4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Purity>99.0% (HPLC) Aprepitant Intermediate Factory
Wopanga wamkulu ndi wogulitsa
Pakati pa Aprepitant (CAS: 170729-80-3)
4-Benzyl-2-Hydroxymorpholin-3-imodzi CAS 287930-73-8
(R) -1- [3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 4-Benzyl-2-Hydroxymorpholin-3-imodzi |
| Mawu ofanana ndi mawu | 4-Benzyl-2-Hydroxy-Morpholin-3-imodzi;2-Hydroxy-4- (Phenylmethyl) -3-Morpholinone;Chidetso cha Aprepitant 48;Chidetso cha Fosaprepitant 23;Aprepitant Intermediate Ⅱ |
| Nambala ya CAS | 287930-73-8 |
| Nambala ya CAT | Mtengo wa RF2660 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C11H13NO3 |
| Kulemera kwa Maselo | 207.23 |
| Melting Point | 134.0 mpaka 138.0 ℃ |
| Boiling Point | 441.7±45.0℃ |
| Kuchulukana | 1.292±0.06 g/cm3 |
| Kusungunuka mu Madzi | DMSO (Pang'ono), Methanol (Pang'ono, Kutentha) |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera mpaka Woyera wa Crystal |
| Kuyera / Kusanthula Njira | >99.0% (HPLC) |
| Melting Point | 134.0 mpaka 138.0 ℃ |
| Madzi (wolemba Karl Fischer) | <0.50% |
| Zotsalira pa Ignition | <0.20% |
| Zonse Zonyansa | <1.00% |
| Proton NMR Spectrum | Zimagwirizana ndi Kapangidwe |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Pakati pa Aprepitant (CAS: 170729-80-3) Antiemetic Drug |
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4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), ndi yapakatikati ya Aprepitant (CAS: 170729-80-3), yogwiritsidwa ntchito ngati mankhwala oletsa antiemetic.Aprepitant ndi neurokinin-1 (NK-1) receptor antagonist ndipo ndi wa othandizira kusanza panthawi ya chemotherapy ya khansa.Choyamba chinapangidwa bwino ndi Merck Company (Germany).Mu Marichi 2003, US Food and Drug Administration idavomereza kuti izigwiritsidwa ntchito pochiza kusanza kwa chemotherapy.Chogulitsachi chimakhala ndi chiyanjano chosankha kwambiri kwa anthu pomwe chimakhala chochepa kwambiri ndi serotonin, dopamine ndi glucocorticoid receptor affinity.Aprepitant, pamene ikuphatikizidwa ndi 5-HT3 receptor inhibitors (monga ondansetron hydrochloride) ndi corticosteroid dexamethasone, imatha kuchepetsa kwambiri cisplatin-induced acute and (kapena) kuchedwa emesis.Kugwiritsa ntchito mankhwalawa kokha kungakhale ndi zotsatira zodzitetezera.
![(R) -1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2 Purity> 99.0% (GC) Aprepitant Intermediate](https://www.ruifuchemical.com/uploads/R-1-35-Bistrifluoromethylphenylethanol-CAS-127852-28-2-300x300.jpg)