Zoledronic Acid CAS 118072-93-8 Purity ≥99.7% API Factory Kounga teitei
Whakarato me te Maama me te Kounga Pumau
Ingoa matū: Zoledronic Acid
CAS: 118072-93-8
He kaha te Farnesyl Diphosphate (FPP) Synthase Inhibitor
API Kounga Teitei, Hanganga Tauhokohoko
| Ingoa matū | Waikawa Zoledronic |
| Nga kupu taurite | ZOL 446, ZA, Zoledronate, CGP-4244, GP42446A, Zometa, Zomera;[1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene] waikawa bisphosphonic |
| Tau CAS | 118072-93-8 |
| Tau CAT | RF-API90 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C5H10N2O7P2 |
| Taumaha rāpoi | 272.09 |
| Iwi Whakarewa | 193.0~204.0 ℃ |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura Tioata-White |
| Tautuhinga | IR Spectrum o te tauira e rite ana ki tera o te paerewa tohutoro |
| pH | 2.0~4.0 |
| Wairewa | He iti te whakarewa i roto i te 0.1N Sodium Hydroxide Solution, He Iti Rere ki te Wai me te 0.1N Waiwai Putakawa, Tata Karekau i te Ewaro |
| Nga Taonga Paanga | |
| Te poke takitahi | ≤0.10% |
| Nga poke katoa | ≤0.30% |
| Ngaronga i te whakamaroke | 5.0%~7.0% |
| pūhaumāota | ≤0.02% |
| Phosphite | ≤0.50% |
| Phosphate | ≤0.50% |
| Nga Korewa Taamaha | ≤10ppm |
| Maamaa | ≥99.7% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | API, FPP Synthase Inhibitor, Hypercalcemia of malignancy (HCM) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te waikawa Zoledronic (CAS 118072-93-8) he kaha te aukati synthase bisphophonate farnesyl diphosphate (FPP) (IC50=20 nM).Ka aukati i te resorption o nga wheua i waenga i te osteoclast.Ka aukati ano i te tohu Ras me te tipu puku, me te whakaawe i te apoptosis i roto i nga pūtau mate pukupuku pancreatic.Ka huri i te whakawhitinga epithelial-mesenchymal me te aukati i te whakahoutanga o nga pūtau mate pukupuku u ma te whakakore i te NF-κB.Ko te waikawa Zoledronic i whakamanahia e te US FDA i te tau 2001 mo te maimoatanga o te hypercalcemia o te mate kino, he whakapoauautanga o te mate ka taea te mate.Ko te Hypercalcemia o te mate kino ka puta ki runga ki te 50% o nga turoro kua tohua he mate pukupuku u matatau, myeloma maha, me te mate pukupuku pūtau iti iti.Ka puta mai tenei ahuatanga i te wa e puta mai ai nga matū matū e te puku ka kaha te whakaihiihi o nga osteoclast.Mena ka piki ake te whakahekenga o nga wheua, ka tukuna ano te konupūmā ki roto i te plasma.Ki te piki tere te kuhanga o te konupūmā i roto i te toto, ka kore e taea e nga whatukuhu te hapai i te taumahatanga, ka puta te hypercalcemia.Ko te waikawa Zoledronic he whakaheke i nga kohinga konupūmā plasma ma te aukati i te urunga o nga wheua (te aukati i te mahi osteoclastic me te whakauru o te apoptosis osteoclast).I tua atu, kua whakamanahia te waikawa zoledronic e te US FDA mo te maimoatanga o te myeloma maha me nga metastases wheua e pa ana ki nga mate pukupuku totoka-a-tumu (hei tauira, te piko me te huhu).
