Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4 Purità > 98.0% (HPLC) Fabbrika Intermedja ta' Lenvatinib Mesylate
Ruifu Provvista Kimika Lenvatinib Mesylate Intermedji B'Purità Għolja
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Metil 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
4-Amino-2-Methoxybenzoate tal-metil CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Metil 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Isem Kimiku | Metil 4-Chloro-7-Methoxyquinoline-6-Carboxylate |
Sinonimi | Lenvatinib Impurità 47;4-Chloro-7-Methoxyquinoline-6-Carboxylic Acid Methyl Ester;4-Chloro-7-Methoxy-6-Quinolinecarboxylic Aċidu Methyl Ester;Lenvaint-D |
Numru CAS | 205448-66-4 |
Numru tal-KAT | RF-PI1970 |
Status tal-istokk | Fil-Ħażna, Skala ta' Produzzjoni Sa Tunnellati |
Formula Molekulari | C12H10ClNO3 |
Piż Molekulari | 251.67 |
Punt tat-togħlija | 377.4±37.0℃ |
Densità | 1.320±0.06 g/cm3 |
Brand | Ruifu Kimika |
Oġġett | Speċifikazzjonijiet |
Dehra | Trab Solidu Off-White għal Isfar |
Spettru 1H NMR | Konsistenti mal-Istruttura |
Purità / Metodu ta 'Analiżi | >98.0% (HPLC) |
Telf fuq Tnixxif | <1.00% |
Impuritajiet Totali | <2.00% |
Standard tat-Test | Standard tal-Intrapriża |
Użu | Intermedju/Impurità ta' Lenvatinib Mesylate (CAS: 857890-39-2) |
Pakkett: Flixkun, borża tal-fojl tal-aluminju, 25kg/Drum tal-Kartun, jew skont il-ħtieġa tal-klijent
Kundizzjoni tal-Ħżin:Aħżen f'kontenituri ssiġillati f'post frisk u niexef;Ipproteġi mid-dawl u l-umdità
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Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate (CAS: 205448-66-4) huwa intermedju ta 'Lenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib huwa mediċina tal-kanċer tat-tirojde żviluppata minn Eisai Corporation tal-Ġappun (Kodiċi: E7080), li tappartjeni għall-inibitur ta 'tirosine kinase orali multi-receptor (RTK) u jista' jinibixxi l-attività kinase tal-fattur tat-tkabbir endoteljali vaskulari Riċetturi R1 (FLT1), VEG-FR2 (KDR), R3 (FLT4).Lenvatinib jista 'wkoll jinibixxi l-involviment ta' RTKs oħra f'anġjoġenesi patoloġika, tkabbir tat-tumur, u progressjoni tal-kanċer ħlief għall-funzjonijiet ċellulari normali tagħhom inklużi riċetturi tal-fattur tat-tkabbir tal-fibroblast (FGF) FGFR1, 2, 3, u 4;riċettur tal-fattur tat-tkabbir derivat mill-plejtlits (PDGFR [alpha]), KIT, u RET.[Indikazzjonijiet]: Lenvatinib huwa adattat għat-trattament ta 'pazjenti ta' kanċer tat-tirojde ta 'rikorrenza lokali jew tip ta' metastasi, tip ta 'progressività u tip differenzjat refrattarju għall-jodju radjuattiv.
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