Betamethasone CAS 378-44-9 Purity 97.0%~103.0% API Factory High Purity

Betamethasone
C22 H29FO5 392.46
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16)-.
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
Betamethasone ili ndi zosachepera 97.0 peresenti komanso zosaposa 103.0 peresenti ya C22H29FO5, yowerengedwa pa zouma.
Kupaka ndi kusunga-Sungani zotengera zothina.Sungani pakati pa 2 ℃ ndi 30 ℃.
Miyezo yolozera ya USP <11>-
USP Betamethasone RS
Chizindikiritso-
A: Infuraredi mayamwidwe <197M>.
B: Thin-Layer Chromatographic Identification Test <201>-
Njira yothetsera mayeso-Konzani njira ya Betamethasone mu mowa wopanda madzi wokhala ndi 0.5 mg pa ml.
Kupanga zosungunulira dongosolo: chisakanizo cha chloroform ndi diethylamine (2: 1).
Njira-Chitani monga momwe tafotokozera m'mutuwu, kupatulapo kupeza mawanga popopera pang'ono ndi mchere wa sulfuric acid (1 mu 2) ndi kutentha pa mbale yotentha kapena pansi pa nyali mpaka mawanga atawonekera.
Kuzungulira kwachindunji <781S>: pakati pa +118 ndi +126, kuwerengeredwa pazowuma.
Njira yothetsera mayeso: 5 mg pa mL, mu methanol.
Kutaya pakuyanika 731-Yanikani pa 105 kwa maola atatu: imataya osapitirira 1.0% ya kulemera kwake.
Zotsalira pakuyatsa 281: osapitirira 0.2%, platinamu crucible ikugwiritsidwa ntchito.
Zodetsedwa wamba 466-
Njira yothetsera mayeso: methanol.
Njira yothetsera: methanol.
Kuchuluka kwa ntchito: 10 µL.
Eluant: chisakanizo cha toluene, acetone, methyl ethyl ketone, ndi formic acid (55:20:20:5), m'chipinda chopanda malire.
Kuwona: 5.
Kuyesa-
Mobile phase-Konzani madzi osefedwa ndi degassed madzi ndi acetonitrile (63:37).Sinthani ngati kuli kofunikira (onani Kukwanira Kwadongosolo pa Chromatography 621).
Internal standard solution-Konzani yankho la propylparaben mu mowa wokhala ndi ndende yodziwika pafupifupi 0.25 mg pa ml.
Kukonzekera kokhazikika-Sungani mlingo woyezera bwino wa USP Betamethasone RS mu mowa kuti mupeze yankho lodziwika bwino la pafupifupi 0.2 mg pa mL.Tumizani 10.0 mL ya yankho ili mu vial yoyenera, ndikuwonjezera 10.0 mL ya Internal standard solution, kuti mupeze kukonzekera Kwanthawi zonse kodziwika bwino kwa pafupifupi 0.1 mg ya betamethasone ndi pafupifupi 0.125 mg ya propylparaben pa ml.
Kukonzekera koyesa-Kugwiritsa ntchito pafupifupi 80 mg ya Betamethasone, yoyezedwa molondola, konzekerani monga momwe mwalangizidwira kukonzekera Standard.
Chromatographic system (onani Chromatography 621) - Chromatograph yamadzimadzi imakhala ndi chowunikira cha 240-nm ndi ndime ya 4.6-mm × 25-cm yomwe ili ndi zonyamula L1.Kuthamanga kwa madzi ndi pafupifupi 1.0 mL pamphindi.Chromatograph the Standard kukonzekera, ndikujambulitsa mayankho apamwamba monga momwe adayankhidwira Ndondomeko: nthawi yosungirako ndi pafupifupi 1.0 ya betamethasone ndi 1.4 ya propylparaben;kusamvana, R, pakati pa betamethasone ndi propylparaben sikuchepera 3.0;ndipo kupatuka kofanana kwa jakisoni wobwereza sikudutsa 2.0%.
Kachitidwe-Papatula jekeseni ma voliyumu ofanana (pafupifupi 10 µL) a Kukonzekera Kwanthawi zonse ndi kukonzekera kwa Assay mu chromatograph, lembani ma chromatogram, ndikuyesa mayankho a nsonga zazikulu.Werengani kuchuluka, mu mg, wa C22H29FO5 mu gawo la Betamethasone yotengedwa ndi formula:
800C(RU / RS)
momwe C ndi ndende, mu mg pa mL, wa USP Betamethasone RS mu Standard kukonzekera;ndi RU ndi RS ndi nsonga za kutalika kwa chiŵerengero cha betamethasone pachimake ndi nsonga ya mkati yomwe imapezeka kuchokera ku Kukonzekera kwa Assay ndi kukonzekera Standard, motsatira.