Aripiprazole CAS 129722-12-9 Purity>99.0% (HPLC) API
Opanga Opanga Apakati a Aripiprazole Ndi Kuyera Kwambiri
Aripiprazole API CAS 129722-12-9
1-(2,3-Dichlorophenyl) piperazine Hydrochloride CAS 119532-26-2
7-Hydroxy-3,4-Dihydro-2(1H)-Quinolinone CAS 22246-18-0
7-(4-Bromobutoxy)-3,4-Dihydro-2(1H)-Quinolinone CAS 129722-34-5
| Dzina la Chemical | Aripiprazole |
| Mawu ofanana ndi mawu | 7-[4-[4-(2,3-Dichlorophenyl)-1-Piperazinyl]butoxy]-3,4-Dihydro-2(1H) -Quinolinone |
| Nambala ya CAS | 129722-12-9 |
| Nambala ya CAT | RF-PI2270 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C23H27Cl2N3O2 |
| Kulemera kwa Maselo | 448.39 |
| Kusungunuka | Zosasungunuka m'madzi;Insoluble mu Methanol |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera Kapena Woyera Wamakristalo |
| Chizindikiritso | Ndi IR;Ndi HPLC |
| Kusungunuka | Kusungunuka mu Acetic Acid, Kusungunuka Pang'ono Mu Ethanol |
| Melting Point | 136.0 ~ 140.0 ℃ |
| Kutaya pa Kuyanika | <0.50% |
| Zotsalira pa Ignition | <0.10% |
| Zitsulo Zolemera | ≤20ppm |
| Zosungunulira Zotsalira | |
| Ethanol | ≤1000ppm |
| DMF | ≤200ppm |
| Zogwirizana nazo | |
| Chidetso Chilichonse Chilichonse | <0.20% |
| Zonse Zonyansa | <1.00% |
| Kuyera / Kusanthula Njira | >99.0% (HPLC) |
| Kuyesa | 98.0% ~ 102.0% (pa Anhydrous Basis) |
| Malire a Micro | |
| Total Aerobic Microbial Count | ≤1000 cfu/g |
| Yisiti ndi Mold Zophatikizidwa | ≤100 cfu/g |
| E Koli | Kusowa |
| Kukonzekera kwa Pathogenic | Kusowa |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API;Antipsychotic |
Phukusi: Botolo, 5kg / Aluminiyamu malata, 25kg / Cardboard Drum, kapena malinga ndi lamulo la kasitomala
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi
Aripiprazole (CAS: 129722-12-9) ndi mtundu watsopano wa lipid soluble quinoline zotumphukira, zotsatira zake za pharmacological ndikuti sikuti ndi postsynaptic dopamine D2 receptor antagonist, komanso presynaptic dopamine D2 receptor agonist, imathanso. sangalatsani D1, D3, D4 receptors.Aripiprazole ndi m'badwo wachiwiri wa atypical antipsychotic komanso anti-depressant wokhala ndi gawo la agonist pa dopamine D2 ndi serotonin 5-HT1A zolandilira ndi zochita zotsutsana ndi serotonin 5-HT2A receptors.Makhalidwe a Ki ndi 0.34 nM, 0.8 nM, 1.7 nM, ndi 3.4 nM, motero, kwa dopamine D2 ndi D3, serotonin 5-HT1A ndi 5-HT2A receptors.Aripiprazole amagwiritsidwa ntchito pochiza schizophrenia ndi zovuta zokhudzana ndi psychotic.Bristol-Myers Squibb ndi Otsuka Pharmaceutical Company yalengeza kuti European Union yavomereza Abilify (Aripiprazole) pochiza ndandanda ya schizophrenia.Schizophrenia imakhudza 1% ya anthu padziko lonse lapansi, ndipo zambiri mwa achinyamata.Schizophrenia imakhudza kuganiza, kuwongolera malingaliro ndi kuthekera kopanga zisankho kwa wodwalayo.Odwala omwe ali ndi schizophrenia adzakhala ndi zizindikiro monga kuyerekezera zinthu m'maganizo ndi chinyengo, odwala omwe ali ndi zizindikiro zoipa amasiya kucheza, kusowa kwa kusintha kwa maganizo.Mu 2002 a FDA adavomereza Abilify kuti azichiza schizophrenia, yomwe ili ndi mphamvu zisanu za mlingo: 5 mg, 10 mg, 15 mg, 20 mg ndi 30 mg, kuyambira pomwe idavomerezedwa.
