Bacitracin Zinc CAS 1405-89-6 Potency ≥70 IU/mg Peptide Antibiotic Factory
Shanghai Ruifu Chemical Co., Ltd. ndi amene amapanga ndi kugulitsa Bacitracin Zinc (Zinc Bacitracin) (CAS: 1405-89-6) yokhala ndi khalidwe lapamwamba.Titha kupereka COA, kutumiza padziko lonse lapansi, zochepa komanso zochulukirapo zomwe zilipo.Ngati mukufuna Bacitracin Zinc (Zinc Bacitracin),Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Zinc ya Bacitracin |
| Mawu ofanana ndi mawu | Bacitracin Zinc Mchere;Zinc Bacitracin |
| Stock Status | Mu Stock, Mphamvu Yopanga Matani 10 pachaka |
| Nambala ya CAS | 1405-89-6 |
| Molecular Formula | Chithunzi cha C66H101N17O16SZn |
| Kulemera kwa Maselo | 1486.07 |
| Melting Point | 250 ℃ (Dec.) |
| Kusungunuka kwamadzi | 5.1g/L |
| COA & MSDS | Likupezeka |
| Chitsanzo | Likupezeka |
| Mtundu | Ruifu Chemical |
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | White kapena Light Yellow-Gray kapena Beige Ufa | Zimagwirizana |
| Chizindikiritso | Pezani Zofunikira | Zowoneka Zabwino |
| pH | 6.0-7.5 | 7.1 |
| Kutaya pa Kuyanika | ≤5.0% | 2.7% |
| Zinc (Chinthu Chouma) | 4.0% ~ 6.0% | 4.20% |
| Mphamvu | ≥70 IU/mg Microbial Assay (Maziko Ouma) | 71 IU/mg |
| Zomwe zili mu Bacitracin A | ≥40.0% | 58.2% |
| Zomwe zili mu Active Bacitracin | ≥70.0% (Bacitracin A, B1, B2, ndi B3) | 86.1% |
| Malire a Eluting Peptides Oyambirira | ≤20.0% | 7.6% |
| Malire a Bacitracin F | ≤6.0% | 1.1% |
| Total Viable Aerobic Count | <100 CFU/gram | Zimagwirizana |
| Mapeto | Zogulitsazo Zimagwirizana ndi Miyezo ya USP44 | |
| Kugwiritsa Ntchito Kwambiri | Peptide Antibiotic | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Bacitracins, zinc complex.
Bacitracins zinc zovuta [1405-89-6].
» Bacitracin Zinc ndi zinc complex ya bacitracin, yomwe imakhala ndi antimicrobial polypeptides, zigawo zikuluzikulu zomwe zimakhala bacitracins A, B1, B2, ndi B3.Ali ndi mphamvu zosachepera 65 Bacitracin Units pa mg, owerengedwa pa zouma.Lili ndi osachepera 4.0 peresenti komanso osapitirira 6.0 peresenti ya nthaka (Zn), yowerengedwa pa zouma.
Kuyika ndi kusunga- Sungani m'mitsuko yothina, ndikusunga pamalo ozizira.
Lembetsani-Lembetsani kuti muwonetse kuti iyenera kugwiritsidwa ntchito popanga mankhwala osabereka okha.Kumene imapakidwa kuti ipangidwe ndi mankhwala, ilembeni kuti iwonetsere kuti ilibe kachilombo komanso kuti potency sangatsimikizidwe kwa nthawi yaitali kuposa masiku 60 mutatsegula, ndikufotokozera chiwerengero cha Mayunitsi a Bacitracin pa milligram.Kumene amayenera kugwiritsidwa ntchito popanga mafomu a mlingo wosabala, chizindikirocho chimati ndi wosabala kapena akuyenera kukonzedwanso panthawi yokonzekera mafomu a mlingo wosabala.
Miyezo yolozera ya USP <11>-
USP Bacitracin Zinc RS
Chizindikiritso-
A: Thin-Layer Chromatographic Identification Test <201BNP>: imakwaniritsa zofunikira.
B: Imakwaniritsa zofunikira za njira yamadzimadzi ya chromatographic pakuyesa kwa Composition.
Sterility <71>-Kumene chizindikirocho chikunena kuti ndi chosabala, chimakwaniritsa zofunikira zikayesedwa monga momwe zalembedwera Kusefera kwa Membrane pansi pa Test for Sterility of Product kuti Kuyesedwa, kupatula kugwiritsa ntchito Fluid A ku L iliyonse yomwe yawonjezeredwa 20 g wa edetate disodium.
pH <791>: pakati pa 6.0 ndi 7.5, mu njira (yodzaza) yomwe ili ndi pafupifupi 100 mg pa mL.
Kutaya pakuyanika <731>-Unikani pafupifupi 100 mg mu botolo la capillary-stoppered mu vacuum pa 60 kwa maola atatu: imataya osapitirira 5.0% ya kulemera kwake.
Zinc zomwe zili - [Zindikirani-Kukonzekera kwa Standard ndi Kukonzekera kwa Mayeso kumatha kuchepetsedwa mochulukira ndi 0.001 N hydrochloric acid, ngati kuli kofunikira, kuti mupeze mayankho okhazikika oyenera, osinthika ndi mzere kapena magwiridwe antchito a chida.]
Kukonzekera kokhazikika-Kusamutsa 3.11 g wa zinc oxide, woyezedwa molondola, ku botolo la volumetric 250-mL, onjezerani 80 mL wa 1 N hydrochloric acid, kutentha kuti asungunuke, kuziziritsa, kusungunula ndi madzi ku voliyumu, ndi kusakaniza.Njirayi ili ndi 10 mg ya zinki pa mL.Komanso chepetsani yankholi ndi 0.001 N hydrochloric acid kuti mupeze zokonzekera Zokhazikika zomwe zili ndi 0.5, 1.5, ndi 2.5 µg wa zinki pa mL, motsatana.
Kukonzekera mayeso-Kutumiza pafupifupi 200 mg ya Bacitracin Zinc, yoyezedwa molondola, ku botolo la volumetric 100-mL.Sungunulani mu 0.01 N hydrochloric acid, sungunulani ndi zosungunulira zomwezo mpaka voliyumu, ndikusakaniza.Pipeni 2 ml ya yankho ili mu botolo la volumetric 200-mL, sungunulani ndi 0.001 N hydrochloric acid mpaka voliyumu, ndikusakaniza.
Dongosolo-Mofananira kudziwa absorbances wa Kukonzekera Standard ndi kukonzekera Mayeso pa zinc resonance mzere wa 213.8 nm, ndi oyenera atomiki mayamwidwe spectrophotometer (onani Spectrophotometry ndi kuwala-kubalalitsa <851>), okonzeka ndi zinc dzenje-cathode nyali ndi lawi la air-acetylene, pogwiritsa ntchito 0.001 N hydrochloric acid monga chopanda kanthu.Konzani mayamwidwe a zokonzekera za Standard motsutsana ndi kuchuluka kwake, mu µg pa mL, zinki, ndipo jambulani mzere wowongoka womwe ukugwirizana bwino ndi mfundo zitatu zomwe zakonzedwa.Kuchokera pa graph yomwe yapezedwa, dziwani kuchuluka kwa zinc mu µg pa mL pakukonzekera Mayeso.Werengani zomwe zili zinki, mu peresenti, mu gawo la Bacitracin Zinc lomwe latengedwa ndi formula:
1000C / W
momwe C ndi ndende mu µg pa mL, zinki mu Kukonzekera Mayeso;ndipo W ndiye kulemera, mu mg, kwa gawo la Bacitracin Zinc lomwe latengedwa.
Kupanga-
Buffer- Sungunulani 34.8 g wa potassium phosphate, dibasic, mu 1 L madzi.Sinthani ndi 27.2 g wa potaziyamu phosphate, monobasic, kusungunuka mu 1 L madzi, kuti pH ya 6.0.
Mobile Phase-Konzani chisakanizo cha methanol, madzi, Buffer, ndi acetonitrile (26:15:5:2).Sakanizani bwino, ndi degas.
Diluent - Sungunulani 40 g wa edetate disodium mu 1 L madzi.Sinthani ndi dilute sodium hydroxide kukhala pH ya 7.0.
System suitability solution-Sungani muyeso woyezedwa bwino wa USP Bacitracin Zinc RS mu Diluent kuti mupeze yankho lomwe lili ndi kuchuluka kwa pafupifupi 2.0 mg pa mL.
Kupereka lipoti pofikira yankho-Dilute mochulukira, ndi madzi, voliyumu yoyenera ya njira yothetsera vutoli kuti mupeze yankho lodziwika bwino la 0.01 mg pa ml.
Peak identification solution-Sungani muyeso woyezera wa USP Bacitracin Zinc RS mu voliyumu yoyenera ya Diluent kuti mupeze yankho lomwe lili ndi kuchuluka kwa pafupifupi 2.0 mg pa mL.Kutenthetsa mu osamba madzi otentha kwa mphindi 30.Kuzizira mpaka kutentha.
Sungunulani mulingo woyezera bwino wa Zinc wa Bacitracin mu Diluent kuti mupeze yankho lomwe lili ndi kuchuluka kwa pafupifupi 2.0 mg pa mL.
Chromatographic system (onani Chromatography <621>) - Chromatograph yamadzimadzi imakhala ndi chojambulira choyamwitsa komanso ndime yotsekera 4.6- × 250-mm yomwe ili ndi 5-µm packing L1.Kuthamanga kwa magazi ndi 1.0 ml pa mphindi.Khazikitsani kutalika kwa detector pa 300 nm.Jayini pafupifupi 100 µL ya njira yozindikiritsa ya Peak, ndipo zindikirani malo a bacitracin F, omwe ndi chodetsa chodziwika bwino, pogwiritsa ntchito nthawi yosungira yomwe ikuwonetsedwa mu Tebulo 1.
Table 1
Dzina lachigawo Nthawi Yosunga (pafupifupi)
Bacitracin C1 0.5
Bacitracin C2 0.6
Bacitracin C3 0.6
Bacitracin B1 0.7
Bacitracin B2 0.7
Bacitracin B3 0.8
Bacitracin A 1.0
Bacitracin F 2.4
Sinthani kutalika kwa detector ndikuyiyika ku 254 nm.Chromatograph the System suitability solution, ndipo lembani mayankho apamwamba monga momwe adayankhira Ndondomeko: zindikirani nsonga za zigawo zomwe zimagwira ntchito kwambiri za bacitracin (bacitracins A, B1, B2 ndi B3), ma peptides oyambirira (omwe akutuluka chisanachitike chifukwa cha bacitracin B1). ) ndi zodetsedwa, bacitracin F, pogwiritsa ntchito nthawi yosunga nthawi yomwe yaperekedwa mu Tebulo 1. Yerekezerani kuchuluka kwa chigwacho pogwiritsa ntchito njirayi:
Hp / HV
momwe Hp ndi kutalika pamwamba pa maziko a nsonga chifukwa cha bacitracin B1;ndipo HV ndi kutalika pamwamba pa maziko a malo otsika kwambiri a mphira wolekanitsa nsonga ya bacitracin B1 kuchokera pachimake chifukwa cha bacitracin B2.Chiŵerengero chapamwamba-ku-chigwa sichicheperachepera 1.2.
Njira-Ikani jekeseni ma voliyumu ofanana (100 µL) a Diluent, Test solution, and Reporting threshold solution.Lembani ma chromatogram pafupifupi katatu nthawi yosungira ya bacitracin A. Dziwani nsonga zake pogwiritsa ntchito nthawi yosungira yomwe yasonyezedwa mu Gulu 1. Yezerani nsonga za nsonga zonse mu Njira Yoyesera.[Zindikirani-Musanyalanyaze nsonga iliyonse mu Njira Yoyesera yokhala ndi malo ocheperapo kuposa gawo la bacitracin A pachimake panjira ya Lipoti;musanyalanyaze nsonga iliyonse yowonedwa mu Diluent.]
note-Total area mu mawerengedwe otsatirawa amatanthauzidwa ngati malo a nsonga zonse kupatula malire operekera malipoti.
Zomwe zili mu bacitracin a-Yerekezerani kuchuluka kwa bacitracin A pogwiritsa ntchito ndondomekoyi:
(rA / Malo onse) × 100
momwe rA ndi gawo loyankhidwa kuchokera ku bacitracin A. Bacitracin A zomwe zili ndizomwe sizichepera 40.0% ya Total area.
Zomwe zili mu bacitracin-Yerekezerani kuchuluka kwa bacitracin (bacitracin A, B1, B2, ndi B3) pogwiritsa ntchito ndondomekoyi:
(rA + rB1 + rB2 + rB3 / Malo onse)×100
momwe rA, rB1, rB2, ndi rB3 ndi mayankho ochokera ku bacitracin A, B1, B2, ndi B3 motsatana.Kuchuluka kwa bacitracin A, B1, B2, ndi B3 sikuchepera 70.0% ya Total dera.
malire a ma peptide oyambilira -Werengetsani kuchuluka kwa nsonga zonse zomwe zafika pachimake chifukwa cha bacitracin B1 pogwiritsa ntchito njira iyi:
(rPreB1 / Total area) ×100
momwe rPreB1 ndi chiwerengero cha mayankho a nsonga zonse zomwe zatsala pang'ono kufika pachimake cha bacitracin B1.Malire a ma peptides oyambilira (omwe amatuluka pachimake chifukwa cha bacitracin B1) saposa 20.0%.
malire a bacitracin f- Werengani kuchuluka kwa bacitracin F pogwiritsa ntchito ndondomekoyi:
100 × (rF / rA)
momwe rF ndi yankho la bacitracin F kuchokera ku Test solution;ndipo rA ndi yankho la bacitracin A kuchokera ku Test solution.Malire a bacitracin F, chonyansa chodziwika bwino, sichiposa 6.0%.
Assay-Pitirizani ndi Bacitracin Zinc monga mwalangizidwa pansi pa Antibiotics-Microbial Assays 81.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Bacitracin amachotsedwa mu njira ya chikhalidwe cha lichen (Bacillus licheniformis) ndipo ndi mankhwala a polypeptide.ufa woyera kapena wopepuka wachikasu, wopanda fungo kapena wonunkhira pang'ono, kukoma kowawa, hygroscopic.Mosavuta sungunuka m'madzi ndi Mowa, wosakhazikika, madzi amadzimadzi njira mosavuta inactivated kutentha firiji, wosakhazikika pa pH 9, ndipo ayenera firiji mu firiji pambuyo kuvunda.Mankhwalawa amawerengedwa ngati mankhwala owuma, ndipo titer pa milligram siyenera kuchepera mayunitsi 55 a bacitracin.Bacitracin zinc ndi mchere wa bacitracin zinki, womwe ndi wokhazikika kuposa bacitracin.Amagwiritsidwa ntchito ngati chowonjezera cha chakudya ndipo ali ndi ntchito zolimbikitsa kukula ndi chitukuko cha ziweto ndi nkhuku, kuteteza matenda a m'mimba, ndi kuonjezera malipiro a chakudya.Mlingo wake ndi wofanana ndi bacitracin.Bacitracin antibacterial spectrum ndi ofanana ndi penicillin, yomwe imakhala ndi mphamvu yolimbana ndi mabakiteriya a gram-positive komanso osakhudza mabakiteriya opanda gram.Kwa matenda oopsa a Staphylococcus aureus osamva mankhwala.Kuwongolera pakamwa sikumatengedwa ndipo kumagwiritsidwa ntchito pa matenda a m'mimba.Kugwiritsiridwa ntchito kwakunja kumathandizanso pa thupi, matenda amkamwa ndi maso komanso mastitis omwe amayamba chifukwa cha mabakiteriya okhudzidwa.Amawononga impso.Zinc ya Bacitracin yagwiritsidwa ntchito ngati chowonjezera chamankhwala.Kuwongolera m'kamwa sikumakhudzidwa, choncho anthu ambiri amakhulupirira kuti palibe vuto la zotsalira za mankhwala pa ziweto ndi nkhuku.Mankhwalawa ndi opapatiza-sipekitiramu maantibayotiki, amene ali amphamvu antibacterial zotsatira pa ambiri gram-positive mabakiteriya.Zimagwiranso ntchito polimbana ndi spirochetes ndi actinomycetes, koma sizothandiza polimbana ndi mabakiteriya a gram-negative.Lili ndi synergistic kwenikweni ndi zosiyanasiyana maantibayotiki monga penicillin G, streptomycin, neomycin, polymyxin, etc. Zinc mchere wake zimagwiritsa ntchito ngati chakudya chowonjezera, amene ali ndi ntchito zopewera matenda m`mimba, kulimbikitsa kukula ndi kuwongolera chakudya malipiro.Mabakiteriya amatha kukula pang'onopang'ono kukana mankhwalawa, koma palibe kutsutsana pakati pa mankhwalawa ndi maantibayotiki ena.Mankhwalawa ndi oopsa kwambiri ndipo sangathe kubayidwa.Itha kumwedwa pakamwa pochiza kutsekula m'mimba kwa bakiteriya mu ziweto ndi Treponema kamwazi mu nkhumba.Kachipatala, nthawi zambiri amagwiritsidwa ntchito limodzi ndi maantibayotiki osiyanasiyana monga penicillin, streptomycin, neomycin, polymyxin B, etc. kuti apititse patsogolo mphamvu zake.
Bacitracin Zinc ndizovuta zomwe zimapangidwa ndi bacitracin ndi ayoni zinc.ndi polypeptide antibiotic ndipo ndi mankhwala opha tizilombo omwe amagwiritsidwa ntchito kwambiri pakali pano.Zinc zili ndi 2% ~ 12%.Zopangira zopangidwa ndi ufa woyera kapena wachikasu, wokhala ndi fungo lapadera, zosavuta kusungunuka muzinthu zamchere zofooka, komanso zimasungunuka mosavuta m'madzi, methanol ndi ethanol.Zinc ya Bacitracin imakhala ndi mphamvu yolimbana ndi mabakiteriya a gram-positive, komanso imakhala ndi antibacterial properties motsutsana ndi mabakiteriya a gram-negative.Kugwiritsa ntchito zinki ya bacitracin mu chakudya cha nkhumba kumatha kulimbikitsa kukula, kupititsa patsogolo malipiro a chakudya, komanso kupewa kutsekula m'mimba kwa nkhumba ndi matenda osapumira.Kuphatikizika kowonjezerako nthawi zambiri kumakhala 10 ~ 100mg/kg, ndipo zotsatira zake sizili bwino kwambiri kuposa kuchuluka kwake.Zinc ya Bacitracin nthawi zambiri samalowa m'matumbo a nkhumba, kotero palibe vuto lotsalira.Ndiwotetezeka komanso wodalirika wowonjezera ma antibiotic.Zinc ya Bacitracin ndi poizoni kwambiri ndipo satengeka mosavuta ndi matumbo, choncho sangagwiritsidwe ntchito ngati mankhwala a matenda a m'thupi.
Maantibayotiki a polypeptide ali ndi antibacterial amphamvu pa mabakiteriya a gramu, komanso amakhala ndi antibacterial pa mabakiteriya ochepa a gram-negative, spirochetes, actinomycetes komanso staphylococci yosamva penicillin.Njira ya antibacterial ndikuletsa mapangidwe a cell cell ya bakiteriya ndikuwononga nembanemba ya bakiteriya cell plasma.Ikhoza kulimbikitsa kukula kwa tizilombo toyambitsa matenda m'matumbo, kuonjezera permeability wa mucosa m'mimba, ndikulimbikitsa kuyamwa kwa zakudya.Amagwiritsidwa ntchito makamaka kulimbikitsa kukula kwa ziweto ndi nkhuku, kuteteza ndi kuletsa kutsekula m'mimba kwa bakiteriya kwa ziweto ndi nkhuku ndi magazi a kamwazi omwe amayamba chifukwa cha Treponema.Zinc ya bacitracin imalowetsedwa m'kati mwake, ndipo zambiri zimachotsedwa ndi ndowe mkati mwa masiku a 2, kotero sikophweka kukhalabe mu ziweto ndi nkhuku;Kaŵirikaŵiri mabakiteriya sayamba kukana bacitracin, ndipo salimbana ndi maantibayotiki ena, Ndipo amagwira ntchito limodzi ndi penicillin, streptomycin, neomycin, aureomycin, polymyxin, ndi zina zotero.Mankhwalawa amatsutsana ndi olaquindox, kitasamycin, virginiamycin, ndi Enramycin.
Monga chowonjezera cha chakudya, chimagwiritsidwa ntchito makamaka kulimbikitsa kukula kwa ziweto ndi nkhuku, kuteteza kutsekula m'mimba kwa ng'ombe ndi nkhuku ndi magazi chifukwa cha treponema.Zinc ya bacitracin imalowetsedwa m'kati mwake, ndipo zambiri zimachotsedwa ndi ndowe mkati mwa masiku a 2, kotero sikophweka kukhalabe mu ziweto ndi nkhuku;Kaŵirikaŵiri mabakiteriya sayamba kukana bacitracin, ndipo salimbana ndi maantibayotiki ena, Ndipo amagwira ntchito limodzi ndi penicillin, streptomycin, neomycin, aureomycin, polymyxin, ndi zina zotero.Mankhwalawa amatsutsana ndi olaquindox, kitasamycin, virginiamycin, ndi Enramycin.
Bacitracin Zinc ndi mankhwala a polypeptide, omwe ali ndi bactericidal pa mabakiteriya a gram-positive.Limagwirira ake makamaka ziletsa bakiteriya khoma kaphatikizidwe mabakiteriya, ndipo akhoza kuphatikiza ndi selo nembanemba wa tcheru mabakiteriya, kuwononga umphumphu wa selo nembanemba, ndi chifukwa The outflow wa zinthu zofunika mu selo.Kuletsa bwino mabakiteriya a gram-positive ndi mabakiteriya ena a gram-negative;kuchuluka kwa mabakiteriya kukana bacitracin zinki kumachedwa, ndipo palibe kutsutsana ndi maantibayotiki ena.Mankhwala a polypeptide amalepheretsa dephosphorylation ya lipid pyrophosphate, motero amalepheretsa kaphatikizidwe ka makoma a cell cell.
