4-Amino-3-Chlorophenol CAS 17609-80-2 Lenvatinib Mesylate Intermediate Purity>99.0% (HPLC)

4-Amino-3-Chlorophenol (CAS: 17609-80-2) ndi mankhwala ofunikira kwambiri apakati, omwe amagwiritsidwa ntchito kwambiri popanga ndi kaphatikizidwe ka anti-chotupa, matenda a mtima, matenda a ubongo.4-Amino-3-Chlorophenol ndizofunikira zapakatikati pokonzekera Lenvatinib Mesylate (CAS: 857890-39-2).Yopangidwa ndi Eisai Inc., lenvatinib mesylate ndi vascular endothelial growth factor receptor (VEGF) inhibitor yomwe imakhala ndi zochita zotsutsana ndi VEGF subtypes 1, 2, ndi 3 ndipo idavomerezedwa ndi FDA mu 2015 kuchiza khansa ya chithokomiro yosiyana yomwe imapezeka kwanuko. mobwerezabwereza, metastatic, kapena kupita patsogolo ndipo sanayankhe chithandizo cha radioactive ayodini.Mu Meyi 2016, a FDA adavomereza mankhwalawa ngati mankhwala ophatikizika ndi everolimus pochiza matenda a renal cell carcinoma.Chifukwa chakuti VEGF (ndi fibroblast growth factor receptors, yotchedwa FGFRs) imaganiziridwa kuti imakhala ndi gawo la njira zowonetsera mtima, VEGF2R ndi FGFR zoletsa zimaganiziridwa kuti ndizo njira zomwe zimayambitsa zotsatira za lenvatinib mesylate, zomwe ndi matenda oopsa.