Atazanavir CAS 198904-31-3 Purity ≥99.0% API Factory Anti-HIV HIV-1 Protease Inhibitor

Atazanavir (CAS 198904-31-3) ndi antiretroviral, novel komanso azapeptide amphamvu a gulu la protease inhibitor (PI).Amagulitsidwa pansi pa dzina la malonda Reyataz.Monga ma antiretrovirals ena, amagwiritsidwa ntchito pochiza matenda amtundu wa 1 (HIV-1) protease enzyme ndi chopinga nthawi zonse Ki wa 66 nmol/L komanso amalepheretsa kugawanika kwa kachilombo ka HIV-1 ndi 50% ogwira mtima ndende EC50 kuyambira 2.6 mpaka 5.3 nmol/L.Atazanavir amamanga ku HIV-1 protease kuteteza kugawanika kwa gag ndi gag-pol polyproteins, zomwe zimapangitsa kupanga ma virioni osakhwima m'maselo omwe ali ndi kachilombo ka HIV-1.Atazanavir ili ndi mawonekedwe osiyana a C-2 a ma symmetric chemical structure komanso mphamvu yowonjezereka ya ma antiretroviral mu mitundu yosiyanasiyana ya HIV poyerekeza ndi ma protease inhibitors ena, kuphatikizapo Indinavir, Nelfinavir, Ritonavir, Saquinavir ndi Amprenavir.Atazanavir imasiyanitsidwa ndi ma PI ena chifukwa imatha kuperekedwa kamodzi patsiku ndipo imakhala ndi zotsatira zochepa pa mbiri ya lipid ya wodwalayo.Monga ma protease inhibitors ena, amagwiritsidwa ntchito limodzi ndi mankhwala ena a HIV.Atazanavir ndi buku la azapeptide HIV protease inhibitor.Antivayirasi.Amatengedwa pakamwa kamodzi patsiku.