2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5 Remdesivir Yapakatikati COVID-19
Opanga Zogulitsa Zamalonda Remdesivir ndi Othandizira Ofananira Ndi Ubwino Wapamwamba
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Dzina la Chemical | 2,3,5-Tri-O-benzyl-D-ribonolactone |
Mawu ofanana ndi mawu | 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone;Remdesivir Intermediate |
Nambala ya CAS | 55094-52-5 |
Nambala ya CAT | RF-PI301 |
Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
Molecular Formula | C26H26O5 |
Kulemera kwa Maselo | 418.49 |
Melting Point | 54.0-55.0 ℃ |
Mkhalidwe Wosungira | Kutentha kwa Chipinda |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Yellowish kapena White Olimba |
Kusungunuka | Kusungunuka mu CH2Cl2 ndi Insoluble mu H2O |
NMR ndi MS | Muyenera Kutsatira |
Chizindikiritso | IR ndi TLC |
Chinyezi | ≤1.0% |
Zotsalira pa Ignition | ≤0.50% |
Chidetso Chilichonse Chamunthu | ≤0.50% |
Zitsulo Zolemera | ≤50ppm |
HPLC (210nm) | ≥99.0% |
HPLC (ELSD) | ≥99.0% |
Test Standard | Enterprise Standard |
Kugwiritsa ntchito | Wapakatikati wa Remdesivir (CAS 1809249-37-3) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
2,3,5-Tri-O-benzyl-D-ribonolactone (CAS 55094-52-5) ndi Remdesivir wapakatikati.Remdesivir (CAS 1809249-37-3) ndi mankhwala osokoneza bongo m'gulu la nucleotide analogs, omwe amagwiritsidwa ntchito pochiza COVID-19.Remdesivir (GS-5734) ndi buku la antiviral nucleoside analogue lomwe limaletsa murine hepatitis virus (MHV) yokhala ndi EC50 yofanana ndi SARS-CoV ndi MERS-CoV.Coronaviruses (CoVs) ndi ma virus a RNA okhala ndi chingwe chimodzi omwe amapatsira nyama zambiri.Mwa anthu, ma CoVs adadziwika kuti nthawi zambiri amayambitsa chimfine ndi chibayo mpaka kutuluka kwa acute kupuma kwapang'onopang'ono coronavirus (SARS-CoV) mu 2002 ndi Middle East Respiratory Syndrome (MERS-CoV) mu 2012 kuchokera ku zoonotic magwero.Remdesivir ndi monophosphoramidate prodrug wa C-adenosine nucleoside analogue GS-441524.M'maselo ochedwa chotupa muubongo (DBT) omwe ali ndi MHV, GS-5734 inaletsa MHV mwamphamvu kuposa GS-441524, yokhala ndi GS-5734 EC50 ya 0.03 M. Komanso, mfundo za EC50 zidatsimikiziridwa pambuyo pochiza GS-441524 ndi GS-5734 ndi GS-5734. mu zikhalidwe za SARS-CoV- ndi MERS-CoV-infected primary human airway epithelial cell (HAE).