Risperidone CAS 106266-06-2 Mayeso 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiye wopanga wamkulu wa Risperidone (CAS: 106266-06-2) wokhala ndipamwamba kwambiri.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Risperidone,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Risperidone |
| Mawu ofanana ndi mawu | 3--[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-imodzi;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Tab |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 106266-06-2 |
| Molecular Formula | Chithunzi cha C23H27FN4O2 |
| Kulemera kwa Maselo | 410.49 g / mol |
| Melting Point | 170.0 mpaka 174.0 ℃ |
| Kuchulukana | 1.38±0.10 g/cm3 |
| Kalasi Yowopsa | 6.1;Poizoni |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Mtundu | Ruifu Chemical |
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | Ufa Woyera mpaka Woyera | Zimagwirizana |
| Chizindikiro A | Mayamwidwe a infrared | Zimagwirizana |
| Chizindikiro B | Nthawi Yosungira: Imafanana ndi Kalozera | Zimagwirizana |
| Kutaya pa Kuyanika | <0.50% | 0.12% |
| Zotsalira pa Ignition | <0.10% | 0.07% |
| Zitsulo Zolemera | <0.001% | <0.001% |
| Zogwirizana nazo | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Chidetso Chilichonse Chosadziwika | <0.10% | <0.10% |
| Zonse Zonyansa | <0.30% | <0.30% |
| Kuyesa | 98.0 ~ 102.0% (Yowerengedwa pa Maziko Ouma) | 100.52% |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi USP 35 Standard | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Risperidone
Chithunzi cha C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-imodzi, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 8,9-tetrahydro-2-methyl-.
3--[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-imodzi [106266-06-2].
» Risperidone lili osachepera 98,0 peresenti osati kuposa 102.0 peresenti ya C23H27FN4O2, masamu pa maziko zouma.
Kupaka ndi kusunga- Sungani m'mitsuko yotsekedwa bwino.Sungani kutentha.
Miyezo yolozera ya USP <11>-
USP Risperidone RS
3--[2--[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-imodzi 410.48 CAS-106266-06-2
USP Risperidone System Suitability Mixture RS
Muli risperidone ndi pafupifupi 0.2% mwa zotsatirazi:
Z-Oxime-3-[2--[4-[(Z)-(2,4-difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imodzi.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imodzi.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imodzi.
[Zindikirani-Kusakaniza kumeneku kuli ndi risperidone, Z-oxime, 9-hydroxyrisperidone, ndi 6-methylrisperidone.]
Chizindikiritso-
A: Infrared mayamwidwe <197K>.
B: Nthawi yosungira pachimake chachikulu mu chromatogram ya Kukonzekera kwa Assay ikufanana ndi yomwe ili mu chromatogram ya Kukonzekera kwa Standard, monga momwe zapezedwa mu Assay.
Kutaya pakuyanika <731> - Yanikani mu vacuum pa 80 kwa maola 4: imataya osapitirira 0,5% ya kulemera kwake.
Zotsalira pakuyatsa <281>: osapitirira 0.1%, kuyesa kwa 2.0-g kukugwiritsidwa ntchito.
Zitsulo zolemera, Njira II <231>: 0.001%.
Zogwirizana nazo-
Yankho la Buffer, Solution A, Solution B, Mobile phase, Diluent, System suitability solution, ndi Chromatographic system-Konzekerani monga momwe mukuyendera mu Assay.
Yankho lokhazikika-Gwiritsani ntchito Kukonzekera Kwanthawi zonse, kokonzedwa monga momwe adanenera mu Assay.
Njira yothetsera-Gwiritsani ntchito kukonzekera kwa Assay.
Njira-Bayikirani ma voliyumu ofanana (pafupifupi 10 µL) a njira Yoyezera ndi Mayeso mu chromatograph, ndikujambulitsa chromatogram.Dziwani zodetsedwa pogwiritsa ntchito nthawi zosungira zomwe zaperekedwa mu Gulu 1, ndikuyesa mayankho apamwamba.Kuwerengera kuchuluka kwa risperidone iliyonse zokhudzana pawiri mu gawo la Risperidone zotengedwa ndi chilinganizo:
100(CS /CU)(rU / rS)(1/F)
momwe CS ndi CU ndizokhazikika, mu mg pa mL, za risperidone mu Standard solution ndi Test solution motsatana;rU ndiye malo okwera pachidebe chilichonse chopezedwa kuchokera ku Mayeso;rS ndi malo apamwamba kwambiri a risperidone otengedwa ku Standard solution;ndi F ndiye gawo loyankhira pa zonyansa zilizonse zokhudzana ndi risperidone.Kuwonjezera pa kusapyola malire mu Table 1, osapitirira 0.10% ya zonyansa zosadziwika (gwiritsani ntchito F mtengo wa 1.0) ndipo osapitirira 0.30% ya zonyansa zonse zomwe zimapezeka.Musanyalanyaze nsonga zonyansa zomwe zili zosakwana 0.05%.
Table 1
Relative Compound Relative Retention Time (RRT) Relative Response Factor (F) Limit (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3- [2- [4-[(E)-) (2,4-Difluorophenyl) (hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-imodzi
2 3- [2- [4-[(Z))-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-imodzi
3 (9RS) -3--[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imodzi
4 3--[2--[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-imodzi
5 (6RS) -3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-imodzi
Kuyesa-
Sungunulani 15.4 g ya ammonium acetate mu 1 L yamadzi.Sinthani ndi 10% asidi acid kukhala pH ya 6.5, ndikusakaniza.
Yankho A-Sakanizani 100 mL ya Buffer solution ndi 150 ml ya methanol mu botolo la volumetric 1000-mL, ndi kusungunula ndi madzi mpaka kuchuluka kwake.
Yankho B- Sakanizani 100 mL ya Buffer solution ndi 850 ml ya methanol mu botolo la volumetric 1000-mL, ndi kusungunula ndi madzi mpaka kuchuluka kwake.
Mobile phase-Gwiritsani ntchito zosakanikirana zosakanikirana za Solution A ndi Solution B monga momwe zalembedwera pa Chromatographic system.Sinthani ngati kuli kofunikira (onani Kukwanira Kwadongosolo pa Chromatography 621).
Diluent-Sakanizani 100 mL ya Buffer solution ndi 900 ml ya madzi ndi 1000 ml ya methanol.
Njira yothetsera kuyenerera kwa dongosolo-Konzani yankho la 1 mg pa mL ya USP Risperidone System Suitability Mixture RS mu Diluent.
Standard kukonzekera-Sungani molondola kulemera kuchuluka kwa USP Risperidone RS mu Diluent, ndi kuchepetsa kuchuluka, ndi stepwise ngati n'koyenera, ndi Diluent kupeza njira kukhala odziwika ndende pafupifupi 1.0 mg wa pa mililita.
Kuyesa kukonzekera - Sungunulani molondola kulemera kuchuluka kwa Risperidone mu Diluent, ndi kuchepetsa quantitatively, ndi stepwise ngati n'koyenera, ndi Diluent kupeza yankho kukhala ndende ya 1.0 mg pa mililita.
Chromatographic system (onani Chromatography <621>)- Chromatograph yamadzimadzi imakhala ndi chowunikira cha 275-nm ndi ndime ya 4.6-mm × 10-cm yomwe ili ndi 3-µm yonyamula L1.Kuthamanga kwa madzi ndi pafupifupi 1.5 ml pa mphindi.Kutentha kwapakati kumasungidwa pa 35. Chromatograph imakonzedwa motere.
Nthawi (mphindi) Yankho A (%) Yankho B (%) Kuwunika
0–1 70 30 isocratic
1–20 70®5 30®95 mzere wopendekera
20–25 5 95 isokerasi
25–27 5®70 95®30 mzere wopendekera
27–35 70 30 kuyanjanitsansoBayikeni yankho loyenera la System.Lembani mayankho apamwamba monga momwe adalangizidwira Ndondomeko, ndipo zindikirani nsonga za Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, ndi risperidone pogwiritsa ntchito nthawi zosungirako (RRT) kuchokera ku Table 1;kusamvana, R, pakati pa Z-oxime ndi 9-hydroxyrisperidone si osachepera 2.8;chinthu chotsatira cha risperidone sichiposa 1.5;ndi kupatuka kwachibale kwa jakisoni wobwereza sikupitilira 2.0% pachimake cha risperidone.
Kachitidwe- Lowetsani padera ma voliyumu ofanana (pafupifupi 10 µL) a Kukonzekera Kwanthawi zonse ndi kukonzekera kwa Assay mu chromatograph, ndikuyesa mayankho a pachimake cha risperidone.Werengani kuchuluka, mu peresenti ya C23H27FN4O2, mu gawo la Risperidone lotengedwa ndi chilinganizo:
100(CS /CU)(rU / rS)
momwe CS ndi CU ndizokhazikika, mu mg pa mL, za risperidone mu Kukonzekera kwa Standard ndi kukonzekera kwa Assay, motsatira;ndi rU ndi rS ndiwo mayankho apamwamba omwe apezedwa kuchokera ku kukonzekera kwa Assay ndi kukonzekera kwa Standard, motsatana.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
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Zizindikiro Zowopsa R25 - Zowopsa ngati zitamezedwa
R23/24/25 - Poizoni pokoka mpweya, kukhudzana ndi khungu komanso kumeza.
R11 - Yoyaka Kwambiri
Kufotokozera Zachitetezo S28 - Mukakhudza khungu, sambani nthawi yomweyo ndi sopo wambiri.
S36 - Valani zovala zoyenera zodzitetezera.
S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.)
S36/37 - Valani zovala zoteteza ndi magolovesi oyenera.
S16 - Khalani kutali ndi magwero oyatsira.
Ma ID a UN 3249
WGK Germany 3
RTECS UV1164800
HS kodi 2934999099
Kalasi Yowopsa 6.1(a)
Packing Gulu II
Risperidone (CAS: 106266-06-2) imakhala ndi zotsatira zotsutsana ndi 5HT2 receptors ndi D2 receptors.Risperidone ntchito pachimake ndi aakulu schizophrenia.Antipsychotic mankhwala.Risperidone ntchito zochizira pachimake ndi aakulu schizophrenia ndi zina zosiyanasiyana psychotic boma zoonekeratu zizindikiro zabwino (monga kuyerekezera zinthu m`maganizo, zokopa, maganizo matenda, chidani, kukayikira) ndi zizindikiro zoipa kwambiri (monga kusalabadira, mphwayi maganizo ndi mphwayi anthu, ochepa. mawu).Komanso imatha kuchepetsa zizindikiro zomwe zimakhudzidwa ndi schizophrenia (monga: kukhumudwa, kudziimba mlandu, nkhawa).Odwala amene Risperidone ndi ogwira kwa pachimake mankhwala, mu yokonza gawo la mankhwala, ndi Risperidone akhoza kupitiriza kusewera ake matenda lapamwamba.Risperidone, motero, ali ndi chithandizo chamankhwala pazizindikiro zabwino ndi zoyipa za schizophrenia ndipo amatulutsa zotsatira zochepa kwambiri makamaka zizindikiro za extrapyramidal poyerekeza ndi zomwe zimagwiritsidwa ntchito poyera D2 antipsychotics.Ilinso ndi kuthekera kowongolera kusiya kumwa mowa komanso kuledzera kwa cocaine.
