2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Intermediate Purity>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiwopanga 2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) yokhala ndi mawonekedwe apamwamba, apakati a Perampanel (CAS: 380917-97-5).Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Perampanel intermediates, Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Mawu ofanana ndi mawu | 2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2-(1,3,2-Dioxaborinan-2-yl) benzonitrile |
| Nambala ya CAS | 172732-52-4 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C10H10BNO2 |
| Kulemera kwa Maselo | 187.01 |
| Melting Point | 46.0 ~ 51.0 ℃ (lit.) |
| Kuchulukana | 1.13±0.10 g/cm3 |
| Kusungunuka | Zosungunuka mu Methanol |
| Kukhazikika | Hygroscopic |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera mpaka Kuwala Wachikasu kupita ku Crystal |
| Kuyera / Kusanthula Njira | >99.0% (HPLC) |
| Kutaya pa Kuyanika | <0.50% |
| Zotsalira pa Ignition | <0.20% |
| Chidetso Chimodzi | <0.50% |
| Zonse Zonyansa | <1.00% |
| Zitsulo Zolemera (monga Pb) | <20ppm |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Wapakatikati wa Perampanel (CAS: 380917-97-5) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani m'mitsuko yosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi.
Zizindikiro Zowopsa Xi - Zokwiyitsa
Zizindikiro Zowopsa
R20/21/22 - Zowopsa pokoka mpweya, kukhudzana ndi khungu komanso kumeza.
R36/37/38 - Zokwiyitsa maso, kupuma komanso khungu.
Kufotokozera Zachitetezo
S26 - Mukakhudzana ndi maso, muzimutsuka nthawi yomweyo ndi madzi ambiri ndipo funsani malangizo achipatala.
S36/37/39 - Valani zovala zodzitchinjiriza zoyenera, magolovesi ndi chitetezo chamaso/nkhope.
Ma ID a UN 3439
WGK Germany 3
TSCA No
Hazard Note Irritant
2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) imagwiritsidwa ntchito popanga Perampanel (CAS: 380917-97-5), wotsutsana ndi AMPA receptor.Perampanel (yopatsidwa chilolezo mu 2012) ndi AED ya m'badwo wachitatu yomwe imadziwika ndi dzina laumwini la Fycompa® (Eisai, Hatfield) ku UK ndi Banzel® (Eisai, Hatfield) ku USA.Mu Okutobala 2012, a US FDA adavomereza perampanel kuti azitha kukomoka pang'ono kwa odwala khunyu omwe ali ndi zaka zosachepera 12.Perampanel ndiye woyamba AMPA receptor antagonist kulandira chivomerezo cha FDA ngati AED.AMPA glutamate receptors amapezeka makamaka pa postsynaptic neurons mu ubongo.Monga mdani wosankha, wosapikisana wa AMPA, parampanel imalepheretsa kutsegulidwa kwa njira ya ion ndikuchepetsa kufalikira kwa kuthekera kochitapo kanthu.Perampanel idavomerezedwa ndi European EMA ndi US FDA mu Julayi ndi Okutobala 2012 motsatana, imagwiritsidwa ntchito pochiza odwala omwe akudwala pang'ono azaka za 12 kapena popanda kukomoka kwachiwiri.Pa June 22, 2015, Eisai adalengeza kuti US FDA idavomereza kukulitsa kwa chizindikiro cha Pirenparanide hydrate (Fycompa) ngati chithandizo chothandizira kukomoka koyambirira kwa tonic-clonic kwa odwala khunyu azaka 12 ndi kupitilira apo.
