Baloxavir Marboxil CAS 1985606-14-1 API Factory High Quality

Kufotokozera Kwachidule:

Dzina la mankhwala: Baloxavir Marboxil

CAS: 1985606-14-1

Maonekedwe: Ufa Woyera mpaka Woyera

Chiwerengero: 98.0% ~ 102.0%

Pochiza Fuluwenza A ndi Influenza B Infections

Lumikizanani ndi Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Kufotokozera:

Shanghai Ruifu Chemical Co., Ltd. ndiwopanga wamkulu wa Baloxavir Marboxil (CAS: 1985606-14-1) wokhala ndipamwamba kwambiri.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Chemical Properties:

Dzina la Chemical	Baloxavir Marboxil
Mawu ofanana ndi mawu	BXM;S-033188
Nambala ya CAS	1985606-14-1
Stock Status	Mu Stock, Kupanga Kufikira Mazana a Kilogram
Molecular Formula	Chithunzi cha C27H23F2N3O7S
Kulemera kwa Maselo	571.55
Kuchulukana	1.57±0.10 g/cm3
Kusungunuka	Zosungunuka mu DMSO
Kusungirako Nthawi Yaitali	Sungani Nthawi Yaitali pa -20 ℃
COA & MSDS	Likupezeka
Chiyambi	Shanghai, China
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Woyera mpaka Woyera
Chizindikiritso	IR Spectrum imagwirizana ndi muyezo Nthawi yosungirayo imagwirizana ndi muyezo
Mkati mwa Madzi (wolemba KF)	≤1.0%
Kutaya pa Kuyanika	≤1.0%
Zotsalira pa Ignition	≤0.50%
Zitsulo Zolemera	≤20ppm
Zogwirizana nazo
Kusayera Kwambiri Payekha	≤0.50%
Zonse Zonyansa	≤1.0%
Tinthu Kukula	D90 Pass 150um
Chiral Purity	≥99.0%
Chiyero	≥99.0%
Kuyesa	98.0% ~ 102.0%
Zosungunulira Zotsalira	Tsatirani Zofunikira za ICH
Manyamulidwe	Kutumiza Ndi Ice Pack
Test Standard	Enterprise Standard
Kugwiritsa ntchito	API, pochiza Influenza A ndi Influenza B Infections

Phukusi & Kusungira:

Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.

Ubwino:

FAQ:

1985606-14-1 - Ntchito:

Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) ndi mankhwala oletsa ma virus opangidwa ndi Shionogi Co., kampani yaku Japan yopanga mankhwala ndi Roche pochiza matenda a fuluwenza A ndi fuluwenza B.Mankhwalawa adavomerezedwa kuti agwiritsidwe ntchito ku Japan mu February 2018 ndikuvomerezedwa ndi FDA pa Okutobala 24, 2018 kuti azichiza chimfine chovuta kwambiri kwa odwala azaka 12 kapena kuposerapo omwe akhala ndizizindikiro kwa maola osapitilira 48 Label.Baloxavir marboxil, cap-endonuclease inhibitor, ili ndi njira yapadera yochitirapo kanthu poyerekeza ndi gulu lomwe lilipo pano la neuraminidase inhibitor lomwe limagwiritsidwa ntchito pochiza matenda a chimfine.Baloxavir Marboxil ndi mankhwala atsopano oletsa chimfine okhala ndi njira yatsopano yochitira.Baloxavir Marboxil ndi mankhwala a Baloxavir Acid (S-033447) omwe amaletsa mwamphamvu komanso mosankha endonuclease yomwe imadalira kapu mkati mwa polymerase PA subunit ya ma virus a fuluwenza A ndi B, zomwe zimalepheretsa kusindikiza ndi kubwereza kwa RNA.Baloxavir adafufuzidwanso kuti atha kuchiza COVID-19 koma palibe phindu lotsimikizika lomwe lawonedwa.

1985606-14-1 - Njira Zochita:

Baloxavir Marboxil ndi mankhwala ochizira chimfine, makamaka, inhibitor ya enzyme yomwe imayang'ana ntchito ya endonuclease yodalira kachilombo ka fuluwenza, imodzi mwazochita za virus polymerase complex.Makamaka, imalepheretsa njira yomwe imadziwika kuti kuthyola kapu, komwe kachilomboka kamatengera zoyambira zazifupi, zojambulidwa kuchokera ku cell cell RNA transcripts, zomwe zimagwiritsa ntchito popanga ma polymerase-catalyzed synthesis ya ma virus omwe amafunikira mRNAs.Gulu la polymerase limamangiriza ma pre-mRNA omwe amakhalapo pazipewa zawo za 5', ndiye kuti ntchito ya polymerase endonuclease imapangitsa kung'ambika kwake "pambuyo pa 10-13 nucleotides".Momwemonso, makina ake ndi osiyana ndi neuraminidase inhibitors monga Oseltamivir ndi Zanamivir.

1985606-14-1 - Pharmacokinetics:

Baloxavir Marboxil ndi choletsa chosankha cha fuluwenza cap-dependent endonuclease chomwe chimalepheretsa ntchito ya polymerase motero kachilombo ka fuluwenza mRNA kubwerezabwereza 5, 3. Yawonetsa ntchito zochizira matenda a fuluwenza A ndi B, kuphatikiza mitundu yolimbana ndi ma antivayirasi apano. imalepheretsa puloteni yofunikira pakugawanika kwa ma virus, motero imachiza matenda a chimfine mwachangu 5, Lembetsani ndikuchepetsa zizindikiro zokhudzana ndi matenda.Mlingo umodzi wa mankhwalawa unasonyezedwa kuti ndi wapamwamba kuposa placebo pochotsa zizindikiro za chimfine komanso kuposa oseltamivir ndi placebo mankhwala mu zotsatira za virologic (zodziwika ndi kuchepa kwa ma virus).

1985606-14-1 - Zizindikiro:

Baroxavir ndi yoyenera kwa odwala ≥ azaka 12 omwe ali ndi chimfine chovuta kwambiri komanso omwe zizindikiro zawo sizidutsa maola 48.Chisamaliro chiyenera kuperekedwa ku zoperewera za mankhwala: kachilombo ka fuluwenza kamasintha pakapita nthawi, ndipo pali zinthu monga mtundu wa kachilombo ka HIV ndi subtype.Kamodzi kukana mankhwala kwa kachilomboka ndi kusintha kwa kachilombo ka HIV, mphamvu yamankhwala ya antiviral imatha kufooka.Posankha kutenga basalovir dipivoxil, zomwe zilipo zokhudza tilinazo m`deralo mliri HIV kupsyinjika kwa mankhwala ayenera kuganiziridwa.

1985606-14-1 - Ntchito:

Baloxavir Marboxil ndi mankhwala a chimfine, antiviral, omwe amatengedwa ngati piritsi limodzi, pakamwa, ndi anthu azaka 12 kapena kupitilira apo, omwe awonetsa zizindikiro za matendawa kwa maola osapitilira 48. Kugwira ntchito kwa baloxavir marboxil yoperekedwa pambuyo pa maola 48 sanayesedwe.

1985606-14-1 - Zotsutsana:

Baloxavir Marboxil sayenera kuperekedwa limodzi ndi zinthu zamkaka, zakumwa zokhala ndi calcium, kapena mankhwala ofewetsa thukuta, maantacid, kapena mankhwala amkamwa okhala ndi calcium, chitsulo, magnesium, selenium, aluminiyamu kapena zinki.

1985606-14-1 - Zotsatira zake:

Zotsatira zoyipa zomwe zimachitika pambuyo popereka mlingo umodzi wa baloxavir marboxil ndi monga kutsekula m'mimba, bronchitis, chimfine, mutu, ndi nseru.Zochitika zoyipa zidanenedwa mu 21% ya anthu omwe adalandira baloxavir, 25% mwa omwe amalandila placebo, ndi 25% ya Oseltamivir.

1985606-14-1 - Kukonzekera:

Patent yaku Japan JP6212678 idanenanso njira yophatikizira ya Baloxavir Marboxil.3, 4-difluorobenzoic acid idagwiritsidwa ntchito ngati zopangira kuti zigwirizane ndi DMF pansi pa zochita za LDA kupeza 2-formyl-3, 4-difluorobenzoic acid.Kenako imapanga thioacetal ndi thiophenol, kenako imachepetsedwa ndikusiyanitsidwa ndi borane kuti ipeze 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11 (6H) -imodzi, ndipo pamapeto pake chidutswa chachikulu cha thiazepine 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-mowa amapezedwa pansi pa kuchepetsa sodium borohydride.Kugwiritsa ntchito 3-(benzyloxy) -4-oxo-4H-pyran-2-carboxylic acid kuti achite ndi tert-butyl formate pambuyo pa esterification kuti apeze 3-(benzyloxy) -1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, ndiyeno ndi 2-(2, 2-dimethoxyethoxy) ethylamine amakumana ndi urethane kusinthana anachita, ndiyeno cyclizes pansi zochita za methanesulfonic asidi kupeza 7-(benzyloxy) -3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f] [1,2,4] triazine -6, 8-dione hemihydrate, ndiye ndi condensed ndi (R) -tetrahydrofuran -2-formic acid, ndiye crystallized ndi kuthetsedwa, ndiyeno chiral wothandiza gulu amachotsedwa kupeza chinsinsi chiral kholo mphete molekyulu (R) -7-(benzyloxy) -3,4,12, 12a-tetrahydro-1H- [1,4] oxazino [3,4-c] pyrido [2,1-f] [1,4] Triazine-6, 8-dione.Ndiye mafungulo a mphete ya kholo amagwiritsidwa ntchito kusinthanitsa ndi n-hexanol pansi pa zochita za Grignard reagent, ndiyeno ndi chidutswa chachikulu cha thiazepine 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-alcohol docking. , ndipo potsiriza kutulutsa ndi kusungunuka ndi methyl chloroformate kuti mupeze mankhwala omaliza a Baloxavir Marboxil.