Apixaban CAS 503612-47-3 Purity ≥99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga Apixaban (CAS: 503612-47-3) okhala ndi mawonekedwe apamwamba.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Apixaban,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Apixaban |
| Mawu ofanana ndi mawu | 1-(4-Methoxyphenyl) -7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1- (4-methoxyphenyl) -7-oxo-6-[4-(2-oxo-1-piperidinyl) phenyl] -1H-pyrazolo[3, 4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 503612-47-3 |
| Molecular Formula | C25H25N5O4 |
| Kulemera kwa Maselo | 459.51 g / mol |
| Melting Point | 235.0 ~ 238.0 ℃ |
| Kuchulukana | 1.42 |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Gulu | API |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Wa Crystalline Woyera mpaka Woyera | Zimagwirizana |
| Kutaya pa Kuyanika | ≤0.50% | 0.10% |
| Zotsalira pa Ignition | ≤0.10% | 0.08% |
| Zitsulo Zolemera (monga Pb) | ≤20ppm | Zimagwirizana |
| Zogwirizana nazo | ||
| Chidetso Chilichonse Chilichonse | ≤0.50% | Zimagwirizana |
| Zonse Zonyansa | ≤0.50% | Zimagwirizana |
| Kuyera / Kusanthula Njira | ≥99.5% (HPLC) | 99.9% |
| Infrared Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| 1 H NMR Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zanenedwa | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Palibe chilichonse mwazinthu zomwe chidzaperekedwa kumayiko omwe izi zitha kukhala zosemphana ndi zovomerezeka zomwe zilipo.Komabe udindo womaliza uli ndi wogula.
Zogwiritsa ntchito kafukufuku wasayansi kokha, osati pazifukwa zilizonse zamalonda, osati zamunthu kapena zowunikira.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Apixaban (CAS: 503612-47-3) ndi njira yatsopano ya mankhwala oral anticoagulant opangidwa ndi Bristol Myers Squibb ndi Pfizer.Ndi mtundu watsopano wa oral Xa factor inhibitor, ndipo dzina lake lamalonda ndi Eliquis.Apixaban amagwiritsidwa ntchito pochiza odwala akuluakulu omwe akuchitidwa opaleshoni ya m'chiuno kapena mawondo kuti ateteze venous thromboembolism (VTE)
Apixaban (CAS: 503612-47-3) ndi oral selective activated Xa factor inhibitor ndipo imatha kuteteza kubadwa kwa thrombin ndi thrombosis.
Apixaban (CAS: 503612-47-3) ndi mankhwala achitatu atsopano a anticoagulant kuti agulitse, kutsatira dabigatran ndi rivaroxaban, ndipo avomerezedwa kale ku Ulaya pofuna kupewa venous thromboembolism kwa odwala omwe akuchitidwa opaleshoni yosankha m'chiuno kapena mawondo.Mwa ma anticoagulants awa atatu omwe amavomerezedwa ku Europe, poyerekeza ndi njira yodzitetezera yomwe ilipo masiku ano motsutsana ndi venous thromboembolism, enoxaparin, rivaroxaban adapambana pakuyesa kwa mbiri, ndipo apixaban adachita bwino pakuyesa pasadakhale.Machiritso a Rivaroxaban anali apamwamba pang'ono, koma adayambitsa magazi ambiri kuposa apixaban.Ochita kafukufuku adanena kuti kusiyana kumeneku ndi nthawi ya mankhwala, monga rivaroxaban inatengedwa maola 6-8 pambuyo pa opaleshoni muzoyesera zolembera, pamene apixaban inagwiritsidwa ntchito maola 18 pambuyo pa opaleshoni poyesera pasadakhale.Mankhwalawa amachiritsa bwino akagwiritsidwa ntchito pafupi ndi nthawi ya opaleshoni, komanso amakhala ndi chiwopsezo chochulukira magazi.Kafukufuku wachipatala anasonyeza kuti poyerekeza ndi jekeseni wa tsiku ndi tsiku wa 40mg enoxaparin, 2 oral 2.5mg Mlingo wa apixaban anali ndi zotsatira zabwino zotetezera motsutsana ndi venous thromboembolism pambuyo pa opaleshoni ya m'chiuno kapena m'mawondo ndipo sizinawonjezeke magazi.
Apixaban (CAS: 503612-47-3) ndi mtundu watsopano wa oral Xa factor inhibitor wopangidwa pamodzi ndi Bristol-Myers Squibb ndi Pfizer.Dzina lamalonda ndi eratol, lomwe ndi mtundu watsopano wa anticoagulant wapakamwa.Poletsa coagulation factor Xa, apixaban imatha kuletsa kupanga thrombin ndi thrombosis.Pa Epulo 26, 2007, Bristol-Myers Squibb adalumikizana ndi Pfizer kulengeza mgwirizano pakupanga apixaban oral anticoagulant ya Bristol-Myers Squibb ngati njira yopititsira patsogolo ya warfarin.Malinga ndi mgwirizano wa mgwirizano, Pfizer adzalipira $ 0.25 biliyoni ya US $ 0.25 biliyoni ku Bristol-Myers Squibb kuti apereke 60% ya mtengo wonse wa chitukuko cha anticoagulant apixaban (yoyenera kukhazikitsidwa kuyambira January 1, 2007), pamene Bristol-Myers. Squibb adzakhala ndi 40% yotsala, motero kupeza ufulu pamodzi kupanga ndi kugulitsa mankhwala.Mu May 2011, apixaban anali woyamba kuvomereza kupewa venous thrombosis kwa odwala akuluakulu omwe amachitidwa opaleshoni yosankha m'chiuno kapena mawondo m'mayiko a 27 EU, Iceland ndi Norway.Pa November 20, 2012, European Commission inavomereza Ererto (apixaban) pofuna kupewa matenda a stroke ndi systemic embolism kwa odwala akuluakulu omwe ali ndi non-valvular atrial fibrillation (NVAF) omwe ali ndi chiopsezo chimodzi kapena zingapo.Pambuyo pake, Canadian Food and Drug Administration, Japan, ndi US FDA idavomereza Ererto?(apixaban) pofuna kupewa matenda a stroke ndi systemic embolism mwa odwala akuluakulu omwe ali ndi vuto lopanda valvular atrial fibrillation (NVAF) omwe ali ndi chiopsezo chimodzi kapena zingapo.Pa Epulo 12, 2013, mankhwala atsopano a anticoagulant Eloto (ELIQUIS) (apixaban) opangidwa ndi Bristol-Myers Squibb ndi Pfizer adalengezedwa kuti alembedwa ku China.Ererto ndi buku la oral factor Xa inhibitor popewa kupewa venous thromboembolism (VTE) mwa odwala akuluakulu omwe amasankhidwa m'chiuno kapena mawondo.Mndandanda wake umapereka chisankho chatsopano chotetezeka komanso chothandiza cha anticoagulation yachipatala pambuyo pa opaleshoni ya mafupa, ndipo imabweretsa uthenga wabwino kwa odwala aku China omwe akusinthidwa m'chiuno / bondo.chipatala maphunziro atsimikizira kuti poyerekeza ndi 40mg enoxaparin kamodzi patsiku, 2 pa tsiku m`kamwa makonzedwe a eratol?(apixaban) 2.5mg ndi yothandiza kwambiri poletsa venous thromboembolism pambuyo pa opaleshoni ya m'chiuno kapena mawondo, ndipo sichiwonjezera chiopsezo chotaya magazi.Chithunzi 1 chikuwonetsa mapiritsi a Elotoapixaban opangidwa ndi Bristol-Myers Squibb ndi Pfizer.
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