1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-one CAS 27387-31-1 Ondansetron HCl Dihydrate Intermediate Purity>99.0% (HPLC)

1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-imodzi (CAS: 27387-31-1) imagwiritsidwa ntchito ngati yapakatikati ya Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9).Kukula kwa kampani yaku United Kingdom Glaxo, 1990 ku France, msika waku United Kingdom.Mankhwalawa ndi osankhidwa kwambiri a serotonin (5-HT3) receptor antagonist, amatha kulepheretsa Nausea chifukwa cha chemotherapy ndi radiotherapy Masanzi, okhala ndi mphamvu zambiri komanso kusankha kwakukulu, amatha kulamulira matumbo aang'ono ndi ma CTZ omwe amayamba chifukwa cha kukondoweza kwa Vomit.Ndi oyenera zochizira Mseru Masanzi chifukwa cha chemotherapy ndi radiotherapy, komanso angagwiritsidwe ntchito kupewa ndi kuchiza Mseru kusanza chifukwa pambuyo opaleshoni.

Ondansetron, granisetron ndi dolasetron ndi mankhwala atatu a antiemetic omwe amagwiritsidwa ntchito kwambiri kuchipatala, ondansetron ndi amphamvu, osankha komanso osinthika 5-hydroxytryptamine (5-HT3) receptor blocker kwa Alpha 1, Alpha 2, beta 1, Beta 2 adrenergic receptors ndi histamine H1, H2 cholandilira chimakhala ndi zotsatira zochepa, ndipo sichikhala ndi zotsatira zotsutsana ndi H receptor, chapakati ndi zotumphukira za dopaminergic receptors, ndipo zimatha kuletsa Mseru ndi Masanzi chifukwa cha chemotherapy ndi radiotherapy.Poyerekeza ndi metoclopramide, Mphamvu ya antiemetic inali yamphamvu ndipo panalibe zochita za extrapyramidal.Cisplatin, cyclophosphamide, doxorubicin yoyambitsidwa ndi Vomit imatha kutulutsa mwachangu komanso mwamphamvu odana ndi nseru.Oyenera zochizira cytotoxic mankhwala chifukwa cha mankhwala amphamvu ndi poizoniyu mankhwala Mseru kusanza, komanso kupewa ndi kuchiza Mseru Masanzi chifukwa cha opaleshoni.ondansetron imagwira ntchito ngati malo osinthira pakati pa mitsempha ya visceral afferent m'matumbo am'mimba ndi Masanzi apakati pa msana, zomwe zimapangitsa kuti m'mimba ndi diaphragmatic ziziyenda.Mankhwala a Chemotherapy ndi mankhwala opatsirana pogwiritsa ntchito ma radiation angayambitse kutulutsidwa kwa 5-HT m'matumbo aang'ono, ndipo Vomit reflex imayamba chifukwa cha kukondoweza kwa mitsempha ya vagus kudzera mu cholandilira cha 5-HT3.Izi zimalepheretsa kuchitika kwa reflex iyi, ndikutsekereza Masanzi oyambitsidwa ndi zochitika zapakati.Limagwirira ntchito sanali kudziwika kwa Nausea Masanzi pambuyo opaleshoni.Ondansetron pamodzi ndi dexamethasone akhoza kumapangitsanso antiemetic kwenikweni.