Afatinib Dimaleate CAS 850140-73-7 Purity >99.5% (HPLC) API

Afatinib Dimaleate (CAS: 850140-73-7), mtundu wa mchere wa dimaleate wa afanitib, ndi mankhwala omwe amapezeka pamlomo.Afatinib Dimaleate ndi EGFR family inhibitor yosasinthika yokhala ndi IC50s ya 0.5 nM, 0.4 nM, 10 nM ndi 14 nM ya EGFRwt, EGFRL858R, EGFRL858R/T790M ndi HER2, motsatana.Afatinib Dimaleate amasonyezedwa pamzere woyamba wa odwala omwe ali ndi khansa ya m'mapapo yosakhala yaing'ono ya metastatic (NSCLC) omwe zotupa zawo zimakhala ndi epidermal growth factor receptor (EGFR) exon 19 deletions kapena exon 21 (L858R) monga zazindikirika ndi FDA- mayeso ovomerezeka.M'mbuyomu, chithandizo chokhazikika chogwiritsa ntchito platinum-based chemotherapy doublet regimen chimatengedwa ngati chithandizo choyambirira cha odwala onse omwe ali ndi NSCLC.Komabe, umboni womwe ukuwonekera wapeza kuti anthu ochepa omwe amathandizidwa nawo amakhala othandiza kwambiri, zomwe zimapangitsa kuti pakhale mankhwala omwe amasintha kusintha.Afatinib Dimaleate Adapangidwa ndi Boehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate adavomerezedwa ndi FDA mu 2013 ngati mankhwala amasiye omwe amatchedwa Gilotrif.Afatinib Dimaleate amapangidwa ndi mankhwala pogwiritsa ntchito njira zokhazikika.Afatinib Dimaleatesichimangogwira ntchito motsutsana ndi kusintha kwa EGFR komwe kumayendetsedwa ndi TKIs ya m'badwo woyamba monga erlotinib kapena gefitinib, komanso motsutsana ndi masinthidwe monga T790M omwe sakhudzidwa ndi machiritso awa.Chifukwa cha ntchito yake yowonjezera yolimbana ndi Her2, ikufufuzidwa za khansa ya m'mawere komanso khansa zina zoyendetsedwa ndi EGFR ndi Her2.