Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Kounga Teitei
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Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Ingoa matū | Vonoprazan Fumarate |
| Nga kupu taurite | TAK-438 |
| Tau CAS | 1260141-27-2;881681-01-2 |
| Tau CAT | RF-API99 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C21H20FN3O6S |
| Taumaha rāpoi | 461.463 |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura Maama, Tata-Whiti ranei |
| Tautuhinga 1 H-NMR | E rite ana ki te Paerewa |
| Tautuhinga IR | Ko te IR Absorption spectrum o te tauira riterite ki te paerewa tohutoro |
| Tautuhinga HPLC | Te wa pupuri o te tauira riterite ki te paerewa tohutoro |
| Ihirangi wai | ≤0.50% |
| Te toenga i runga i te mura | ≤0.20% |
| Konga Taamaha (hei Pb) | ≤20ppm |
| Nga Taonga Paanga | |
| Te poke A | ≤0.20% |
| Te poke B | ≤0.15% |
| Te poke C | ≤0.15% |
| Tetahi atu poke | ≤0.10% |
| Nga poke katoa | ≤1.0% |
| Wairewa toenga | |
| Mewaro | ≤0.30% |
| Ewaro | ≤0.50% |
| Ethyl Acetate | ≤0.50% |
| Tikanga Whakamatau / Tatau | 98.0%~102.0% (Na HPLC) |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | API |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama, i te makuku.
Ko te Vonoprazan Fumurate (TAK-438) (CAS: 1260141-27-2; 881681-01-2), he aukati papu iraoho (PPI), he kaha, he kaha hoki te kaha o te waha i te paraka waikawa konupora-whakataetae (P-CAB), me te antisecretory. mahi.Ko te Vonoprazan Fumarate te aukati i te mahi H+,K+-ATPase i roto i nga microsomes pekitia porcine me te IC50 o 19 nM i te pH 6.5.Ko Vonoprazan Fumarate (Takecab), i kitea, i whakawhanakehia e Takeda me Otsuka, i whakaaetia e te PMDA o Japan i te Hakihea 2014. Ko te Vonoprazan Fumarate te nuinga o te whakamahinga mo te maimoatanga o te mate helicobacter pylori, te reflux gastroesophageal, te mate pukupuku, te whewhe duodenal, te esophagitis, te kopu. whewhe me etahi atu mate e pa ana ki te waikawa puku.Ko te hua he kaha, he mau tonu te aukati i te whakaputanga waikawa pekitīlia.I te horopeta maimoatanga, he iti noa te paanga o Vonoprazan Fumarate ki etahi atu enzymes me te iti o te paanga ki nga mahi a-tinana o te tinana.He haumaru me te pai ake.
