7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Purity>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Kufotokozera Kwachidule:

Dzina: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

CAS: 53449-14-2

Kuyera: > 99.0% (HPLC)

Maonekedwe: Ufa Wachikasu Wopepuka mpaka Wabulauni

Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Kufotokozera:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineChithunzi cha CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Dzina la Chemical	7-Chloro-6-Nitro-4-Hydroxyquinazoline
Mawu ofanana ndi mawu	7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4(3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-imodzi;7-Chloro-6-Nitroquinazolin-4(3H) -imodzi
Nambala ya CAS	53449-14-2
Nambala ya CAT	RF-PI2030
Stock Status	Mu Stock, Kupanga Kukula Mpaka Matani
Molecular Formula	C8H4ClN3O3
Kulemera kwa Maselo	225.59
Kumverera	Kutentha Kwambiri
Kusungunuka	Zosungunuka pang'ono mu Dimethylformamide
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Wachikasu Wopepuka mpaka Wabulauni
Chizindikiritso (HPLC)	Nthawi Yosungira Zitsanzo Iyenera Kufanana ndi Mulingo
Kuyera / Kusanthula Njira	>99.0% (HPLC)
Melting Point	300.0 ~ 303.0 ℃
M'madzi (KF)	<0.50%
Zotsalira pa Ignition	<0.30%
Chidetso 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
Chidetso 2	<0.50% (5,7-Dichloro-4[1H]quinazolinone)
Chidetso 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Chidetso China Chimodzi	<0.20%
Zonse Zonyansa	<1.00%
Zitsulo Zolemera (monga Pb)	<20ppm
Infrared Spectrum	Zimagwirizana ndi Kapangidwe
Proton NMR Spectrum	Proton NMR Spectrum
Test Standard	Enterprise Standard
Kugwiritsa ntchito	Pakati pa Afatinib, Afatinib Dimaleate

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi

Ubwino:

FAQ:

Ntchito:

7-Chloro-6-Nitro-4-Hydroxyquinazoline (CAS: 53449-14-2) ndi yapakatikati ya Afatinib Dimaleate (CAS: 850140-73-7).Afatinib ndi gulu losasinthika la ErbB la ma blockers omwe amapondereza kufalitsa zidziwitso ndikutsekereza njira zazikulu zomwe zimakhudzidwa ndi kukula kwa ma cell a khansa ndi magawano.Chifukwa njira yosinthira chidziwitso cha banja la ErbB imatha kuyambitsidwa ndi ma homodimers angapo ndi ma heterodimers, kuletsa munthawi imodzi kwa mamembala angapo a m'banja la ErbB (monga EGFR, HER2, ErbB3 ndi ErbB4) kumatha kusokoneza kutsitsa kwachidziwitso chakutsika.Afatinib amagwiritsidwa ntchito pochiza mtundu wina wa khansa ya m'mapapo (khansa ya m'mapapo yosakhala yaing'ono) yomwe yafalikira ku ziwalo zina za thupi.Ndi m'gulu la mankhwala omwe amadziwika kuti kinase inhibitors.Zimagwira ntchito pochepetsa kapena kuletsa kukula kwa maselo a khansa.Imamangiriza ku puloteni inayake (epidermal receptor-EGFR) mu zotupa zina.