Brigatinib CAS 1197953-54-0 Chiyero>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga Brigatinib (AP-26113) (CAS: 1197953-54-0) yokhala ndi mawonekedwe apamwamba.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Brigatinib,Please contact: alvin@ruifuchem.com
Dzina la Chemical | Brigatinib |
Mawu ofanana ndi mawu | AP26113;AP-26113;5-Chloro-N4-[2-(Dimethylphosphinyl) phenyl]-N2-[2-Methoxy-4-[4-(4-Methyl-1-Piperazinyl)-1-Piperidinyl]phenyl]-2,4-Pyrimidinediamine |
Stock Status | Mu Stock, Commercial Production |
Nambala ya CAS | 1197953-54-0 |
Molecular Formula | Mtengo wa C29H39ClN7O2P |
Kulemera kwa Maselo | 584.09 g/mol |
Melting Point | > 203 ℃ (Dec.) |
Kuchulukana | 1.31±0.10 g/cm3 |
COA & MSDS | Likupezeka |
Chiyambi | Shanghai, China |
Mtundu | Ruifu Chemical |
Zinthu | Zofotokozera | Zotsatira |
Maonekedwe | Ufa Woyera mpaka Woyera | Zimagwirizana |
Kuyera / Kusanthula Njira | >99.0% (HPLC) | 99.26% |
Max.Chidetso Chimodzi | <1.00% | 0.25% |
Kutaya pa Kuyanika | <1.00% | 0.27% |
Infrared Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
1H NMR Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa |
Phukusi:Botolo la Fluorinated, thumba la Aluminiyamu zojambulazo, 25kg / Cardboard Drum, kapena malinga ndi zomwe kasitomala amafuna.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndipo sungani m'nyumba yozizira, yowuma komanso yolowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Brigatinib (AP-26113) (CAS: 1197953-54-0) ndi kafukufuku wang'onoang'ono wokhudzana ndi khansa yomwe imapangidwa ndi ARIAD Pharmaceuticals, Inc. Brigatinib ndi mankhwala omwe amagwiritsidwa ntchito pochiza khansa yomwe imachepetsa epidermal growth factor receptor (EGFR) ndi Anaplastic lymphoma kinase (ALK).Brigatinib ndi agonist wosankha motsutsana ndi mitundu yosiyanasiyana ya EGFR mosiyana ndi mitundu yosinthika yakuthengo.Mankhwalawa akuwonetsanso kusankhika motsutsana ndi jini ya ALK-EML4 fusion, yomwe ndi gawo lofunikira pakusintha kwaparenchyma yam'mapapo.Brigatinib amaperekedwa kwa odwala omwe ali ndi majini osadziwika bwino komanso pamene khansara yosakhala yaying'ono ya m'mapapo (NSCLC) siimayankha kuwongolera ndi mankhwala ena.Brigatinib imatchulidwa ngati kinase inhibitor, yomwe njira yake yochitirapo kanthu imaphatikizapo kupondereza zochita za mapuloteni osadziwika bwino omwe amathandizira kuchulukitsa kwa maselo a khansa.
Brigatinib (CAS: 1197953-54-0) amaperekedwa kwa odwala omwe ali ndi mitundu yeniyeni ya NSCLC yomwe yafalikira kumadera osiyanasiyana a thupi mwa anthu omwe akhala akuchiritsidwa kale ndi mankhwala ena a khansa monga Crizotinib, ndipo chikhalidwe chawo chikuipiraipira. kapena amaonetsa zizindikiro zochepa za kusintha.Imafufuzidwa makamaka chifukwa cha chithandizo chake pa khansa yosakhala yaying'ono ya m'mapapo (NSCLC) pomwe ALK imayatsidwa ndipo kusintha kwa EGFP kumachitika pafupipafupi.
Brigatinib (AP-26113) (CAS: 1197953-54-0) ndi inhibitor ya m'badwo watsopano wa tyrosine kinase, yomwe ikuwonetsa mphamvu kwambiri mu ALK + metastatic NSCLC.Pa Ogasiti 30, 2016, United States FDA idapereka bugtinib ngati chithandizo chothandizira komanso mankhwala osowa a ALK+NSCLC mwa odwala omwe apanga kapena sangathe kulekerera Crizotinib, chithandizo cham'badwo woyamba wa ALK+NSCLC.Yang'anirani kuwunikiranso kwazomwe mukulembera ndikulola kuti zofunsira zitumizidwe mosalekeza.A FDA adavomereza Bugtinib pa Epulo 28, 2017, pansi pa dzina la malonda Alunbrigtm.