Zoledronic Acid CAS 118072-93-8 Purity ≥99.7% API Factory Kounga teitei
Whakarato me te Maama me te Kounga Pumau
Ingoa matū: Zoledronic Acid
CAS: 118072-93-8
He kaha te Farnesyl Diphosphate (FPP) Synthase Inhibitor
API Kounga Teitei, Hanganga Tauhokohoko
Ingoa matū | Waikawa Zoledronic |
Nga kupu taurite | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene] waikawa bisphosphonic |
Tau CAS | 118072-93-8 |
Tau CAT | RF-API90 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C5H10N2O7P2 |
Taumaha rāpoi | 272.09 |
Iwi Whakarewa | 193.0~204.0 ℃ |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura Tioata-White |
Tautuhinga | IR Spectrum o te tauira e rite ana ki tera o te paerewa tohutoro |
pH | 2.0~4.0 |
Wairewa | He iti te whakarewa i roto i te 0.1N Sodium Hydroxide Solution, He Iti Rere ki te Wai me te 0.1N Waiwai Putakawa, Tata Karekau i te Ewaro |
Nga Taonga Paanga | |
Te poke takitahi | ≤0.10% |
Nga poke katoa | ≤0.30% |
Ngaronga i te whakamaroke | 5.0%~7.0% |
pūhaumāota | ≤0.02% |
Phosphite | ≤0.50% |
Phosphate | ≤0.50% |
Nga Korewa Taamaha | ≤10ppm |
Maamaa | ≥99.7% |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | API, FPP Synthase Inhibitor, Hypercalcemia of malignancy (HCM) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
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Ko te waikawa Zoledronic (CAS 118072-93-8) he kaha te aukati synthase bisphophonate farnesyl diphosphate (FPP) (IC50=20 nM).Ka aukati i te resorption o nga wheua i waenga i te osteoclast.Ka aukati ano i te tohu Ras me te tipu puku, me te whakaawe i te apoptosis i roto i nga pūtau mate pukupuku pancreatic.Ka huri i te whakawhitinga epithelial-mesenchymal me te aukati i te whakahoutanga o nga pūtau mate pukupuku u ma te whakakore i te NF-κB.Ko te waikawa Zoledronic i whakamanahia e te US FDA i te tau 2001 mo te maimoatanga o te hypercalcemia o te mate kino, he whakapoauautanga o te mate ka taea te mate.Ko te Hypercalcemia o te mate kino ka puta ki runga ki te 50% o nga turoro kua tohua he mate pukupuku u matatau, myeloma maha, me te mate pukupuku pūtau iti iti.Ka puta mai tenei ahuatanga i te wa e puta mai ai nga matū matū e te puku ka kaha te whakaihiihi o nga osteoclast.Mena ka piki ake te whakahekenga o nga wheua, ka tukuna ano te konupūmā ki roto i te plasma.Ki te piki tere te kuhanga o te konupūmā i roto i te toto, ka kore e taea e nga whatukuhu te hapai i te taumahatanga, ka puta te hypercalcemia.Ko te waikawa Zoledronic he whakaheke i nga kohinga konupūmā plasma ma te aukati i te urunga o nga wheua (te aukati i te mahi osteoclastic me te whakauru o te apoptosis osteoclast).I tua atu, kua whakamanahia te waikawa zoledronic e te US FDA mo te maimoatanga o te myeloma maha me nga metastases wheua e pa ana ki nga mate pukupuku totoka-a-tumu (hei tauira, te piko me te huhu).