5-Methylisoxazole-4-Carboxylic Acid CAS 42831-50-5 Leflunomide Intermediate Purity>99.0% (HPLC)

5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) ndi yapakatikati ya kaphatikizidwe ka Leflunomide (CAS: 75706-12-6).Leflunomide ndi mtundu wa isoxazole immunosuppressive mankhwala ndi odana proliferative ntchito, masiku pharmacology m'gulu mankhwala antipyretic, analgesic ndi odana ndi kutupa.Izi mankhwala akhoza mofulumira kutembenukira kwa yogwira metabolites ndi ntchito ndi chiwindi ndi matumbo cytoplasm ndi ma microsomes, ake;chachikulu limagwirira ndi pa DNA kaphatikizidwe, kuletsa kiyi enzyme-DHODH (DHODH) ntchito, kotero kuti ma nucleotides mkati B lymphocyte zatha, izo zimathetsa biosynthesis wa DNA ndi RNA, maselo sangathe kulowa s gawo, ndipo pamapeto pake sangathe. kuchulukirachulukira, zomwe zimabweretsa zotsatira zotsutsa-rheumatic, ndizoyenera kuchiza akuluakulu omwe ali ndi nyamakazi yogwira, ankylosing spondylitis, imatha kuchedwetsa kuwonongeka kwa mafupa, kuchepetsa zizindikiro ndi zizindikiro.Kuphatikiza apo, leflunomide imathanso kulepheretsa ntchito ya tyrosine kinase, potero kulepheretsa kuchuluka kwa T cell, B cell ndi maselo omwe alibe chitetezo chamthupi, komanso, ndi biosynthesis inhibition ya cyclooxygenase-2 (COX2), kuletsa kaphatikizidwe ka prostaglandin ndikuchita zotsutsa- zotsatira zotupa ndikuletsa ma mast cell ndi basophils histamine kumasulidwa.Mankhwalawa akagwiritsidwa ntchito poika odwala, kusintha kwa mlingo kumakhala kovuta, kumagwiritsidwa ntchito makamaka pochiza nyamakazi ya nyamakazi ndi matenda ena omwe amachititsa kuti thupi liziyenda bwino.