2-Methyltryptamine CAS 2731-06-8 Purità > 99.0% (HPLC) Panobinostat Fabbrika Intermedja ta 'Kwalità Għolja
Provvista tal-Manifattur Bi Kwalità Għolja, Produzzjoni Kummerċjali
Isem Kimiku: 2-Methyltryptamine CAS: 2731-06-8
Isem Kimiku | 2-Methyltryptamine |
Sinonimi | 2-Methylindole-3-Ethylamine;2-(2-Methyl-1H-indol-3-yl)ethanamine;3-(2-Aminoethyl)-2-Methylindole |
Numru CAS | 2731-06-8 |
Numru tal-KAT | RF-PI1480 |
Status tal-istokk | Fil-Ħażna, Skala ta' Produzzjoni Sa Tunnellati |
Formula Molekulari | C11H14N2 |
Piż Molekulari | 174.25 |
Punt tat-tidwib | 106.0 sa 110.0 ℃ |
Punt tat-togħlija | 177℃/1.5mmHg (mixgħul) |
Brand | Ruifu Kimika |
Oġġett | Speċifikazzjonijiet |
Dehra | Solidu Kannella |
Purità / Metodu ta 'Analiżi | >99.0% (Żona HPLC) |
1-HNMR | Konsistenti mal-Istruttura |
Telf fuq Tnixxif | <1.00% |
Impurità Unika | <0.50% |
Impuritajiet Totali | <1.00% |
Metalli tqal (bħala Pb) | <20ppm |
Standard tat-Test | Standard tal-Intrapriża |
Użu | Intermedji Farmaċewtiċi;Panobinostat Intermedju |
Pakkett: Flixkun, borża tal-fojl tal-aluminju, 25kg/Drum tal-Kartun, jew skont il-ħtieġa tal-klijent.
Kundizzjoni tal-Ħżin:Aħżen f'kontenituri ssiġillati f'post frisk u niexef;Ipproteġi mid-dawl u l-umdità.
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2-Methyltryptamine (CAS: 2731-06-8) huwa materjal tal-bidu ewlieni fis-sintesi ta 'Panobinostat (LBH589) (CAS: 404950-80-7).Panobinostat huwa inibitur qawwi tal-histone deacetylases (HDACs), b'valuri Ki li jvarjaw minn 0.6 sa 31 nM għal HDAC1-11.Permezz ta 'din l-azzjoni, twassal għal aċetilazzjoni ta' firxa ta 'proteini ċellulari, li tirriżulta f'arrest taċ-ċiklu taċ-ċelluli u apoptożi fiċ-ċelloli tal-kanċer.Panobinostat huwa l-ewwel inibitur HDAC li ġie approvat mill-FDA għat-trattament tal-majeloma multipla.Panobinostat jitqiegħed fis-suq bħala Farydak, jintuża flimkien ma' Bortezomib (CAS: 179324-69-7) u Dexamethasone (CAS: 50-02-2) biex jikkura majeloma multipla rikaduta wara kura preċedenti b'Bortezomib u immunomodulatur.
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