2,3-Dihydrobenzofuran CAS 496-16-2 Ramelteon Intermediate Purity>99.0% (GC)

2,3-Dihydrobenzofuran (CAS: 496-16-2) imagwiritsidwa ntchito kwambiri popanga mankhwala a tricyclic komanso ndizinthu zapakatikati zopangira mankhwala ofunikira.2,3-Dihydrobenzofuran ingagwiritsidwe ntchito ngati pakati pa Ramelteon (CAS: 196597-26-9).Ramelteon, wogulitsidwa ngati Rozerem ndi Takeda Pharmaceuticals North America, ndi wothandizira kugona omwe amamangiriza MT1 ndi MT2 receptors mu suprachiasmatic nucleus (SCN), m'malo momangirira ku GABAA receptors, monga mankhwala monga zolpidem.Komabe sizikuwoneka kuti zikufulumizitsa kuyamba kwa tulo kapena kuchuluka kwa kugona komwe munthu amapeza.Imavomerezedwa ndi US Food and Drug Administration (FDA) kuti igwiritsidwe ntchito kwa nthawi yayitali.Ramelteon samasonyeza kuyamikira kulikonse kwa GABAA receptors, zomwe zimagwirizanitsidwa ndi anxiolytic, myorelaxant, ndi amnesic zotsatira.Mosiyana ndi mankhwala ambiri a kusowa tulo omwe amakhudza GABA (g-aminobutyric acid) receptor complex, ramelteon ndi agonist wa melatonin receptor.Makamaka, ili ndi kusankha kwakukulu kwa ma subtypes a MT1 ndi MT2, omwe adakhudzidwa ndi kusungitsa ma circadian rhythms, pa cholandirira cha MT3 chomwe chimayang'anira ntchito zina za melatonin.2,3-Dihydrobenzofuran imagwiritsidwanso ntchito popanga antitumor agents benzofuran sulfonylureas, HIV protease inhibitor amino acid hydroxyethylenesulfonyl, matrix metalloproteinase inhibitor aryl sulfinyl isoxime hydroxamic acid, etc.