Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity>99.0% (HPLC) Factory

Kufotokozera Kwachidule:

Dzina Lamankhwala: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Kuyera: > 99.0% (HPLC)

Maonekedwe: Ufa Wachikasu Wopepuka mpaka Wachikasu

Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Zogwirizana nazo

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Kufotokozera:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineChithunzi cha CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Dzina la Chemical	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Mawu ofanana ndi mawu	N4-(3-Chloro-4-Fluorophenyl) -7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib Chidetso B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Nambala ya CAS	314771-76-1
Nambala ya CAT	RF-PI2028
Stock Status	Mu Stock, Mphamvu Yopanga 100MT/Chaka
Molecular Formula	C18H16ClFN4O2
Kulemera kwa Maselo	374.8
Boiling Point	559.0±50.0℃
Kuchulukana	1.473±0.060 g/cm3
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Wachikasu Wopepuka mpaka Wachikasu
Chizindikiritso	Nthawi Yosungitsa Pansonga Yaikulu mu HPLC Iyenera Kugwirizana ndi Muyezo
Kuyera / Kusanthula Njira	>99.0% (HPLC)
Kutaya pa Kuyanika	<0.50%
Zotsalira pa Ignition	<0.20%
Chidetso Chimodzi	<0.50%
Zonse Zonyansa	<1.00%
Zitsulo Zolemera (monga Pb)	≤20ppm
Test Standard	Enterprise Standard
Kugwiritsa ntchito	Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala

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Ubwino:

FAQ:

Ntchito:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) ndi wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7).Afatinib ndi m'badwo wachiwiri wamphamvu komanso wosasinthika wapawiri woletsa wa epidermal growth factor receptor (EGFR) ndi human epidermal growth factor receptor 2 (HER2) tyrosine kinase, yopangidwa ndi Boehringer Ingelheim, Germany.Imatha kuletsa mosasinthika ntchito ya tyrosine kinase pokumana ndi Michael reaction ndi gulu la thiol la cysteine pamalo 797 a EGFR.Ntchito: 1. Mofanana ndi Lapatinib ndi Neratinib, Afatinib ndi protein kinase inhibitor yomwe imalepheretsanso kuti munthu asawonongeke epidermal growth factor receptor 2 (Her2) ndi epidermal growth factor receptor (EGFR) kinases.2. Afatinib samangogwira ntchito motsutsana ndi kusintha kwa EGFR komwe kumayang'aniridwa ndi TKIs ya m'badwo woyamba monga erlotinib kapena gefitinib, komanso motsutsana ndi masinthidwe monga T790M omwe sakhudzidwa ndi mankhwalawa.Chifukwa cha ntchito yake yowonjezera yolimbana ndi Her2, ikufufuzidwa za khansa ya m'mawere komanso khansa zina zoyendetsedwa ndi EGFR ndi Her2.3. Afatinib ndi mankhwala ochizira odwala omwe ali ndi mitundu yosiyana ya metastatic (EGFR mutation positive) yopanda cell lung carcinoma (NSCLC).Imakhala ngati inhibitor yosasinthika ya covalent inhibitor ya receptor tyrosine kinases epidermal growth factor receptor (EGFR) ndi erbB-2 (HER2).