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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
Ruifu Chemical ndi omwe amatsogolera Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) yokhala ndi mawonekedwe apamwamba, apakati a Apixaban (CAS: 503612-47-3).Ruifu atha kubweretsa padziko lonse lapansi, mtengo wampikisano, zochepa komanso zochulukirapo zomwe zilipo.Gulani Apixaban intermediates, E-mail: alvin@ruifuchem.com
| Dzina la Chemical | Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Mawu ofanana ndi mawu | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Apixaban Chidetso 3 |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 27143-07-3 |
| Molecular Formula | Chithunzi cha C11H13ClN2O3 |
| Kulemera kwa Maselo | 256.69 g / mol |
| Melting Point | 94 ℃ |
| Kuchulukana | 1.23 |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Gulu | Wapakatikati wa Apixaban (CAS: 503612-47-3) |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Wachikasu Wopepuka mpaka Wachikasu | Zimagwirizana |
| Kutaya pa Kuyanika | <0.50% | 0.23% |
| Kuyera / Kusanthula Njira | ≥99.0% (HPLC) | 99.3% |
| Infrared Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| 1 H NMR Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Mndandanda wa Zosungunulira Zogwiritsidwa Ntchito Popanga
| Ayi. | Dzina | CAS No. | Molecular Formula |
| 1 | Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Mowa wa Ethyl | CAS: 64-17-5 | C2H5OH |
5.3.1 Maonekedwe: Ayenera kukhala achikasu opepuka mpaka achikasu.Poyang'ana, ikani kuchuluka kwa zinthu zoyezera (popanda kuyeza) mu mbale yoyera ya kristalo pamalo oyera (monga pepala loyera) pansi pa kuwala kwachilengedwe.
5.3.2 Chizindikiritso: 1H-NMR ili ndi dongosolo lofanana ndi muyezo.10 ~ 15mg wa chitsanzo anali kuyezedwa mu chubu nyukiliya maginito, ndi 0.5mL wa deuterium DMSO anawonjezedwa kuti kwathunthu kupasuka chitsanzo, ndiyeno kuyesedwa ndi nyukiliya maginito resonance chida oposa 400MHz.
5.3.3 Kutaya pakuyanika : Yezerani chitsanzo cha 1.0g ndikuumitsa kwa 3h mu uvuni wowumitsa pa 85 ℃.Ntchito yeniyeni yowerengera kuwonda iyenera kuchitidwa molingana ndi zomwe SOP-AP-QC-002-01 ya Kutsimikiza Kuwumitsa Kuwonda.
5.3.4.1 Mikhalidwe ya Chromatographic:
Zoyeserera zoyeserera: 1) acetonitrile ya chromatography 2) madzi oyeretsedwa 3) phosphoric acid
Mzere: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Mobile gawo: A: Yesani molondola 1.0ml phosphoric acid ndi 1000ml madzi, fyuluta akupanga degassing.
B: Acetonitrile.
Ndondomeko ya gradient: tebulo ili pansipa
Nthawi yam'manja gawo A (%) Gawo B (%)
3 9010
10 2575
20 0100
25 0100
Chowunikira: 210nm
Kutentha kwapakati: 35 ℃
Kuthamanga: 1.0ml / min
Kukula kwachitsanzo: 5µl
5.3.4.2 Kukonzekera yankho:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Njira yopanda kanthu: Diluent iyenera kugwiritsidwa ntchito ngati yankho lopanda kanthu.
5.3.4.5 Njira yothetsera mayeso: Yezerani chinthu choyezera pafupifupi 12.5mg mu botolo la volumetric 25ml ndikusungunula ndi diluent mpaka sikelo.
5.3.4.6 Njira yogwiritsira ntchito: Pambuyo pa chiyambi cha chidacho chitakhazikika, jekeseni imodzi kapena iwiri ya yankho lopanda kanthu imatsogola, ndiyeno yankho la mankhwala oyesera likufufuzidwa.Chromatogram imasungidwa ndikuwunikidwa, chiwongola dzanja chopanda kanthu chimachotsedwa, ndipo chiyerekezo chachikulu kwambiri komanso zotsatira zachidetso chimodzi pa chromatogram yazomwe zimayesedwa zimajambulidwa ndi njira yosinthira madera.Pambuyo pakuwunika, chromatogram idasindikizidwa.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) amagwiritsidwa ntchito ngati wapakatikati pakupanga Apixaban (CAS: 503612-47-3).Apixaban ndi mtundu watsopano wa oral factor Xa inhibitor wopangidwa pamodzi ndi Bristol-Myers Squibb ndi Pfizer.Dzina lamalonda ndi Erroto.Ndi mtundu watsopano wa anticoagulant wapakamwa.Poletsa coagulation factor Xa, apixaban imatha kuletsa kupanga thrombin ndi thrombosis.Apixaban idapangidwa ndi Bristal-Myers squibb Company.Ili ndi bioavailability yabwino komanso kusankha kwakukulu.Zinalembedwa ku China mu 2013. Apixaban ndi otetezeka, kuthekera kwa kuyanjana kwa mankhwala ndi kochepa, ndipo pali njira zambiri zothetsera izo, zomwe zimayenera kugwiritsidwa ntchito m'magulu apadera omwe akudwala matenda a chiwindi kapena kuwonongeka kwa impso.
![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
