Afatinib CAS 439081-18-2 Purity>99.5% (HPLC) Factory

Afatinib, yomwe imadziwikanso kuti BIW-2992, (CAS: 439081-18-2) ndi yachiwiri yamphamvu komanso yosasinthika yapawiri inhibitor ya epidermal growth factor receptor (EGFR) ndi human epidermal growth factor receptor 2 (HER2) tyrosine kinase, opangidwa ndi Boehringer Ingelheim, Germany.Imatha kuletsa mosasinthika ntchito ya tyrosine kinase pokumana ndi Michael reaction ndi gulu la thiol la cysteine ​​​​pamalo 797 a EGFR.Pa Julayi 12, 2013, idakhala mankhwala atsopano odana ndi khansa ya m'mapapo yaying'ono yovomerezedwa ndi US FDA pansi pa dzina la malonda la Gilotrif.Mankhwalawa ndi piritsi.Amagwiritsidwa ntchito pochiza odwala omwe ali ndi khansa ya m'mapapo yosakhala yaing'ono ya metastatic (NSCLC) ndikutayika kwa 19th exon kapena L858R mutation mu 21th exon ya chotupa epidermal growth factor receptor (EGFR) yotsimikiziridwa pogwiritsa ntchito zida zovomerezeka. ndi FDA.Mankhwalawa amagwiranso ntchito pochiza odwala omwe ali ndi HER2 omwe ali ndi khansa yapamwamba ya m'mawere.Afatinib ali m'gulu la mankhwala omwe amadziwika kuti tyrosine kinase inhibitors.Ma tyrosine kinase inhibitors adapangidwa kuti aletse kuchitapo kanthu kwa enzyme yotchedwa tyrosine kinase.Enzyme iyi imakhala ndi gawo lalikulu pakugwira ntchito kwa ma cell, ndipo imagwira ntchito polimbikitsa kukula ndi kukula kwa chotupa.Afatinib amagwira ntchito kuti alepheretse kugwira ntchito kwa mitundu iwiri ya tyrosine kinases: epidermal growth factor receptor (EGFR) ndi Her2, zomwe "zimawonetsedwa" ndi mitundu ingapo ya khansa.Poletsa kugwira ntchito kwa tyrosine kinases, Afatinib imatha kuteteza maselo a khansa kuti asagawikane ndikukula.