3--[3-(Trifluoromethyl)phenyl] -1-Propanol CAS 78573-45-2 Cinacalcet Hydrochloride Intermediate Purity>99.0% (HPLC)

3--[3- (Trifluoromethyl) phenyl] -1-Propanol (CAS: 78573-45-2) ndi yapakatikati mwa kaphatikizidwe ka Cinacalcet Hydrochloride (CAS: 364782-34-3).Cinacalcet ndiye kulowa koyamba mu kalasi yatsopano yamankhwala otchedwa calcimimetics.Idayambitsidwa ngati chithandizo chapakamwa cha sekondale hyperparathyroidism (SHPT) kwa odwala omwe ali ndi matenda a impso osatha pa dialysis komanso hypercalcemia mwa odwala omwe ali ndi parathyroid carcinoma.SHPT imagwirizanitsidwa ndi kuwonjezeka kwa hormone ya parathyroid (PTH), yomwe imayambitsidwa ndi kuchepa kwa calcium mu seramu chifukwa cha kulephera kwa impso kuchotsa phosphorous kuchokera m'thupi komanso kulephera kupanga mavitamini D okwanira. Zotsatira za kuwonjezeka kwa PTH Zimaphatikizapo kukondoweza kwa osteoclastic ntchito, cortical bone resorption ndi marrow fibrosis.Kutsekemera kwa PTH kumayendetsedwa makamaka ndi calcium-sensing receptor (CaR), yomwe ili pamwamba pa selo lalikulu la parathyroid gland.Calcimimetics imamangiriza ku CaR ndikuwonjezera kukhudzika kwa CaR ku calcium ya extracellular, motero imachititsa kuti iyambe kugwira ntchito pamlingo wocheperako wa seramu calcium.Zotsatira zake, pamaso pa othandizira awa, kuchepa kwa calcium yamkati mwa odwala omwe ali ndi vuto laimpso amatha kukhala ndi mphamvu yopondereza pakutulutsa kwa PTH.Parathyroid carcinoma imalumikizidwanso ndi kuchuluka kwa PTH, komwe kumayendetsedwa ndi ntchito yodziyimira payokha ya parathyroid gland ndipo kenako imayambitsa hypercalcemia.Ngakhale kuti opaleshoni ndiyo njira yoyamba yothandizira odwala matenda a hypercalcemia mwa odwala a parathyroid carcinoma, calcimimetics imapereka njira ina yopanda opaleshoni kwa odwala omwe ali ndi vuto la parathyroidectomy, metastatic parathyroid carcinoma, kapena chiopsezo chachikulu cha opaleshoni.