Carvedilol Phosphate Hemihydrate CAS 610309-89-2 Purity>99.0% (HPLC)

Carvedilol Phosphate Hemihydrate (CAS: 610309-89-2) ndi kusankha kutsekereza α1-receptor komanso osasankha β-receptor blocker, palibe intrinsic Sympathimetic yogwira mankhwala, bioavailability wa 10 ~ 47%, osakhudzidwa ndi chakudya, zotsatira za α1 -receptor ndi yotsika kwambiri kuposa β1-ndi β2-receptor, kuchuluka kwamphamvu kwa β1-ndi β2-receptor blockade ndi 1:10 ~ 1:100.Zotsatira za blockade ya β1-receptor ndi pafupifupi 1/2 ya labetalol, ndipo blockade yake ya α1 imakhala yofooka kuposa prazosin.Imatha kukulitsa mitsempha yamagazi, kuchepetsa kukana kwa mitsempha yotumphukira, kukulitsa mitsempha yapamtima ndi aimpso, komanso kuchepetsa kuthamanga kwa pulmonary wedge.Zili ndi chitetezo chodziwikiratu pa hypoxia ya myocardial ndi kuvulala kwa myocardial chifukwa cha infarction ya myocardial, yomwe ingakhale yokhudzana ndi kutsekereza β-receptor, yomwe ingachepetse kuchepa kwa myocardial glycogen ndi kuwonjezeka kwa pH, ndi kuchepetsa kukula kwa infarct.
Carvedilol Phosphate Hemihydrate amagwiritsidwa ntchito pochiza matenda oopsa kwambiri komanso ocheperako ndipo amatha kugwiritsidwa ntchito payekha kapena kuphatikiza mankhwala ena a antihypertensive (makamaka thiazide diuretics).Pakuti symptomatic aakulu congestive mtima kulephera.
Carvedilol Phosphate Hemihydrate ndi wosasankha β/α-1 receptor blocker.Carvedilol amaletsa lipid peroxidation ndi IC50 ya 5 μM.Carvedilol ndi mankhwala oletsa kuthamanga kwa magazi omwe amatha kuwerengera angina pectoris ndi kulephera kwamtima.