.Tangohia te ngongo mai i te wera, a, i te wa e wera tonu ana nga mea o roto, whakakorehia ma te whakamahi i te phenolphthalein hei tohu ma te ata taapiri i te 10 mL o te ranunga wai me te waikawa waikawa (1:1) kia ngaro ra ano te tae mawhero.[Tupato-Tauhohenga tauhohenga.Tukua te wairewa waikawa kia taheke ki roto o te ngongo kia kore ai e pakaru.] Whakamaohia te ngongo, te potae, me te ruru kia uru pai nga mea o roto.Tāpirihia he 25.0 mL heptane, potae, ka ruru mo te 1 meneti kia pai te whakaranu.Tukua kia tu te ngongo kia puta ra ano nga papa e rua.Whakawhitihia te paparanga o runga ki te ngongo ahurea ma, maroke, katahi ka tapirihia te 10.0 mL wai ki te wairewa whakaora.Kapohia, ka ruru, ka tuku kia wehe nga paparanga.Whakawhitihia te paparanga o runga ki te ngongo ma, maroke.Tāpirihia te 10.0 mL o te wairewa pāhare pāporo ferricyanide, kua whakaritea ma te whakakore i te 2 g pāhare pāporo ferricyanide ki te 10.0 mL o te 0.2 M konutai waihā, ka whakakapi i te pōtae.Kia kaha te wiri mo te 45 s, ka waiho kia wehe nga paparanga mo te 30 min.Mena he maamaa te paparanga heptana o runga, haere tonu ki te ine mo te hurihanga motuhake;ki te kore e marama, whakamaroke ki runga i te konutai konutai whakakawa i mua i te haere ki te whakamatautau.[Tuhipoka-Whakamahia nga hua o te whakamatautau mo te Ihirangi o te Alpha Tocopherol hei tatau i te hurihanga motuhake.]
Paearu whakaae: NLT +24.0
• Te Wairewa i te Wai
Tauira: 20 g Huaora E rewa Polyethylene Glycol Succinate
Tātaritanga: Whakanohoia te Tauira ki roto i te ipu karaihe ki runga i te whakaoho autō.Tonu 80 mL o te wai kohua i te wa e whakakorikori ana.Tukua kia whakamatao ki te pāmahana rūma me te whakaoho tonu.
Paearu whakaae: Ka marama te otinga i roto i te 3 haora.
• Uara Waikawa
Tauira: 1 g Huaora E Polyethylene Glycol Succinate
Tātaritanga: Whakarewahia te Tauira ki te 25 mL o te ranunga o te waipiro me te etera (1:1) kua whakakorehia ki te phenolphthalein me te 0.1 N konutai waikawa.Tāpirihia te 0.5 mL o te phenolphthalein TS, ka titrate ki te 0.10 N konutai waihā kia noho māwhero te wairewa i muri i te wiri mo te 30 hēkona.
Paearu whakaae: NMT 0.027 mEq/g, he rite ki te NMT 0.27 mL o te 0.10 N konutai waikawa.
HE WHAKAMAHI ATU
• Whakapaipai me te Rokiroki: Purihia ki roto i nga ipu kiki, ka tiakina mai i te marama.
• Te Tapanga: Ko te tapanga e tohu ana i te ihirangi d-alpha tocopherol, kua whakaatuhia ki te mg/g.
• Paerewa Tohutoro USP 11
USP Alpha Tocopherol RS
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
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KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
Huaora E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) he hua waihanga.E waatea ana hei maa-ma-ma-ma-ma-ma-ma-ma-ma-ma-ma-ma-ma-mao ki te kowhai-kowhai-kowhai-waxy Solid, a, he ahua kore noa.Ko te tikanga matū, he ranunga i titoa te nuinga o te polyethylene glycol monoesterified 1000, te polyethylene glycol 1000 diesterified, polyethylene glycol 1000 kore utu, me te tocopherol kore utu.
Huaora E Polyethylene Glycol Succinate kua whakamahia whānuitia i roto i te rangahau ho'oraa, hei solubilizer, kaiwhakatairanga absorption, emulsifier, plasticizer me te kawe o te punaha tuku tarukino wai-kore, ngako wairewa ranei, penei i te whakamararatanga totoka, te kawe mo te tuku tarukino mata, te kawe mo te intranasal. tuku tarukino, aha atu Hei taapiri kai.
Huaora E Ko te Polyethylene Glycol Succinate he wairewa-wairewa o te huaora E, he mea hanga ma te tauhohe i te roopu carboxyl o te huaora E succinate me te roopu hydroxyl o te polyethylene glycol.No te mea kei roto e rua te huaora E lipophilic roopu me te polyethylene glycol hydrophilic mekameka roa, he pai nga ahuatanga o te surfactant me te wairewa wai, ka tino whakanui ake i te whakauru o nga raau taero kore i roto i te kohanga o te kopu, ka nui ake te koiora.
I nga tau kua pahure ake nei, he maha nga rangahau kua kitea ko te TPGS ehara i te mea ka taea te whakamahi hei rongoa rongoa, engari he maha ano nga ahuatanga ahurei, hei whakanui i te whakauru me nga kaihoko whakamuri aukati maha, ka taea hoki te whakamahi i te TPGS ki nga prodrugs, micelles, liposomes, TPGS-copolymer. kawe ki te whakapai ake i te memehatanga, uruhanga me te pūmautanga o te faaineineraa, kia rite ki te whakatutuki puhoi, mana tuku me te whai pānga, whakatairanga i te absorption o raau taero.
1. Rongoa - Huaora E-TPGS ka tino whakarei ake i te whakaurunga, te waatea me te whaihua o nga kai rongoa (API)
2. Nga taapiri kai - Ka whakamahia te Huaora E-TPGS ki te hanga i nga taapiringa, ina koa ko nga mea i hangaia hei whakapai ake i te whakaurunga o te huaora E me etahi atu matūkai lipophilic me nga huaora.
3. Kai me te Inu - Ka taea te whakamahi Huaora E-TPGS ki te whakapakari i nga kai me nga inu, nga inu hakinakina, te wai me te wai.
4. Tiaki Whaiaro - Ko te Huaora E-TPGS te mahi hei whakamohoatanga kore-kore, hypoallergenic, kore-whakararuraru i roto i te tiaki whaiaro me nga tono whakapaipai.
5. Hua Kai Kai Kararehe - Ko te Huaora E-TPGS he whakarato i te huaora E tino morohia me te waatea mo nga kararehe kaore i te pai te tango i nga momo huaora E tuku iho.
Ko te Huaora E polyethylene glycol succinate he huaora E (tocopherol) kua whakamaarama i te nuinga o te whakamahi hei kaiwhakarewa, hei whakaemi whakaemi ranei na te mea na ona ahuatanga haumanu.Ko te hanganga, he amphipathic me te hydrophilic, kaore i rite ki nga tocopherols, na reira he pärönaki wairewa-wai ka taea te whakamahi i roto i nga waihanga rongoa penei i te capsules, papa, extrusion wera-rewa, microemulsions, hua kaupapa, me te parenterals.Ko tetahi o nga tono tino nui ko tana whakamahi hei waka mo nga hanganga tuku tarukino e pa ana ki te lipid.Ka taea hoki te whakamahi hei puna huaora E. Huaora E polyethylene glycol succinate kua tohuhia mo tana tikanga mahi me te ako hei aukati Pglycoprotein.
Ko te huaora E polyethylene glycol succinate he hotokore ki nga waikawa kaha me nga kawakore kaha.
GRAS kua whakarārangihia.Kei roto i te Raraunga Raraunga Inactive Ingredients FDA (te otinga ophthalmic, pata ranei; capsules-waha, otinga, papa; otinga kaupapa, pata ranei).Kei roto i te Rarangi Kanata mo nga Kai-kore-rongoa e whakaaetia ana.
