Vardenafil Wapakatikati CAS 224789-21-3 Chiyero> 99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one. (CAS: 224789-21-3) yokhala ndi khalidwe lapamwamba, lapakati la Vardenafil.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one |
| Mawu ofanana ndi mawu | Vardenafil Dessulfonyl Chidetso;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-imodzi;Vardenafil Propyl Imidazotriazinone Kusayera;Vardenafil Related Compound 1 |
| Stock Status | Mu Stock, Mphamvu Yopanga Matani 2 pamwezi |
| Nambala ya CAS | 224789-21-3 |
| Molecular Formula | C17H20N4O2 |
| Kulemera kwa Maselo | 312.37 g / mol |
| Melting Point | 142.0 ~ 148.0 ℃ |
| Kuchulukana | 1.26±0.10 g/cm3 |
| Kusungirako Nthawi Yaitali | Malo Ozizira & Owuma (2~8℃) |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Mtundu | Ruifu Chemical |
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | Ufa Woyera-Woyera mpaka Wachikasu Wotuwa | Off-White Powder |
| Melting Point | 142.0 ~ 148.0 ℃ | 146.0 ~ 147.0 ℃ |
| Kutaya pa Kuyanika | <1.00% (102 ℃, 3h) | 0.23% |
| Zitsulo Zolemera (Pb) | ≤20ppm | <20ppm |
| Kuyera / Kusanthula Njira | >99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
| Kugwiritsa ntchito | Pakati pa Vardenafil / Vardenafil Hydrochloride | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala kwa dzuwa ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
1. Maonekedwe: Ikani chitsanzocho pa pepala loyera ndikuwona maonekedwe ake, oyera mpaka achikasu otumbululuka.
2. Kusanthula:
2.1 Kutsimikiza kwa Melting Point molingana ndi malamulo (Chinese Pharmacopoeia 2010 Edition II Zowonjezera ⅥC) Malo osungunuka ndi 142.0~148.0℃.
2.2 Kutaya pa Kuyanika: Kutsimikiza motsatira malamulo (Zowonjezera ⅧL, Gawo II, Kusindikiza kwa 2010 kwa Chinese Pharmacopoeia).Mwatsatanetsatane masekeli mlingo woyenera wa mankhwala, youma pa 102 ℃ kwa maola 3, kuwonda sadzakhala oposa 1.00%.
2.3 Zitsulo Zolemera: Kutsimikiza motsatira malamulo (People's Republic of China Pharmacopoeia Edition 2010, Gawo II Zowonjezera ⅧH) Kutsimikiza ndi njira yachiwiri.
Kusamalitsa kulemera kwa 1.0g ya mankhwala oyesera, kuyaka pang'onopang'ono mpaka mpweya wokwanira, ozizira, onjezerani 0.5-1.0ml sulfuric acid, ukhale wonyowa, kutentha kutentha pang'ono mpaka sulfuric acid itatha, onjezerani 0.5ml nitric acid, nthunzi youma, mpaka mpweya wa nitrogen oxide watha, wozizira, wotentha pa 500-600 ℃ kuti ukhale wa carbonized, ozizira, onjezerani 2ml hydrochloric acid, Mukatha kuyanika mumadzi osamba, onjezani madzi 15ml, kusiya yankho la ammonia mpaka lisakhale ndale ku chizindikiro cha phenolphthalein. yankho, onjezani 2ml acetate buffer (ph3.5), ndi kusungunula kutentha pang'ono, sunthirani ku chubu cha Nachner colorimetric, ndi kusungunula mu 25ml ndi madzi.Tengani reagent ina pokonzekera yankho la mayeso, ndikuwotchera mu mbale yadothi, onjezerani 2ml acetate buffer (PH3.5) ndi 15ml madzi kutentha pang'ono Mukatha kusungunuka, sunthani chubu cha Nath colorimetric, onjezerani njira yowonjezera yowonjezera, kenako tsitsani ndi madzi mpaka 25ml.Kuyesera kwa colorimetric kumachitika pakati pa mayeso oyesa ndi njira yokhazikika yopezera.Standard yankho kukonzekera molingana ndi (People's Republic of China Pharmacopoeia 2010 kope II Zowonjezera Ⅷ Heavy metal test method) njira yoyamba.Zitsulo zolemera siziyenera kupitirira magawo 20 pa miliyoni.
3. Chiyero: Malinga ndi mkulu ntchito madzi chromatography, anatsimikiza malinga ndi lamulo (Chinese Pharmacopoeia 2010 kope II Zakumapeto VD).
Matenda a Chromatographic:
Mzere: C18, 200mm×4.6mm, 5μm;
Gawo la mafoni: Phosphate buffer (kulemera 2.72g potassium dihydrogen phosphate, kuwonjezera madzi kuti asungunuke ndi kusungunula ku 1000ml, kusintha pH = 3.5) : acetonitrile: = 35:65;
Kutalika kwa mawonekedwe: 254nm;
Kuthamanga: 1.0ml / min.
Njira yodziwira: Tengani pafupifupi 30mg ya mankhwalawa, muyese molondola, muchepetse ndi gawo la mafoni kuti mutengere pafupifupi 0.3mg/ml, tengani 20μl mu chromatograph yamadzimadzi, lembani chromatogram.Malinga ndi dera normalization njira, chiyero ndi osachepera 99.0%.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) ndi yapakatikati ya Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Vardenafil ndi PDE5 inhibitor yatsopano yomwe inayambika kuti ithandizidwe pakamwa pa vuto lachimuna la erectile ndipo imakhala yofanana kwambiri ndi sildenafil (Viagra), yomwe inali yoyamba ya PDE5 inhibitor yomwe inayambitsidwa mu 1998 chifukwa cha izi.
Vardenafil anali wothandizira wachiwiri kuti agulitsidwe ndipo anali ndi mwayi woti nthawi yake yoyamba sinachepetsedwe ndi kumwa mankhwala pamimba yonse .Ndi nthawi 30 yamphamvu kwambiri ngati inhibitor ya PDE5 (kutanthauza IC50, 3.9 nM) kuposa sildenafil ndi nthawi 10 yamphamvu kuposa tadalafil, ndi kusankha kwakukulu (> 1,000 nthawi) kwa PDE5 yaumunthu kusiyana ndi PDE2, PDE3, ndi PDE4 yaumunthu ndi kusankha kwapakati (> 80 nthawi) kwa PDE1.PDE inhibitory selectivity komanso in vitro ndi in vivo potency ya PDE5 inhibitor vardenafil.Vardenafil makamaka inaletsa hydrolysis ya cGMP ndi PDE5, ndi IC50 ya 0.7 nM (sildenafil 6.6 nM).IC50 ya vardenafil ya PDE1 inali 180 nM, ya PDE6 11 nM, ndi PDE2, PDE3 ndi PDE4 kuposa 1,000 nM.
