Gefitinib Intermediate CAS 184475-71-6 Purity>99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol (CAS: 184475-71-6) yokhala ndi mawonekedwe apamwamba, apakati a Gefitinib (CAS Chithunzi: 184475-35-2).Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, zochepa komanso zochulukirapo zomwe zilipo.Gulani Gefitinib zapakati,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 4-(3-Chloro-4-Fluorophenylamino)-7-Methoxyquinazolin-6-ol |
| Mawu ofanana ndi mawu | FAAH-MU-2;O-Desmorpholinopropyl Gefitinib;4-(3-Chloro-4-Fluoroanilino) -6-Hydroxy-7-Methoxyquinazoline;Kusayera kwa Gefitinib;Gefitinib Intermediate VII |
| Nambala ya CAS | 184475-71-6 |
| Stock Status | Zilipo |
| Molecular Formula | Chithunzi cha C15H11ClFN3O2 |
| Kulemera kwa Maselo | 319.72 |
| Melting Point | >260 ℃ (Dec.) |
| Kuchulukana | 1.489±0.06 g/cm3 |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Pafupifupi White mpaka Gray Ufa |
| Melting Point | >260.0 ℃ |
| Kutaya pa Kuyanika | <1.00% |
| Zogwirizana nazo | |
| Chidetso Chimodzi | <1.00% |
| Zonse Zonyansa | <1.00% |
| Kuyera / Kusanthula Njira | >99.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Pakati pa Gefitinib (CAS: 184475-35-2) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi.
4-(3-Chloro-4-Fluorophenylamino) -7-Methoxyquinazolin-6-ol (CAS: 184475-71-6) ndi yapakatikati ya Gefitinib (CAS: 184475-35-2), metabolite ya Gefitinib.Gefitinib ndi antineoplastic target therapy mankhwala omwe ali ndi chidziwitso chapamwamba kwambiri chomwe chinapangidwa ndi British pharmaceutical company AstraZeneca;ndi mankhwala oyamba omwe amagwiritsidwa ntchito pochiza khansa ya m'mapapo yomwe si yaing'ono.Epidermal growth factor (EGF) ndi mtundu wa polypeptide yokhala ndi mamolekyulu ochulukirapo a 6.45x103, ndipo imatha kumangika ndi epidermal growth factor receptors (EGFR) pa chandamale cha cell membrane kuti iyambitse zamoyo.EGFR ndi mtundu wa tyrosine kinase (TK) cholandirira chamtundu, kotero chikamangidwa ndi EGF, chidzalimbikitsa TK kutsegula mu cholandirira.Izi zidzapangitsa kuti zotsalira za tyrosine mu cholandirira zikhale autophosphorylate ndi kutumiza zizindikiro zogawanika mosalekeza mu selo, zomwe zimapangitsa kuti maselo azichulukana ndi kusiyanitsa.Gefitinib imatchinga njira yotumizira ma cell a cell EGFR kuteteza kukula kwa chotupa, metastasis, ndi kukula kwa mitsempha yamagazi, ndipo imatha kuyambitsa chotupa cell apoptosis.
