7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3 Purity>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Kufotokozera Kwachidule:

Dzina la Mankhwala: 7-Fluoro-6-Nitroquinazolin-4 (1H) -imodzi

CAS: 162012-69-3

Kuyera: > 99.0% (HPLC)

Yellow to Reddish Yellow Crystal kapena Ufa

Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Ubwino Wapamwamba, Kupanga Zamalonda

E-Mail: alvin@ruifuchem.com

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Kufotokozera:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineChithunzi cha CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Dzina la Chemical	7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi
Mawu ofanana ndi mawu	7-Fluoro-6-Nitroquinazolin-4 (3H) -imodzi;7-Fluoro-4-Hydroxy-6-Nitroquinazoline;7-Fluoro-6-Nitroquinazolin-4-ol;7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-imodzi
Nambala ya CAS	162012-69-3
Nambala ya CAT	RF-PI2025
Stock Status	Mu Stock, Kupanga Kukula Mpaka Matani
Molecular Formula	C8H4FN3O3
Kulemera kwa Maselo	209.13
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Yellow to Reddish Yellow Crystal kapena Ufa
1 H NMR Spectrum	Zogwirizana ndi Kapangidwe
Kuyera / Kusanthula Njira	>99.0% (HPLC)
Kutaya pa Kuyanika	<0.50%
Zonse Zonyansa	<1.00%
Proton NMR Spectrum	Zimagwirizana ndi Kapangidwe
Test Standard	Enterprise Standard
Kugwiritsa ntchito	Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi

Ubwino:

FAQ:

Ntchito:

7-Fluoro-6-Nitroquinazolin-4 (1H)-imodzi (CAS: 162012-69-3) ndi yapakatikati ya Afatinib Dimaleate (CAS: 850140-73-7).Afatinib ndi gulu losasinthika la ErbB la ma blockers omwe amapondereza kufalitsa zidziwitso ndikutsekereza njira zazikulu zomwe zimakhudzidwa ndi kukula kwa ma cell a khansa ndi magawano.Chifukwa njira yosinthira chidziwitso cha banja la ErbB imatha kuyambitsidwa ndi ma homodimers angapo ndi ma heterodimers, kuletsa munthawi imodzi kwa mamembala angapo a m'banja la ErbB (monga EGFR, HER2, ErbB3 ndi ErbB4) kumatha kusokoneza kutsitsa kwachidziwitso chakutsika.Afatinib ndi mankhwala ovomerezeka kuti azichiza omwe si aang'ono cell lung carcinoma(NSCLC), opangidwa ndi Boehringer Ingelheim.Amagwira ntchito ngati angiokinase inhibitor.Monga lapatinib ndi neratinib, afatinib ndi tyrosine kinase inhibitor (TKI) yomwe imalepheretsanso munthu kutulutsa epidermal growth factor receptor 2 (Her2) ndi epidermal growth factor receptor (EGFR) kinases.Afatinib samangogwira ntchito motsutsana ndi kusintha kwa EGFR komwe kumayang'aniridwa ndi m'badwo woyamba wa TKIs likeerlotinib kapena gefitinib, komanso motsutsana ndi omwe samakhudzidwa ndi mankhwalawa.Chifukwa cha ntchito yake yowonjezera yolimbana ndi Her2, ikufufuzidwa za khansa ya m'mawere komanso khansa zina zoyendetsedwa ndi EGFR ndi Her2.