Acesulfame K CAS 55589-62-3 Acesulfame Potassium Purity>99.0% (HPLC)

TANTHAUZO
Acesulfame Potassium ili ndi NLT 99.0% ndi NMT 101.0% ya C4H4NO4SK, yowerengedwa pa zouma.
CHIZINDIKIRO
• A. KUYAMBIRA KWA INFRARED <197K>
• B. KUYESA KUDZIWA KWAMBIRI, Potaziyamu <191>
Yankho lachitsanzo: 100 mg/mL
Njira zolandirira: Imakwaniritsa zofunikira
ZOYESA
• NTCHITO
Chitsanzo: 150 mg
Titrimetric system (Onani Titrimetry <541>)
Mode: Direct titration
Titrant: 0.1 N perchloric acid VS
Chopanda kanthu: 50 ml ya glacial acetic acid
Kuzindikira komaliza: Potentiometric
Kusanthula: Sungunulani Chitsanzo mu 50 ml ya glacial acetic acid.
Titrate ndi 0.1 N perchloric acid VS.Chitani chitsimikiziro chopanda kanthu.
Werengani kuchuluka kwa potaziyamu acesulfame (C4H4NO4SK) mu Zitsanzo:
Zotsatira = [(V − B) × N × F × 100]/W
V = kuchuluka kwa titrant kudyedwa ndi Zitsanzo (mL)
B = kuchuluka kwa titrant kudyedwa ndi Chopanda kanthu (mL)
N = chizolowezi chenicheni (mEq/mL)
F = chinthu chofanana, 201.2 mg/mEq
W = kulemera kwa Zitsanzo (mg)
Njira zolandirira: 99.0% -101.0% pazowuma
ZOCHITSA
• MALIRE A FLUORIDE
[Dziwani-Gwiritsani ntchito zinthu zapulasitiki poyeserera uku.]
Yankho A: Sungunulani 210 g wa citric acid monohydrate mu 400 mL madzi.Sinthani ndi ammonia yokhazikika kukhala pH ya 7.0, ndikuchepetsa ndi madzi mpaka 1000 mL.
Yankho B: 132 mg/mL ya dibasic ammonium phosphate
Yankho C: Pa kuyimitsidwa kwa 292 g wa edetic acid mu 500 ml ya madzi, onjezerani 200 mL ya ammonium hydroxide, sinthani ndi ammonium hydroxide kukhala pH pakati pa 6 ndi 7, ndi kusungunula ndi madzi kupanga 1000 mL.
Yankho la buffer: Sakanizani ma voliyumu ofanana a Solution A, Solution B ndi Solution C, ndikusintha ndi ammonium hydroxide kukhala pH ya 7.5.
Kulemera kwa 0.442 g ya sodium fluoride, yowumitsidwa kale pa 300 ° kwa maola 12, mu botolo la 1-L la volumetric, ndi kusungunula ndi madzi mpaka voliyumu.Sungani yankho mu chidebe cha pulasitiki chotsekedwa.Musanagwiritse ntchito, pipet 5 ml ya yankho ili mu botolo la voliyumu ya 100-mL, ndi kusungunula ndi madzi mpaka voliyumu.Iliyonse ya ml ya yankho ili ndi 10µg ya ayoni wa fluoride.
Yankho lokhazikika A: Sakanizani 0.5 mL ya Standard stock solution ndi 15.0 mL ya Buffer solution, ndi kusungunula ndi madzi mpaka 50mL.
Njira yokhazikika B: Sakanizani 1.0 mL ya Standard stock solution ndi 15.0 mL ya Buffer solution, ndi kusungunula ndi madzi mpaka 50mL.
Yankho lokhazikika C: Sakanizani 1.5 mL ya Standard stock solution ndi 15.0 mL ya Buffer solution, ndi kusungunula ndi madzi mpaka 50mL.
Njira yokhazikika D: Sakanizani 3.0 mL ya Standard stock solution ndi 15.0 mL ya Buffer solution, ndi kusungunula ndi madzi kufika pa 50mL.
Yankho lachitsanzo: Ku botolo la volumetric 50-mL onjezerani 3 g wa Acesulfame Potassium.Sungunulani m'madzi, onjezerani 15.0 mL ya Buffer solution, ndi kusungunula ndi madzi mpaka kuchuluka.
Kusanthula
Zitsanzo: Yankho lokhazikika A, yankho lokhazikika B, yankho lokhazikika C, yankho lokhazikika D, ndi yankho lachitsanzo
Yezerani nthawi yomweyo kuthekera (onani Titrimetry <541>) mu mV, ya Standard solutions ndi Sample solution, yokhala ndi pH mita yoyenera yokhala ndi electrode yodziwika ndi fluoride ndi elekitirodi ya silver-silver chloride.Mukatenga miyeso, tumizani yankho ku beaker ya 25-mL, ndikumiza maelekitirodi.Ikani chovundikira chokhala ndi politef mu beaker, ikani beaker pa choyatsira maginito chokhala ndi zotchinga pamwamba ndikulola kugwedezeka mpaka mgwirizano utakhazikika (1-2 min).Muzimutsuka, ndi kupukuta maelekitirodi pakati pa miyeso, kusamala kuti musakanda krustalo mu electrode yokhudzana ndi fluoride.Yezerani kuthekera kwa yankho lililonse la Mulingo, ndikukonza kuchuluka kwa fluoride, mu µg/mL, motsutsana ndi kuthekera, mu mV, papepala la semilogarithmic.Yezerani kuthekera kwa yankho la Zitsanzo, ndikuzindikira kuchuluka kwa fluoride kuchokera pamapindikira okhazikika, mu µg/mL.
Kuwerengera zomwe zili, mu ppm, za fluoride mu gawo la Acesulfame Potassium lomwe latengedwa:
Zotsatira = (V × C/W)
V = kuchuluka kwa Sample solution (mL)
C = kuchuluka kwa fluoride mu Sample solution, kuchokera pamapindikira okhazikika (mg/mL)
W = kulemera kwa Acesulfame Potassium wotengedwa kukonzekera Sample solution (g)
Njira zolandirira: NMT 3 ppm
• ZINTHU ZONSE, Njira I <231>: NMT 10 ppm
• CHIYERERO CHA CHROMTOGRAPHIC
Yankho A: 3.3 mg/mL ya tetrabutylammonium hydrogen sulfate
Gawo la m'manja: Acetonitrile ndi Solution A (2:3)
Njira yothetsera kuyenerera: 2 µg/mL iliyonse ya USP Acesulfame Potassium RS ndi ethylparaben
Njira yothetsera: 0.2 µg/mL ya USP Acesulfame Potassium RS
Yankho lachitsanzo: 10 mg/mL
Chromatographic system
(Onani Chromatography <621>, Kukwanira Kwadongosolo.)
Njira: LC
Chowunikira: UV 227 nm
Mzere: 4.6-mm × 25-cm;5-µm kunyamula L1
Kuthamanga: 1 mL / min
Kukula kwa jekeseni: 20µL
Kuyenerera kwadongosolo
Zitsanzo: Yankho lolingana ndi dongosolo
Zofunikira zoyenera
Kusamvana: NLT 2 pakati pa acesulfame potaziyamu ndi ethylparaben
Kusanthula
Zitsanzo: Yankho lokhazikika ndi yankho lachitsanzo
Lembani ma chromatogram kwa nthawi yothamanga NLT 3 nthawi yosungira nthawi ya acesulfame potaziyamu pachimake, ndipo yesani mayankho a dera la nsongazo.
Njira zolandirira: Kuyankha kwa nsonga iliyonse pa nthawi yosungira kupatula ya acesulfame potaziyamu kuchokera ku Sample solution sikudutsa kuyankha kwa acesulfame potaziyamu pachimake kuchokera ku Standard solution (0.002%).
MAYESO AKE
• ASIDITY KAPENA KUVUTA
Chitsanzo cha yankho: 4.0 g mu 20 ml ya madzi opanda mpweya woipa
Kusanthula: Onjezani 0,1 mL ya bromothymol blue TS.Ngati yankho lili lachikasu, titrate ndi 0.01 N sodium hydroxide kupanga mtundu wa buluu.Ngati yankho lili la buluu, titrate ndi 0.01 N hydrochloride acid kuti apange mtundu wachikasu.
Njira zolandirira: NMT 0.2 mL ya 0.01 N sodium hydroxide kapena NMT 0.2 mL ya 0.01 N hydrochloric acid ndiyofunika.
• KUTAYEKA PA KUYANTHA <731>: Yanikani chitsanzo pa 105° kwa 3 h: imataya NMT 1.0% ya kulemera kwake.
ZOWONJEZERA ZOFUNIKA
• KUPAKA NDI KUSUNGA: Sungani mu chidebe chotsekedwa bwino, ndikutetezani ku kuwala.Sungani kutentha.
MFUNDO ZA USP REFERENCE <11>
USP Acesulfame Potassium RS