Bortezomib CAS 179324-69-7 Purity ≥99.0% (HPLC) API Factory High Purity
Perekani Othandizira a Bortezomib Okhala ndi Kuyera Kwambiri
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Bortezomib CAS 179324-69-7
| Dzina la Chemical | Bortezomib |
| Mawu ofanana ndi mawu | Velcade, MG-341, PS-341 |
| Nambala ya CAS | 179324-69-7 |
| Nambala ya CAT | RF-API65 |
| Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
| Molecular Formula | Chithunzi cha C19H25BN4O4 |
| Kulemera kwa Maselo | 384.24 |
| Melting Point | 122.0 ~ 124.0 ℃ |
| Kuchulukana | 1.214 |
| Refractive Index | 1.564 |
| Kusungunuka | Kusungunuka mu Chloroform, DMSO, Ethanol ndi Methanol |
| Kukhazikika | Hygroscopic ndi Chinyontho Chosamva |
| Mkhalidwe Wotumiza | Kutumizidwa Pansi pa Kutentha Kozungulira |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera kapena Woyera |
| Kuyera / Kusanthula Njira | ≥99.0% (HPLC) |
| Kutaya pa Kuyanika | ≤0.50% |
| Zotsalira pa Ignition | ≤0.20% |
| Kuzungulira kwa Optical | -41.0° ~ -46.0° |
| Chitsulo Cholemera | ≤20ppm |
| Acidity | 4.0-7.0 |
| Isomer | ≤0.50% |
| Chidetso Chimodzi | ≤0.50% |
| Zonse Zonyansa | ≤1.0% |
| Zosungunulira Zotsalira | |
| Methanol | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl Acetate | ≤0.50% |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni Drum, 25kg/ng'oma, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Shanghai Ruifu Chemical Co., Ltd. ndi amene amapanga ndi kugulitsa Bortezomib (CAS: 179324-69-7) ndi apamwamba, API.
Bortezomib, wogulitsidwa pansi pa dzina la Velcade pakati pa ena, ndi mankhwala oletsa khansa omwe amagwiritsidwa ntchito pochiza ma myeloma angapo ndi mantle cell lymphoma.Bortezomib inavomerezedwa kuti igwiritsidwe ntchito pachipatala ku United States ku 2003 ndi ku European Union ku 2004. Ili pa Mndandanda wa Mankhwala Ofunika Kwambiri a World Health Organization.Bortezomib ndiye woyamba proteasome inhibitor kuvomerezedwa b US FDA kwa angapo myeloma, khansa ya magazi.Reversible inhibitor ya 26S proteasome-tinthu tambirimbiri tomwe timaoneka ngati mbiya topezeka mu nyukiliyasi ndi cytosol ya maselo onse a eukaryotic.Bortezomib ndi chosankha komanso cholimba cha 26S proteasome inhibitor, chomwe ndi boronic acid dipeptide derivative.Kafukufuku wa maselo a khansa ya pancreatic akuwonetsa Bortezomib kuletsa PKR-monga endoplasmic reticulum (ER) kinase ndikuwonjezera kupsinjika kwa ER, zomwe zimatsogolera ku apoptosis.
