Carvedilol CAS 72956-09-03 Chiyero>99.0% (HPLC)

Kufotokozera Kwachidule:

Dzina la mankhwala: Carvedilol

CAS: 72956-09-03

Kuyera: > 99.0% (HPLC)

Maonekedwe: White Crystalline Ufa

Lumikizanani ndi Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Kufotokozera:

Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga Carvedilol (CAS: 72956-09-03) yokhala ndi mawonekedwe apamwamba.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Carvedilol,Please contact: alvin@ruifuchem.com

Ogwirizana Apakati:

Zogwirizana ndi Carvedilol

N-(2-(2-Methoxyphenoxy)ethyl) benzylamine Hydrochloride	CAS: 3246-03-5
2-(2-Methoxyphenoxy) ethylamine Hydrochloride Hydrate	CAS 64464-07-9
2-(2-Methoxyphenoxy)ethylamine	Chithunzi cha CAS 1836-62-0
4-(2,3-Epoxypropoxy)carbazole	CAS 51997-51-4
4-Hydroxycarbazole	CAS 52602-39-8
1,3-Cyclohexanedione	CAS 504-02-9
Carvedilol	CAS 72956-09-03
Carvedilol Phosphate Hemihydrate	CAS 610309-89-2

Chemical Properties:

Dzina la Chemical	Carvedilol
Mawu ofanana ndi mawu	1-(9H-Carbazol-4-yloxy) -3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Wojambula;Cadilan;Carca;Carivas;Carloc;Carvas;Carvedilol;Carvediol;Coreg;Chithunzi cha 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;Mtengo wa BM-14190
Stock Status	Mu Stock, GMP Commerce
Nambala ya CAS	72956-09-3
Molecular Formula	Chithunzi cha C24H26N2O4
Kulemera kwa Maselo	406.48 g / mol
Melting Point	115.0 mpaka 119.0 ℃
Kuchulukana	1.250±0.06 g/cm3
Kusungunuka mu Madzi	Zosasungunuka m'madzi
Kusungunuka	Zosungunuka mu Methanol.Kusungunuka pang'ono mu Ethanol, Etha
Kusungirako Temp.	Malo Ozizira & Owuma (2~8℃)
COA & MSDS	Likupezeka
Mtundu	Ruifu Chemical

Zofotokozera:

Zinthu	Miyezo Yoyendera	Zotsatira
Maonekedwe	White Crystalline Powder	Zimagwirizana
Kutaya pa Kuyanika	≤0.50% (105 ℃ kwa 3 h)	0.25%
Zotsalira pa Ignition	≤0.10%	0.07%
Zogwirizana nazo
Zonse Zonyansa	≤0.50%	Zimagwirizana
Chidetso A	≤0.20%	Zimagwirizana
Chidetso C	≤0.02%	Zimagwirizana
Chidetso China Chilichonse Chamunthu	≤0.10%	Zimagwirizana
Zitsulo Zolemera (Pb)	≤10ppm	<10ppm
Kuyera / Kusanthula Njira	>99.0% (HPLC)	99.72%
Infrared Spectrum	Zimagwirizana ndi Kapangidwe	Zimagwirizana
Mapeto	Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zanenedwa

Phukusi/kusungirako/Manyamulidwe:

Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani mu chidebe chotsekedwa mwamphamvu.Sungani pamalo ozizira, owuma (2 ~ 8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.

Ubwino:

Mphamvu Zokwanira: Malo okwanira ndi akatswiri

Utumiki Waukatswiri: Ntchito imodzi yosiya kugula

Phukusi la OEM: Phukusi lamwambo ndi zolemba zilipo

Kutumiza Mwachangu: Ngati mkati mwa katundu, kuperekedwa kwamasiku atatu kumatsimikizika

Zinthu Zokhazikika: Khalani ndi katundu wokwanira

Thandizo laukadaulo: Yankho laukadaulo likupezeka

Custom Synthesis Service: Kuchokera pa magalamu mpaka ma kilos

Ubwino Wapamwamba: Anakhazikitsa dongosolo lathunthu lotsimikizira zaubwino

FAQ:

Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.

Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.

Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.

UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.

Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.

MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.

Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.

Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.

Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.

Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.

Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.

72956-09-3 - Zambiri Zachitetezo:

Nambala za Hazard N,Xn
Ndemanga Zowopsa 51/53-36/37/38-20/21/22
Ndemanga Zachitetezo 61-36-26
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS UA8670000
HazardClass IRRITANT
PackingGulu III
Zinthu Zowopsa 72956-09-3 (Deta Yazinthu Zowopsa)
Poizoni LD50 pakamwa pa galu:> 1gm/kg

72956-09-3 -Ntchito:

Carvedilol (CAS: 72956-09-03) ndi vasodilating beta-blocker yothandiza pochiza matenda oopsa komanso angina pectoris.Kuphatikiza pa kutsitsa kuthamanga kwa magazi, carvedilol imachepetsa kukana kwathunthu kwa mitsempha popanda reflex tachycardia yomwe imachitika ndi vasodilators.Amanenedwa kuti amalekerera bwino ndi kuwonongeka kwa aimpso.

Carvedilol idayambitsidwa koyamba ku Belgium mu 1985. Izi zitha kuletsa zolandilira alpha ndi beta, palibe zochitika zapakatikati, pamafashoni apamwamba ndi kutsutsa kwa calcium.Imakhala ndi mphamvu yotsekereza zolandilira beta, zomwe zimatha kukulitsa mitsempha yamagazi, kuchepetsa kukana kwa zotumphukira komanso kutsika kwa magazi, ndipo sizikhudza kwambiri kutulutsa kwamtima ndi kugunda kwa mtima.Clinical angagwiritsidwe ntchito chachikulu matenda oopsa ndi angina pectoris.

72956-09-3 - USP 35 Standard:

TANTHAUZO

Carvedilol ili ndi NLT 98.0% ndi NMT 102.0% ya C24H26N2O4, yowerengedwa pa maziko owuma.

CHIZINDIKIRO

• A. Infrared Absorption <197K>

• B. Nthawi yosungira pachimake chachikulu cha Sample solution ikufanana ndi ya Standard solution, monga momwe zapezedwa mu Assay.

ZOYESA

• Ndondomeko

Chosungira: 2.72 g/L wa monobasic potaziyamu phosphate.Sinthani ndi kuchepetsa phosphoric acid kukhala pH ya 2.0.

Gawo lam'manja: Acetonitrile ndi Buffer (31:69)

Njira yothetsera kuyenerera: 0.05 mg/mL iliyonse ya USP Carvedilol RS ndi USP Carvedilol Related Compound A RS in Mobile phase

Njira yothetsera: 0.04 mg/mL ya USP Carvedilol RS mu gawo la Mobile

Yankho lachitsanzo: 0.04 mg/mL ya Carvedilol mu gawo la Mobile

Chromatographic system

(Onani Chromatography <621>, Kukwanira Kwadongosolo.)

Njira: LC

Chowunikira: UV 240 nm

Mzere: 4.6-mm × 15-cm;5-µm kunyamula L7

Kutentha kwapakati: 55 ℃

Kuthamanga: 1 mL / min

Nthawi yothamanga: 60 min

Kukula kwa jakisoni: 10 µL

Kuyenerera kwadongosolo

Zitsanzo: Yankho lolingana ndi dongosolo

Zofunikira zoyenera

Kusamvana: NLT 4.0 pakati pa carvedilol ndi carvedilol yokhudzana ndi gulu A

Chovala chamchira: NMT 1.5 pachimake cha carvedilol

Kupatuka kofananira: NMT 2%

Kusanthula

Zitsanzo: Yankho lokhazikika ndi yankho lachitsanzo

Werengani kuchuluka kwa carvedilol (C24H26N2O4) mu gawo lachitsanzo chomwe chatengedwa:

Zotsatira = (rU/rS) × (CS/CU) × 100

rU =	Kuyankha kwakukulu kwa carvedilol kuchokera ku Sample solution
rS =	Kuyankha kwakukulu kwa carvedilol kuchokera ku Standard solution
CS=	kuchuluka kwa carvedilol mu Standard solution (mg/mL)
KU =	kuchuluka kwa Carvedilol mu Sample solution (mg/mL)

Zovomerezeka zovomerezeka: 98.0% -102.0% pa zouma

ZOCHITSA

• Zotsalira pakuyatsa <281>: NMT 0.1% kuchokera ku 1 g

• Zitsulo Zolemera, Njira II <231>: NMT 10 ppm

• Zowonongeka Zamoyo, Ndondomeko 1: [Zindikirani-Pamaziko a zonyansa zomwe zilipo, chitani Zowonongeka Zamoyo, Njira 1 kapena Zowonongeka Zamoyo, Njira 2. Zowonongeka Zamoyo, Ndondomeko 2 ikulimbikitsidwa pamene carvedilol yokhudzana ndi chigawo F ndi chodetsa chotheka.]

Gawo la Buffer ndi Mobile: Konzekerani monga mwauzira mu Assay.

Njira yothetsera kuyenerera: 0.05 mg/mL iliyonse ya USP Carvedilol RS ndi USP Carvedilol Related Compound C RS mu gawo la Mobile

Njira yothetsera: 1 µg/mL iliyonse ya USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, ndi USP Carvedilol Related Compound E RS, ndi 0.2 µg/mL ya USP Carvedilo Yogwirizana Compound C RS mu gawo la Mobile

Yankho lachitsanzo: 1 mg/mL ya Carvedilol mu gawo la Mobile

Chromatographic system

(Onani Chromatography <621>, Kukwanira Kwadongosolo.)

Njira: LC

Detector: Dual wavelength, UV 220 ndi 240 nm.Gwiritsani ntchito 220 nm powerengera carvedilol yogwirizana ndi E, ndikugwiritsa ntchito 240 nm kwa carvedilol ndi mankhwala ena onse okhudzana nawo.

Mzere: 4.6-mm × 15-cm;5-µm kunyamula L7

Kutentha kwapakati: 55 ℃

Kuthamanga: 1 mL / min

Kukula kwa jekeseni: 20µL

Kuyenerera kwadongosolo

Zitsanzo: Yankho lolingana ndi dongosolo

Zofunikira zoyenera

Kusamvana: NLT 17 pakati pa carvedilol ndi carvedilol zokhudzana ndi C

Kusanthula

Zitsanzo: Yankho lokhazikika ndi yankho lachitsanzo

Kuwerengera kuchuluka kwa mankhwala okhudzana ndi carvedilol A, carvedilol yokhudzana ndi gulu B, carvedilol yogwirizana ndi C, carvedilol yokhudzana ndi gulu D, carvedilol yogwirizana ndi E, ndi zonyansa zina zilizonse mu gawo la Carvedilol lomwe latengedwa:

Zotsatira = (rU/rS) × (CS/CU) × 100

rU	=	Kuyankha kwakukulu kwapawiri kofananirako kapena zodetsa zilizonse kuchokera ku yankho lachitsanzo
rS	=	Kuyankha kwakukulu kwapawiri kofananirako kuchokera ku Standard solution.Kuti muwerenge kuchuluka kwa zodetsa zilizonse za munthu aliyense gwiritsani ntchito kuyankha kwapamwamba kwa carvedilol.
CS	=	Kuchulukirachulukira kwapawiri kofananirako mu Standard solution (mg/mL).Kuti muwerenge kuchuluka kwa zonyansa zina zilizonse za CS, gwiritsani ntchito kuchuluka kwa USP Carvedilol RS.
CU	=	kuchuluka kwa Carvedilol mu Sample solution (mg/mL)

Zoyenera kulandira: Onani Table 1.

Table 1

Dzina	Nthawi Yachibale Yosunga	Zoyenera Kulandila, NMT (%)
Carvedilol yogwirizana ndi Ea	0.35	0.1
Carvedilol yogwirizana ndi Ab	0.52	0.1
Carvedilol bisalkylpyrocatechol zotumphukira (ngati zilipo)c	0.70	0.15
Carvedilol	1.0	-
Carvedilol yogwirizana ndi Cd	3.6	0.02
Carvedilol zokhudzana ndi mankhwala De	5.0	0.1
Carvedilol yogwirizana ndi Bf	8.5	0.1
Chidetso china chilichonse cha munthu	-	0.10
Zonyansa zonse	-	0.5g
2-(2-Methoxyphenoxy) ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Musanyalanyaze zodetsa zilizonse zosakwana 0.01%.

• Zidetso Zachilengedwe, Ndondomeko 2

Yankho A: Acetonitrile ndi trifluoroacetic acid (100:0.1)

Yankho B: Trifluoroacetic acid ndi madzi (0.1:100)

Diluent: Acetonitrile, trifluoroacetic acid, ndi madzi (22:0.1:78)

Gawo la mafoni: Onani Table 2

Table 2

Nthawi (mphindi)	Solution A (%)	Solution B (%)
0	22	78
20	22	78
33	38	62
45	38	62
55	55	45
65	55	45
68	22	78
80	22	78

Njira yothetsera kuyenerera: 1.0 mg/mL ya USP Carvedilol System Suitability Mixture RS mu Diluent

Yankho lachitsanzo: 1 mg/mL ya Carvedilol mu Diluent

Chromatographic system

(Onani Chromatography <621>, Kukwanira Kwadongosolo.)

Njira: LC

Chowunikira: UV 240 nm

Mzere: 4.6-mm x 15-cm;5-µm kunyamula L68

Kutentha kwapakati: 30 ℃

Kuthamanga: 1.4 mL / min

Kukula kwa jekeseni: 20µL

Kuyenerera kwadongosolo

Zitsanzo: Yankho lolingana ndi dongosolo

Zofunikira zoyenera

Kusamvana: NLT 1.8 pakati pa carvedilol ndi carvedilol yogwirizana ndi F

Kusanthula

Chitsanzo: Yankho lachitsanzo

Werengani kuchuluka kwa zodetsa zilizonse mu gawo la Carvedilol lomwe watengedwa:

Zotsatira = (rU/rT) × 100

rU	=	kuyankha kwakukulu pachidetso chilichonse muchitsanzo cha yankho
rT	=	chiwerengero cha mayankho onse pachimake mu Zitsanzo yankho

Zoyenera kulandira: Onani Gulu 3.

Table 3

Dzina	Achibale Kusunga Nthawi	Kuvomereza Zofuna, NMT (%)
Carvedilol yogwirizana ndi Aa	0.7	0.1
Carvedilol	1.0	-
Carvedilol yogwirizana ndi Fb	1.2	0.1c
N-Isopropylcarvedilold	1.6	0.1
Carvedilol yogwirizana ndi Ce	1.8	0.02
Carvedilol yogwirizana ndi Bf	2.1	0.1
Biscarbazoleg	3	0.1
Chidetso china chilichonse cha munthu	-	0.1
Zonyansa zonse	-	0.5
a 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1- (2- (2-Methoxyphenoxy) ethylamino) -3- (6,7,8,9-tetrahydro-5H-carbazol-4-yloxy) propan-2-ol. c Chidetsochi chimawerengedwa pogwiritsa ntchito njira yomwe ili pansi pa Zonyansa Zachilengedwe, Njira 3: Carvedilol Related Compound F. d 1-(H-Carbazol-4-yloxy) -3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino] -2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy) -2-propanol.

• Zowonongeka Zachilengedwe, Ndondomeko 3: Carvedilol Related Compound F (ngati ilipo)

Yankho A: Trifluoroacetic acid ndi madzi (0.5:100)

Yankho B: Methanol ndi trifluoroacetic acid (100:0.5)

Diluent: Madzi ndi acetonitrile (1:1)

Gawo lam'manja: Yankho A ndi Njira B (65:35)

Njira yothetsera kuyenerera: 1.5 mg/mL ya USP Carvedilol System Suitability Mixture RS mu Diluent

Yankho lachitsanzo: 1.5 mg/mL ya Carvedilol mu Diluent yokonzedwa motere.Ntchito za 1.9 mL wa Diluent pa mg wa Carvedilol, ndi sonicate mwachidule kuti atsogolere kuvunda.

Chromatographic system

(Onani Chromatography <621>, Kukwanira Kwadongosolo.)

Njira: LC

Chowunikira: UV 226 nm

Mzere: 4.6-mm × 30-mm;3-µm kunyamula L7

Kutentha kwapakati: 40 ℃

Kuthamanga: 2 mL / min

Kukula kwa jakisoni: 10 µL

Kuyenerera kwadongosolo

Zitsanzo: Yankho lolingana ndi dongosolo

Zofunikira zoyenera

Kusamvana: NLT 2.0 pakati pa carvedilol ndi carvedilol yogwirizana ndi F

Kusanthula

Chitsanzo: Yankho lachitsanzo

Werengani kuchuluka kwa carvedilol yogwirizana ndi F mu gawo la chitsanzo chomwe chatengedwa:

Zotsatira = (rU/rT) × (1/F) × 100

rU	=	Kuyankha kwapamwamba kwa carvedilol yogwirizana ndi F kuchokera ku Sample solution
rT	=	kuchuluka kwa mayankho apamwamba a carvedilol ndi carvedilol okhudzana ndi gulu F kuchokera ku Sample solution
F	=	chifukwa choyankhira, 1.1

Zoyenera kulandira: NMT 0.1%

MAYESO AKE

• Kutaya pakuyanika <731>: Yanikani chitsanzo pa 105℃ kwa maola atatu: imataya NMT 0.5% ya kulemera kwake.

ZOWONJEZERA ZOFUNIKA

• Kupaka ndi Kusunga: Isungeni m’zotengera zothina, ndipo sungani m’chipinda chozizira bwino.

• Kulemba zilembo: Ngati mayeso a Organic Impurities opangidwa ndi HPLC kupatula Njira 1 agwiritsidwa ntchito, ndiye kuti cholemberacho chikuwonetsa mayeso omwe nkhaniyo ikugwirizana nawo.

• USP Reference Standards <11>

USP Carvedilol RS

USP Carvedilol Related Compound A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74

USP Carvedilol Yogwirizana Compound B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74

USP Carvedilol Yogwirizana Compound C RS
1-(9H-Carbazol-4-yloxy) -3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60

USP Carvedilol Yogwirizana Compound D RS
4-(Oxiran-2-ylmethoxy) -9H-carbazole.
C15H13NO2 239.27

USP Carvedilol Related Compound E RS
2-(2-Methoxyphenoxy)ethyl amine.
C9H13NO2 167.21

USP Carvedilol System Suitability Mixture RS
Kusakaniza pafupifupi 0.1% carvedilol zokhudzana pawiri F (1- (2- (2-Methoxyphenoxy) ethylamino) -3- (2,3,4,9-tetrahydro-1H-carbazol-5-yloxy) propan-2-ol) mu matrix a mankhwala a carvedilol.