N-Cbz-L-Valine CAS 1149-26-4 Z-Val-OH Purity >99.0% (HPLC) Factory

N-Cbz-L-Valine (Z-Val-OH) (CAS: 1149-26-4) is an N-Cbz-protected form of L-Valine. N-Cbz-L-Valine is a valine protected by Cbz and is widely used in the field of drug synthesis. L-Valine is an essential amino acid that is used as an ingredient in cosmetic formulations, pharmaceuticals, and animal feed products. L-Valine is also important for growth and ammonia detoxification in humans.
Z-Amino Acid, can be used in peptide synthesis, can be also used as an organic synthesis intermediate, pharmaceutical intermediate, biochemical reagent or chemical reagent.
N-Cbz-L-Valine can be used in the manufacturing of API's like Imatinib, Valaciclovir.
Preparation take 1.17Kg (10mol) of L-Valine, 5L of 2mol/L sodium hydroxide solution and 1.06Kg (10mol) of sodium carbonate into a 20L reaction kettle, start stirring, after L-Valine is completely dissolved, reduce the temperature of the solution to below 0℃, and drip 1 containing 2.05Kg(12mol) of benzyl chloroformate, 4-dioxane solution 5L, the temperature of the solution in the dropping process is kept below 20℃, after dropping, the reaction is 8h at room temperature. At the end of the reaction, the reaction liquid is extracted with dichloromethane 2.5L, the organic phase is discarded, the aqueous phase is cooled to below 10℃, concentrated hydrochloric acid is dropped until pH=2, then stirred at 10℃ for 30min, a large amount of white solid is precipitated, filtration is carried out, the filter residue is washed with water, the white solid is put into a vacuum drying oven to dry, and the yield is 93.7%.