3-Chloro-4-(3-Fluorobenzyloxy)aniline CAS 202197-26-0 Lapatinib Intermediate Purity>98.0% (HPLC)

3-Chloro-4-(3-Fluorobenzyloxy)aniline (CAS: 202197-26-0) ndi yapakatikati mu kaphatikizidwe ka Lapatinib / Lapatinib Ditosylate Monohydrate.
Lapatinib ndi mankhwala omwe amalimbana ndi khansa ya m'mawere yopangidwa ndi British GlaxoSmithKline Co. Human ErbB receptors ali amtundu wa I tyrosine kinase (TK) receptor banja, kuphatikizapo ErbB1 (EGFR), ErbB2 (HER2), ErbB3 (HER3), ndi ErbB4 (HER4) .The ErbB-1 (EGFR) ndi ErbB-2 (HER-2) zolandilira nthawi zambiri mopambanitsa kapena kusinthidwa zina mwa odwala khansa.Human epidermal growth factor receptor 2 (ErbB-2, HER-2) amadziwika kuti ndi oncogene yamunthu yogwirizana kwambiri ndi khansa ya m'mawere.Mawonekedwe ake apamwamba mu khansa ya m'mawere nthawi zambiri amaneneratu za metastasis ya lymph node ndi kusiyana koyipa kwa chotupa, ndi kusazindikira bwino.HER-2 ndi amodzi mwa mamolekyu omwe amawathandizira pamankhwala okhudzana ndi khansa ya m'mawere.Lapatinib imatha kuchita nthawi imodzi pa Her-1 Her-2.Zotsatira zachilengedwe za njirayi zomwe zimalepheretsa kuchulukana ndi kukula kwa maselo a chotupa ndizokulirapo kuposa kungochita chandamale chimodzi.Kuphatikizika kwa Lapatinib ndi Capecitabine kumagwiritsidwa ntchito pochiza odwala omwe ali ndi khansa ya m'mawere yapamwamba kapena ya metastatic yokhala ndi epidermal receptor2 yamunthu, yomwe idathandizidwa kale ndi anthracyclines, paclitaxel, ndi trastuzumab.Mayesero azachipatala awonetsa kuti Lapatinib imathandiziranso bwino odwala khansa yamtundu wa HER2 omwe ali ndi Herceptin kukana.