5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Supply Vonoprazan Fumarate ndi Related Intermediate
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Dzina la Chemical | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| Mawu ofanana ndi mawu | Vonoprazan Fumarate (TAK-438) Yapakatikati 3 |
| Nambala ya CAS | 881674-56-2 |
| Nambala ya CAT | RF-PI330 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C11H8FNO |
| Kulemera kwa Maselo | 189.19 |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Yellow mpaka Brown Powder |
| Melting Point | 122.0 ~ 131.0 ℃ |
| Chizindikiritso: RT(HPLC) | Tsatirani ndi Reference Standard |
| Kutaya Pa Kuyanika | ≤0.50% |
| Zotsalira Pa Ignition | ≤0.50% |
| Zogwirizana nazo | |
| Chiyero | ≥99.0% |
| Chidetso Chilichonse Chilichonse | ≤0.50% |
| Zonse Zonyansa | ≤1.0% |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Pakati pa Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani m'mitsuko yosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
5-(2-Fluorophenyl) -1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) imagwira ntchito ngati reagent pakupanga kokonzekera kwa zolemba za pyrrole monga potaziyamu-competitive acid blocker (P-CAB).5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde ndi yapakatikati ya Vonoprazan Fumarate (CAS 1260141-27-2).Vonoprazan fumarate (Takecab®), yomwe idapezeka ndikupangidwa ndi Takeda ndi Otsuka, idavomerezedwa ndi PMDA yaku Japan mu Disembala 2014, ndipo imawonetsedwa pochiza zilonda zam'mimba, zilonda zam'mimba ndi reflux esophagitis.Vonoprazan fumarate ali ndi buku limagwirira zochita otchedwa potaziyamu-mpikisano asidi blockers, amene mpikisano ziletsa kumanga ayoni potaziyamu H+, K+ -ATPase (amatchedwanso pulotoni mpope) mu sitepe yomaliza ya chapamimba asidi katulutsidwe mu chapamimba parietal maselo.Vonoprazan saletsa Na+, K+ -ATPase ntchito ngakhale pa ndende nthawi 500 kuposa IC50 makhalidwe awo motsutsana chapamimba H+, K+ -ATPase ntchito.Komanso, mankhwalawa sakhudzidwa ndi chapamimba secretory state, mosiyana ndi PPIs.
