N-Fluorobenzenesulfonimide (NFSI) CAS 133745-75-2 Purity >98.0% (HPLC) Fluorinating Reagent

N-Fluorobenzenesulfonimide (NFSI) (CAS: 133745-75-2), Versatile fluorinating reagent used in the fluorination of aryls, enolates, carbanions, organolithiums, etc.
N-Fluorobenzenesulfonimide is a commonly used electrophilic fluorinating agent in organic synthesis to introduce fluorine into neutral organic molecules. It is also used to fluorinate nucleophilic substrates such as reactive organometallic species and malonate anions. NFSi can be synthesized by the reaction of benzenesulfonimide with fluorine.
N-Fluorobenzenesulfonimide is a new, stable and mild fluorination reagent, which can introduce fluo rine atoms into the carbonyl ortho position of organic molecules, and can perform monofluorination reaction on electron-rich aromatic compounds, enol sila ne, ene Chemicalbook alcohol lithium salt, etc. The current research hotspots include Nazarov cyclization reaction catalyzed by iron or cobalt to form five-membered ring, and asymmetric catalysis of enantioselective α-fluorination.
N-Fluorobenzenesulfonimide fluorinates aromatics, enolates, azaenolates and carbanions in high yield. It is used for diastereoselective fluorination of Li enolates of chiral carboximides, for directed fluorination of ortho-lithiated aromatics and for a review of electrophilic N-F fluorinating agents. Asymmteric fluorinations is effected in the presence of a Pd-BINAP catalyst system at room temperature in an ionic liquid. It is a reagent employed in a palladium-catalyzed enantioselective fluorination of t-butoxycarbonyl lactones and lactams. It is also used in the electrophilic difluorination of dihalopyridines with butyl lithium and in the direct conversion of alcohols to dibenzenesulfonamides with triphenylphosphine.