1-(3-Methoxypropyl)-4-Piperidinamine CAS 179474-79-4 Prucalopride Succinate Intermediate Purity>98.0% (GC)

Mankhwalawa ndi 1-(3-Methoxypropyl) -4-Piperidinamine.Muli C9H20N2O adzakhala osachepera 98.0%, owerengeka pa maziko anhydrous.
[Katundu: Izi zimakhala zopanda mtundu mpaka zamadzimadzi zachikasu.
Tengani madzi oyenerera a mankhwalawa, onjezerani zosungunulira (methanol), musungunule, muzindikire molingana ndi njira yodziwira madzi (Zowonjezera Ⅷ M, njira yoyamba A), gwiritsani ntchito madontho a mayeso a Fisher kuti muwone mpaka yankho likusintha kuchokera kuchikasu chowala. kufiira bulauni kusonyeza pomalizira pake, ndikuchita mayeso ena opanda kanthu.Werengani motsatira ndondomekoyi: madzi sayenera kupitirira 1.0%.
Chinyezi (%) = (AB) F/W×100%
Pomwe, A ndi kuchuluka kwamadzi a Fisher omwe amadyedwa ndi chinthu choyesera (ml);
B ndi kuchuluka kwa madzi oyesera a Fisher omwe amadyedwa ndi malo opanda kanthu, ml;
F ndi kulemera kwa njira yoyesera ya Fisher yofanana ndi madzi pa 1ml, mg;
W ndi kulemera kwa chinthu choyesera, mg
Chidetso chimodzi
Malinga ndi momwe zinthu ziliri komanso njira zomwe zili pansi pa [kutsimikiza kwa zomwe zili], chromatogram inalembedwa ndipo nthawi yosungira kuchokera pachimake chachikulu inali nthawi za 3.Ngati pali chidebe pachimake pamayeso oyeserera, chidetso chimodzi sichiyenera kupitilira 0.5% ndipo kuchuluka kwa zonyansa zonse sikudzapitilira 2.0% molingana ndi njira yosinthira malo.
[Kutsimikiza kwa Zomwe zili] Malinga ndi njira yotsalira ya zosungunulira (Zowonjezera Ⅷ P)
(6%) cyanopropyl phenyl - (94%) dimethylpolysiloxane (kapena polarity ofanana) monga chokhazikika madzi capillary column;
Njira yotenthetsera yotenthetsera ya capillary column headspace sampling system yokhala ndi gasi chromatographic idagwiritsidwa ntchito.Kutentha koyamba kunali 100 ℃ kwa 5min, ndipo kutentha kunakwezedwa pa 15 ℃ pa mphindi kufika 250 ℃ kwa 4min.Kutentha kolowera kunali 250 ℃, ndipo chowunikira chinali 280 ℃.Kuthamanga kunali 4ml / min.Chiŵerengero cha shunt ndi 8: 1.
Pafupifupi 0.6g ya mankhwalawa adatengedwa, kuyeza bwino, kuyikidwa mu botolo la 10ml, kusungunuka ndi methanol ndikuchepetsedwa mpaka sikelo, ngati njira yothetsera mayeso.Yankho lachitsanzo linabayidwa ndi 1μl kwa nthawi zosachepera ziwiri zotsatizana.Dera lapamwamba la nsonga yoti liyezedwe linadziwika.Chiyero chachikulu chapamwamba sichinali chochepera 98.0% molingana ndi njira yokhazikika yamalo okhazikika.