5-Fluorocytosine (5-FC) CAS 2022-85-7 Purity ≥99.5% (HPLC) Capecitabine Emtricitabine Intermediate Factory

5-Fluorocytosine (5-FC) CAS: 2022-85-7 Njira Yowunikira
Maonekedwe-Woyera Kapena Ufa Woyera Wamakristalo
Kutaya pa Kuyanika-Kuwumitsa pa 105 kwa maola 4: sikutaya kuposa 1.50% ya kulemera kwake.
Zotsalira pa Ignition - osapitirira 0.1%.
Heavy Metals - osapitirira 0.002%.
Fluoride-Sakanizani 70 mL ya potassium chloride solution yomwe yangokonzedwa kumene ndi 30 ml ya mowa wa isopropyl, mudzaze ma elekitirodi ndi mphamvu yamphamvu kwambiri, ndikulola kuti elekitirodi ikhalebe mu osakaniza kwa maola osachepera awiri musanagwiritse ntchito, kapena makamaka usiku wonse.
Mukatenga miyeso, tumizani yankho ku beaker ya 150-mL, ndikumiza maelekitirodi.Ikani chovundikira chokhala ndi politef mu beaker, ikani beaker pa chipwirikiti maginito chokhala ndi insulated pamwamba, ndi kulola kusonkhezera mpaka mgwirizano utatha (pafupifupi mphindi imodzi kapena ziwiri).Muzimutsuka ndi kupukuta maelekitirodi pakati pa miyeso, kusamala kuti musakanda kristalo mu electrode ya ayoni.
Yezerani kuthekera kwa kukonzekera kwa Mulingo uliwonse, ndikukonza kuchuluka kwa fluoride, mu mg pa 100 mL, motsutsana ndi kuthekera, mu mV, papepala la semilogarithmic.Yezerani kuthekera kwa kukonzekera Mayeso, ndikuzindikira kuchokera pamapindikira okhazikika a fluoride, mu mg pa 100 ml.Werengani kuchuluka kwa fluoride mu gawo la Flucytosine yotengedwa ndi formula:
C / 10
momwe C ndi kuchuluka kwa fluoride, mu mg pa 100 mL, kuchokera pamapindikira okhazikika: osapitilira 0.05% ya fluoride amapezeka.
Fluorouracil-Sungani 250 mg mu 10 ml ya osakaniza a glacial acetic acid ndi madzi (4: 1).Ikani 20 µL ya yankho ili pa mbale yopyapyala ya chromatographic yokutidwa ndi 0.5-mm wosanjikiza wa chromatographic silika gel osakaniza.Pambale yomweyi ikani 20 µL, mu 10-µL increments, ya 0.025 mg pa ml yankho la USP Fluorouracil RS mu osakaniza a glacial acetic acid ndi madzi (4: 1).Pangani chromatogram mu chisakanizo cha chloroform ndi glacial acetic acid (13: 7) mpaka zosungunulira kutsogolo kwasuntha osachepera 14 cm kuchokera pachiyambi.Chotsani mbale kuchokera m'chipinda chotukuka, ndipo lolani kuti zosungunulira zisungunuke.Pezani mawanga pa mbale poyang'ana pansi pa ma radiation afupiafupi a UV: malo aliwonse omwe amachokera ku yankho lomwe akuyesedwa sali aakulu mu kukula ndi mphamvu kuposa malo omwe ali pa RF yopangidwa ndi Standard solution, yofanana ndi yosapitirira 0.1% ya mankhwala fluorouracil.
Assay-Place pafupifupi 400 mg ya Flucytosine, yoyezedwa molondola, mu beaker ya 250-mL, onjezerani 150 mL ya osakaniza 2 voliyumu ya glacial acetic acid ndi 1 voliyumu ya acetic anhydride, ndi kusungunula, kutentha pang'ono ngati kuli kofunikira.Titrate potentiometrically ndi 0.1 N perchloric acid VS, pogwiritsa ntchito makina opangira magalasi a calomel-electrode.Chitani chitsimikiziro chopanda kanthu, ndipo pangani kukonza kulikonse kofunikira.ML iliyonse ya 0.1 N perchloric acid ndi yofanana ndi 12.91 mg ya C4H4FN3O.Flucytosine lili osachepera 98,5 peresenti osati oposa 101.0 peresenti ya C4H4FN3O, masamu pa zouma maziko.